دوره 13، شماره 3 - ( 7-1404 )
جلد 13 شماره 3 صفحات 30-25 |
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Heydarzadeh E, Azizbeigi K, Mohamadzadeh Salamat K. Aerobic exercise and resveratrol cooperatively modulate hippocampal mitochondrial mitophagy in Alzheimer’s disease rat models. Jorjani Biomed J 2025; 13 (3) :25-30
URL: http://goums.ac.ir/jorjanijournal/article-1-1066-fa.html
URL: http://goums.ac.ir/jorjanijournal/article-1-1066-fa.html
Aerobic exercise and resveratrol cooperatively modulate hippocampal mitochondrial mitophagy in Alzheimer’s disease rat models. فصلنامه علمی پژوهشی زیست پزشکی جرجانی. 1404; 13 (3) :25-30
URL: http://goums.ac.ir/jorjanijournal/article-1-1066-fa.html
چکیده: (3339 مشاهده)
Background: Mitochondrial proteostasis disruption in Alzheimer’s disease (AD) results in impaired mitochondrial autophagy (mitophagy). This study evaluated the effects of 8-week aerobic exercise training (T), resveratrol (RSV) supplementation, and their combination on mitophagy markers in an AD rat model.
Methods: In this experimental study, 35 male Wistar rats were divided into five groups: Control (NO), Alzheimer’s (AD), Alzheimer’s-Training (ADT), Alzheimer’s-Resveratrol (ADRSV), and Alzheimer’s-Training-Resveratrol (ADTRSV). RSV groups received 20 mg/kg/day orally. The aerobic exercise protocol consisted of treadmill running (6–18 m/min) five days per week for eight weeks. Hippocampal PINK1 and PARKIN expression levels were analyzed.
Results: AD induction significantly reduced PINK1 and PARKIN expression (P < 0.001). Compared to the AD group, significant increases in PINK1 and PARKIN were observed in the ADT (P = 0.043; P = 0.005), ADRSV (P = 0.033; P = 0.046), and ADTRSV (P < 0.001) groups. The ADTRSV group showed higher PINK1 expression than ADT (P = 0.036) and ADRSV (P = 0.046), and greater PARKIN expression than ADRSV (P = 0.046).
Conclusion: Exercise training and RSV supplementation improved hippocampal mitophagy in AD rats, with synergistic effects observed in the combined intervention. These findings suggest that non-pharmacological strategies may mitigate AD-related mitochondrial dysfunction.
Methods: In this experimental study, 35 male Wistar rats were divided into five groups: Control (NO), Alzheimer’s (AD), Alzheimer’s-Training (ADT), Alzheimer’s-Resveratrol (ADRSV), and Alzheimer’s-Training-Resveratrol (ADTRSV). RSV groups received 20 mg/kg/day orally. The aerobic exercise protocol consisted of treadmill running (6–18 m/min) five days per week for eight weeks. Hippocampal PINK1 and PARKIN expression levels were analyzed.
Results: AD induction significantly reduced PINK1 and PARKIN expression (P < 0.001). Compared to the AD group, significant increases in PINK1 and PARKIN were observed in the ADT (P = 0.043; P = 0.005), ADRSV (P = 0.033; P = 0.046), and ADTRSV (P < 0.001) groups. The ADTRSV group showed higher PINK1 expression than ADT (P = 0.036) and ADRSV (P = 0.046), and greater PARKIN expression than ADRSV (P = 0.046).
Conclusion: Exercise training and RSV supplementation improved hippocampal mitophagy in AD rats, with synergistic effects observed in the combined intervention. These findings suggest that non-pharmacological strategies may mitigate AD-related mitochondrial dysfunction.
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