Showing 7 results for Vascular Disease
Hr Joshaghani, Aa Shirafcan, Aj Marjani,
Volume 1, Issue 2 (10-2007)
Abstract
Abstract
Introduction:
methionine. Many reports confirm the correlation between hyper
homocysteinemia and cardiovascular disease. This study was aimed
at determining the effect of B12 and folate deficiency on the
homocysteine level after myocardial infarction.
Homocysteine is produced by demethylation of
Materials and methods:
study were patients with myocardial infarction (N = 48) and healthy
patients (N = 48) Eliza method was used to assay Homocysteine and
RIA for folic acid and vitamin B12.
The subjects of This descriptive-analytic
Results:
(30.3 ± 5.3 μm/l) and the control group (11.1 ± 3.1) is significant (p<
0.001). There is no significant difference between Serum B12 in case
(297.1 ± 208.9 pm/l) and control group (261.5 ± 205.3) and it is true
about Serum folic acid of case (3.9 ± 2.9 ng/m) and control group
(4.3 ± 3.5). The homocysteine level of all patients and four of
healthy subjects is higher than normal. The folic acid Level of 11
patients and four healthy subjects is less than normal.
the difference between the homocysteine Level of the case
Conclusion:
of control group and this difference is not related to decrease of B12
Level, Physicians must pay attention to The other risk factors.
since the homocysteine level of patients is there times
Key words:
cobalamine, cardiovascular disease.
Folic acid, Homocysteine, Myocardial Infarction,
M Rostami, M Jarfi,
Volume 3, Issue 2 (10-2009)
Abstract
Abstract Background and objectives: Smokers are exposed to significant quantities of ROS (Reactive Oxygen Species) and The Level of Nitric Oxide (NO), the primary vasodilator produced by endothelial cells, is changed by cigarette smoking. Cigarette smoking is associated with impaired endothelium-dependent vasodilatation and cardiovascular disease (CVD). The aim of this study is to determine the level of serum nitrite, nitrate and malondialdehyde (MDA) levels in smokers. Material and Methods: In this descriptive analytical study, 60 healthy male smokers and 60 male non-smokers (control group) were selected by a Purposive sampling and then serum levels of nitrite, nitrate and MDA in all patients were determined and compared to together. Results: Serum nitrite and nitrate level in smokers are 10.4±3.1 and 19.6±5.9 and in non-smokers is 14.6±4.4 and 29.3±6.7 (p<0.00001) μmol/L, respectively. The results show that smokers’ are significantly lower than non-smokers’. Serum MDA level in smokers (11.7±2.6 μmol/L) is significantly higher (p<0.00001) than non-smokers (8.3±1.9 μmol/L). Conclusion: Based on the results, serum level of nitrite and nitrate are lower and MDA is higher in smokers. This difference can be related to CVD in smokers. Keywords: Smokers, Non-smokers, Nitrite, Nitrate, Malodialdehyde (MDA), cardiovascular disease (CVD).
Seyyed Manuchehr Nourazarian , Mojtaba Ghaffarian , Homayun Dolatkhah ,
Volume 10, Issue 3 (5-2016)
Abstract
ABSTRACT
Background and Objective: The relationship between diabetes mellitus and increased risk of cardiovascular diseases has been demonstrated. The aim of this study was to determine the fatty acid profile of epicardial adipose tissue in diabetic and non-diabetic patients with cardiovascular disease.
Methods: In this study, 28 diabetic and 40 nondiabetic patients were evaluated. The epicardial adipose tissue and blood samples of patients were collected during surgery. Non‐esterified fatty acids and phospholipids were measured by the thin layer chromatography and gas chromatography.
Results: Saturated free fatty acids (12: 0) level was higher in diabetic patients compared to nondiabetic patients (P=0.038), while saturated free fatty acids (16: 0) was significantly lower in diabetics (P=0.011). Unsaturated fatty acid (20: 3n-9) was higher in nondiabetics compared to diabetics (P=0.015). There was a significant decrease in level of monounsaturated fatty acids in diabetic patients. The epicardial adipose tissue of diabetics showed a significant increase in free fatty acid (18: 0) and conjugated linoleic acid levels, while there was a significant decrease in the level of free fatty acid (18: 1n-11). Level of epicardial omega-3 free fatty acid (20: 5 n-3) and 22: 6 n -3 was significantly reduced in these patients.
Conclusion: Differences in the serum free fatty acid profile of the two groups may be due to differences in their diet, while changes in the fatty acid composition of epicardial adipose tissue in these two groups could be due to impaired metabolism of fatty acids such as uptake, movement and androgen synthesis as a result of diabetes. These changes increase the risk of developing atherosclerosis in diabetic patients.
Maryam Moradi Binabaj, Hamidreza Joshaghani, Mojgan Nejabat,
Volume 10, Issue 5 (9-2016)
Abstract
ABSTRACT
Cardiovascular disease (CVD) is one of the most important causes of mortality worldwide. Several risk factors have been proposed to be associated with CVD. The main risk factors include family history, smoking, hypertension, history of diabetes, hyperlipidemia and obesity. However, new factors have been recently proposed to be associated with CVD. These include blood homocysteine, fibrinogen, plasma factor VII activity, lipoprotein (a) and several other factors. Nowadays, the role of homocysteine in the development and exacerbation of several diseases has been demonstrated. Extensive studies have been performed on the role of homocysteine in diabetes, preeclampsia, depression, Alzheimer's disease and multiple sclerosis. Homocysteine level increases with age. Moreover, absorption of micronutrients, especially vitamin B12, decreases in old age that could cause a further increase in homocysteine level. On the other hand, elasticity of blood vessels decline with aging, and increased levels of homocysteine accelerate atherosclerosis. The sum of these processes highlights the role of homocysteine in the development and exacerbation of several diseases.
