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Showing 6 results for Homocysteine
Plasma Level of Homocysteine, Folic acid and Cobalamine in Patients suffered from myocardial infarction
Hr Joshaghani, Aa Shirafcan, Aj Marjani,
Volume 1, Issue 2 (10-2007)
Abstract

Abstract

Introduction:

methionine. Many reports confirm the correlation between hyper

homocysteinemia and cardiovascular disease. This study was aimed

at determining the effect of B12 and folate deficiency on the

homocysteine level after myocardial infarction.

Homocysteine is produced by demethylation of

Materials and methods:

study were patients with myocardial infarction (N = 48) and healthy

patients (N = 48) Eliza method was used to assay Homocysteine and

RIA for folic acid and vitamin B12.

The subjects of This descriptive-analytic

Results:

(30.3 ± 5.3 μm/l) and the control group (11.1 ± 3.1) is significant (p<

0.001). There is no significant difference between Serum B12 in case

(297.1 ± 208.9 pm/l) and control group (261.5 ± 205.3) and it is true

about Serum folic acid of case (3.9 ± 2.9 ng/m) and control group

(4.3 ± 3.5). The homocysteine level of all patients and four of

healthy subjects is higher than normal. The folic acid Level of 11

patients and four healthy subjects is less than normal.

the difference between the homocysteine Level of the case

Conclusion:

of control group and this difference is not related to decrease of B12

Level, Physicians must pay attention to The other risk factors.

since the homocysteine level of patients is there times

Key words:

cobalamine, cardiovascular disease.

Folic acid, Homocysteine, Myocardial Infarction,
Homocystein Level and Total Antioxidant Capacity in Chronic Obstructive Pulmonary Disease
Ms Shirakdehi, M Rezaei, E Nadi, H Mahjoub, Mt Goodarzi,
Volume 8, Issue 1 (4-2014)
Abstract
Abstract Background and Objective: Oxidant-antioxidant imbalance plays a key role in pathogenesis of chronic obstructive pulmonary disease (COPD). This study aimed to evaluate homocystiene and total antioxidant capacity in COPD patients, compared to smoker and non-smoker healthy people. Material and Methods: We measured total antioxidant capacity with Cayman Kit, uric acid with Pars Azmoon kit٫ homocysteine with ELISA Kit and inflammatory cells (leukocytes) in 29 COPD patients, 29 smokers and 29 non-smokers. Results: Uric acid was significantly higher in COPD patients compared to healthy smokers and healthy non-smokers (p<0.05). Total antioxidant capacity was significantly lower in COPD patients compared to healthy, non smokers (p=0. 003). In COPD patients, homocysteine and leukocytes levels were significantly higher than those in healthy smokers (P<0.05) and healthy non- smokers (p<0.001). Conclusion: According to high inflammatory cells and low antioxidant capacity in COPD, early administration of appropriate medication is recommended to reduce systemic and topical inflammation. Reduction in the exposure to oxidizing compounds can slow the process of degradation and damage to lungs. Keywords: Chronic Obstructive Pulmonary Disease Homocysteine Oxidative Stress
Role of Homocysteine in Diseases: A Review
Maryam Moradi Binabaj, Hamidreza Joshaghani, Mojgan Nejabat,
Volume 10, Issue 5 (9-2016)
Abstract

ABSTRACT

         Cardiovascular disease (CVD) is one of the most important causes of mortality worldwide. Several risk factors have been proposed to be associated with CVD. The main risk factors include family history, smoking, hypertension, history of diabetes, hyperlipidemia and obesity. However, new factors have been recently proposed to be associated with CVD. These include blood homocysteine, fibrinogen, plasma factor VII activity, lipoprotein (a) and several other factors. Nowadays, the role of homocysteine in the development and exacerbation of several diseases has been demonstrated. Extensive studies have been performed on the role of homocysteine in diabetes, preeclampsia, depression, Alzheimer's disease and multiple sclerosis. Homocysteine level increases with age. Moreover, absorption of micronutrients, especially vitamin B12, decreases in old age that could cause a further increase in homocysteine level. On the other hand, elasticity of blood vessels decline with aging, and increased levels of homocysteine accelerate atherosclerosis. The sum of these processes highlights the role of homocysteine in the development and exacerbation of several diseases.

         Keywords: Homocysteine, Cardiovascular Disease, Diabetes, Preeclampsia, Depression, Alzheimer's Disease.


