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Showing 4 results for Superoxide Dismutase
The Alterations of Plasma Iipid Peroxidation and erythrocyte Superoxide Dismutase and Glutathione Peroxidase Enzyme Activities During Storage of Blood
A Marjani, A.r. Mansoorian, H. R. Joshaghani, K Heydari, A Sarikhani,,
Volume 1, Issue 1 (4-2007)
Abstract

Abstract Background and objective: Exposure of red blood cells to oxygen radicals can induce Lipid proxidation, hemoglobin damage and hemolysis of erythrocyte .The present study was designed to determine the alteration of plasma lipid peroxidation and erythrocyte Superoxide Dismutase and Glutathione Peroxidase enzyme activities in stored blood and to find out the quantitative alterations and the useful length of stored blood. Materials and Methods: First, the whole blood form 10 donors was taken. Then Red Blood Cells(RBC) were counted, the levels of Potassium(P) and lactate dehydrogenate activity(LDH) were measured to determine the amount of hemolysis, the plasma levels of malondialdehyde (MDA), erythrocyte Superoxide Dismutase(SOD) and Glutathione Peroxidase(GPx) were studied for determination of lipid peroxidation and antioxidant enzyme activities at the days of 0,1,3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33 and 35 of the storage. Results: upon storage time, the plasma levels of malondialdehyde (MDA) and Potassium and lactate dehydrogenate activity increased (P< 0.05) whereas erythrocyte Superoxide Dismutase and Glutathione Peroxidase enzyme activities and Red Blood Cells decreased (P< 0.05). The alterations of MDA, SOD, GPx, P, LDH and RBC in the measurement days were as follows: MDA, P and LDH significantly increased at the day of 9, 5 and 5 whereas SOD, GPx and RBC decreased at the day of 11, 7 and 29 respectively. Conclusion: The results of this study showed that the increased level of MDA and decreased SOD and GPx in stored blood can cause the beginning of hemolysis of erythrocyte therefore, it is necessary to control these factors before storing the donated blood. Keywords: lipid peroxidation, Superoxide Dismutase, Glutathione Peroxidase


Increased Serum Superoxide Dismutase and Catalase Activities in Streptozotocin-Induced Diabetic Rats
E Kharazi-Nejad, A Nakhaee, M Taheri,
Volume 7, Issue 4 (1-2014)
Abstract
Abstract Background and Objective: One of the diabetes complications is the tissue damage caused by the imbalance of oxidants and antioxidants (oxidative stress). The aim of the present study was to evaluate the activity of two antioxidant enzymes -superoxide dismutase and catalase- in the serum of streptozotocin-induced diabetic rats. Material and Methods: This investigation was conducted on adult male rats assigned to diabetic and control groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Seven weeks after diabetes induction, glucose concentration, superoxide dismutase and catalase activities of the serum were assessed. Results: Glucose concentration of streptozotocin-injected animals was significantly higher than that of control group (P<0.001). The level of Serum superoxide dismutase and catalase activities in diabetes group were significantly higher than those in control group (P<0.01). There was a positive significant correlation between glucose concentration and superoxide dismutase and catalase activities (P<0.001). Conclusion: The high activity of antioxidant enzymes in diabetic rats is probably due to compensation responses to oxidative stress produced by high concentration of free radicals. It seems that the higher glucose concentration, the greater compensatory responses. Keywords: Diabetes, Streptozotocin, Antioxidant, Superoxide Dismutase, Catalase
Effect of Six Weeks of Swimming Training on Malondialdehyde and Superoxide Dismutase Levels in the Heart Tissue of Mice with Breast Cancer
Behnaz Vanaky, Nader Shakeri, Hojat Allah Nikbakht, Parvin Farzanegi,
Volume 12, Issue 3 (5-2018)
Abstract
ABSTRACT
         Background and Objectives: Breast cancer is one of the most common cancers among women. Cardiovascular disease is one of the most important complications of breast cancer. The aim of this study was to investigate the effects of six weeks of swimming on malondialdehyde (MDA) and superoxide dismutase (SOD) levels in the heart tissue of mice with breast cancer.
         Method: Breast cancer was induced in 30 female Balb/c mice (6-8 weeks old, weighing 150-200 g) by tumor transplantation. The tumor site was examined every day for the formation or absence of tumor. After becoming familiar with the laboratory environment and swimming pool, the subjects were randomly divided into three equal groups: 1. healthy control, 2. cancer control, and 3. swimming-cancer. The swimming group performed swimming training 60 minutes/day, five days a week, for six weeks. After the intervention, the levels of SOD and MDA in the heart tissue samples were evaluated by enzyme-linked immunosorbent assay. Data were analyzed in SPSS (version 16) using independent t-test at significance of 0.05.
         Results: The results showed that induction of breast cancer was accompanied by a significant increase in MDA and a significant decrease in SOD in the heart tissue of mice. Participation in the six-week swimming significantly reversed these effects.
         Conclusion: Swimming could have beneficial effects in improving oxidative factors in breast cancer patients.
         Keywords: Breast Neoplasms, Heart, Malondialdehyde, Superoxide Dismutase, Swimming.

Effects of Taurine Supplementation during Endurance Training on Antioxidant Activity in Males
Sajad Jafari, Mohammad Fathi, Masoud Rahmati,
Volume 17, Issue 3 (5-2023)
Abstract
Background and objectives: Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress. The present study was designed to investigate the effects of taurine supplementation on lipids peroxidation and antioxidant activity during endurance activities. 
Methods: Twenty-four male volunteers aged 27 ± 1.8 years and weighting 74.9 ± 5.9 kg were randomly divided into three groups: taurine supplementation (n=8), placebo (n=8), and control (n=8). The subjects completed a 28-day endurance training protocol. Biochemical parameters such as superoxide dismutase (SOD), glutathione peroxidase (GPX) activities, as well as malondialdehyde (MDA) concentrations (8 hours before the first session and 8 hours after the last session) and maximum rate of oxygen consumption, were measured to evaluate the antioxidant, lipid peroxidation, and VO2 max status respectively. Finally, data were analyzed by SPSS software at a significance level of <0.05.
Results: Taurine supplementation significantly increased SOD (p=0.001) and GPX (p=0.001) but significantly decreased MDA (p=0.001). However, it had no significant effect on the VO2 max. 
Conclusion: The results of the present study indicate that taurine has antioxidant effects against endurance exercise-induced oxidant stress and lipid peroxidation.
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