Keywords: Homocysteine, Cardiovascular Disease, Diabetes, Preeclampsia, Depression, Alzheimer's Disease.
Hadi Alinejad, Asieh Abbassi Daloii, Parvin Farzanegi, Ahmad Abdi,
Volume 15, Issue 1 (1-2021)
Abstract
Background and Objective: Osteoarthritis (OA) and cardiovascular disease (CVD) are highly prevalent. The purpose of the present study was to investigate the effect of regular aerobic training and hyaluronic acid on cardiac tissue Wnt signaling pathway in experimental model of knee OA.
Methods: 42 male rats were divided into 6 groups (7 in each group): 1) control, 2) patient, 3) salin, 4) HA, 5) exercise, and 6) exercise + HA. In the training groups, the OA model was first induced, followed by 5 days of running on the treadmill for 5 weeks. Hyaluronic acid was injected intra-articularly. After 12 to 14 hours of fasting and 72 hours after the last training session, cardiac tissue sampling was performed for β-catenin and glycogen synthase kinase-3 (GSK-3β) analysis. The expression of the β-catenin and GSK-3β genes in the cardiac tissue was analyzed by RT-PCR. Data analysis was performed using one-way ANOVA if a significant difference was observed by Tukey's post hoc test (P <0.05).
Results: Induction of OA in rats led to a significant increase in β-catenin gene and a significant decrease in cardiac tissue GSK3 gene compared to healthy control group. The results also showed that regular aerobic training, hyaluronic acid injection, and a combination of both treatments reduced the cateninβ gene and increased the cardiac tissue GSK3 gene compared to the rats of OA group.
Conclusion: Regular aerobic training in combination with hyaluronic acid may exert its protective effect by reducing the expression of β-catenin and increasing the expression of cardiac tissue GSK-3β gene ; this may be caused by the heart disease in the model, empirically preventing osteoarthritis.
Toktam Arbabian, Reza Rezaeshirazi, Amin Farzaneh Hesari, Habib Asgharpour,
Volume 15, Issue 4 (7-2021)
Abstract
Background and objectives: Physical activity has long been considered as the cornerstone of interventions for reducing the burden of cardiovascular diseases (CVDs). Homocysteine and obesity indices are important indicators of CVD risk. The present research aimed to evaluate homocysteine and obesity variables in female CVD patients and healthy counterparts with different physical activity levels.
Methods: This study was carried out on 85 CVD patients (40-55 yr, n=41, 60-75 yr, n=44) and 80 healthy women (40-50 yr, n=40, 60-75 yr, n=40). Subjects were divided into three groups based on their physical activity level: sedentary, moderately active and active. Serum homocysteine, body roundness index (BRI), a body shape index (ABSI), body mass index (BMI) and waist circumference (WC) were measured. Data were analyzed using the independent t-test and one-way ANOVA.
Results: Physically active middle-aged CVD patients had significantly lower BRI (p=0.022) and homocysteine (p=0.008) levels compared with the sedentary counterparts. In addition, physically-active old CVD patients had significantly lower BRI (p=0.041), ABSI (p=0.011) and homocysteine (p=0.001) compared with the sedentary counterparts. Physically-active healthy middle-aged individuals had significantly lower BRI (p=0.013) and BMI (p=0.008) levels compared with sedentary counterparts. Active elderly subjects also had significantly lower BRI (p=0.001) and WC (p=0.008) compared with the sedentary counterparts.
Conclusion: Physical activity can reduce the risk of CVD and improve health status of women by reducing homocysteine, BRI and ABSI.
Hassan Esmaeili, Samaneh Shams Nateri, Mohsen Ebrahimi,
Volume 17, Issue 6 (11-2023)
Abstract
Background: Kawasaki disease (KD) is a febrile systemic vasculitis that affects children. Further research is required due to the disease's significance, consequences, and increasing prevalence. This study aimed to determine the frequency of coronary artery complications in patients with KD referred to Taleghani Hospital (Gorgan, Iran) from 2007 to 2017.
Methods: Between 2007 and 2017, 108 cases with a definitive diagnosis of KD were studied retrospectively. Data were obtained from medical records and the patients' biographical, clinical, laboratory, radiographic, and echocardiographic data.
Results: A total of 108 patients diagnosed with KD were involved in the study, 21 (19.44%) of whom showed coronary artery-associated complications. There was no significant difference in clinical and laboratory findings and coronary artery involvement between male and female groups (P-value < 0.05). Left coronary artery (LCA) involvement and the pattern of vascular involvement as ectasia and aneurysm were significantly higher in the echocardiography of the studied patients (P-value = 0.0001).
Conclusion: Kawasaki disease-related coronary artery complication is more common in children under the age of 3, particularly males, in Gorgan. The LCA is the most common site of coronary artery complications in KD children. The findings can improve the prognosis of KD patients and their related heart diseases.