Effects of Eight Weeks of Aerobic Exercise on Visfatin, Homocystein, C - reactive protein and Lipid Profile in Sedentary Men
Nagmeh Alsabah Alavizadeh , Keyvan Hejazi, Tohid Mabhout Moghadam ,
Volume 12, Issue 4 (7-2018)
Abstract
ABSTRACT
          Background and objectives: Visfatin is a newly characterized adipokine, which is highly expressed in visceral adipose tissue. The aim of this study was to evaluate effects of aerobic exercise training on visfatin, homocystein, C-reactive protein and lipid profile in sedentary men.
          Methods: In this quasi-experimental study, 27 sedentary men were selected by convenience sampling method. The subjects were divided into a control group (n=13) and an aerobic training group (n=14). The subjects in the experimental group performed 60 minutes of aerobic exercise at 75-85% of maximum heart rate, three sessions per week for eight weeks. Data were analyzed in SPSS 16.0 (SPSS Inc., Chicago, IL, USA) using paired and independent sample t-test for comparison of means within and between groups, respectively. A P-value of less than 0.05 was considered statistically significant.
          Results: The eight-week aerobic exercise training significantly reduced body weight (P=0.02), body mass index (P=0.01) and low-density lipoprotein-cholesterol (P=0.03) levels. It also caused a significant increase in the high-density-lipoprotein-cholesterol (P=0.00) and a significant decrease in visfatin levels (P=0.005). Serum homocysteine and C-reactive protein levels decreased by the end of the training program, but these changes were not statistically significant (P>0.05).
          Conclusion: The eight-week aerobic exercise program could effectively improve lipid profile and visfatin levels. Therefore, this type of exercise could be recommended for prevention of cardiovascular disease and improvement of its risk factors.
          Keywords: Aerobic, C-reactive protein, Exercise, Homocysteine.

Does Physical Activity Level Affect Homocysteine and Obesity Variables in Women with Cardiovascular Disease?
Toktam Arbabian, Reza Rezaeshirazi, Amin Farzaneh Hesari, Habib Asgharpour,
Volume 15, Issue 4 (7-2021)
Abstract
Background and objectives: Physical activity has long been considered as the cornerstone of interventions for reducing the burden of cardiovascular diseases (CVDs). Homocysteine and obesity indices are important indicators of CVD risk. The present research aimed to evaluate homocysteine and obesity variables in female CVD patients and healthy counterparts with different physical activity levels.
Methods: This study was carried out on 85 CVD patients (40-55 yr, n=41, 60-75 yr, n=44) and 80 healthy women (40-50 yr, n=40, 60-75 yr, n=40). Subjects were divided into three groups based on their physical activity level: sedentary, moderately active and active. Serum homocysteine, body roundness index (BRI), a body shape index (ABSI), body mass index (BMI) and waist circumference (WC) were measured. Data were analyzed using the independent t-test and one-way ANOVA.
Results: Physically active middle-aged CVD patients had significantly lower BRI (p=0.022) and homocysteine (p=0.008) levels compared with the sedentary counterparts. In addition, physically-active old CVD patients had significantly lower BRI (p=0.041), ABSI (p=0.011) and homocysteine (p=0.001) compared with the sedentary counterparts. Physically-active healthy middle-aged individuals had significantly lower BRI (p=0.013) and BMI (p=0.008) levels compared with sedentary counterparts. Active elderly subjects also had significantly lower BRI (p=0.001) and WC (p=0.008) compared with the sedentary counterparts.
Conclusion: Physical activity can reduce the risk of CVD and improve health status of women by reducing homocysteine, BRI and ABSI.
Relationship between hyperhomocysteinemia and the development of diabetes mellitus and cardiovascular disorders in Indian adult patients
Misha Antani, Anjali Goyal, Jalashree Rana,
Volume 18, Issue 1 (1-2024)
Abstract
Background: A higher occurrence of raised homocysteine levels has been reported in individuals with type 2 diabetes (T2D), particularly those with macroangiopathy and nephropathy. Given that hyperhomocysteinemia is a risk factor for T2D, mitigating this condition could potentially benefit T2D patients. This study aimed to investigate the influence of homocysteine on T2D and cardiovascular disease (CVD), as well as the factors that modify homocysteine levels.
Methods: This cross sectional, observational study was conducted on 122 individuals in a tertiary care center in Western India. Data related to anthropometry, demography, and biochemistry were gathered following established standards. Statistical analysis was performed using Chi-square test. A P-value of <0.05 was considered statistically significant.
Results: The findings indicated a significantly larger percentage of hyperhomocysteinemia in males, smokers, and individuals with elevated fasting blood sugar and HbA1c levels. The proportion of subjects with high homocysteine levels was notably greater in those with high total cholesterol and triglyceride levels. A significant correlation was observed between increased serum homocysteine levels and decreased serum folic acid and vitamin B12 levels in patients with ischemic heart disease.
Conclusion: Elevated homocysteine levels are observed in smokers and diabetic patients, potentially leading to CVD. Furthermore, this study found a correlation between an increase in serum homocysteine levels and a decrease in serum folic acid and vitamin B12 levels in patients with ischemic heart disease.
 
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