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Effects of Methanolic Extract of Ficus carica Leaves on Cystic Echinococcosis
Jaber Ali Poor , Mansor Dabirzadeh, Yahya Marofi , Seyed Ali Asghar Sefidgar,
Volume 11, Issue 3 (5-2017)
Abstract
ABSTRACT
          Background and objective: Surgery is the gold standard treatment for hydatidosis. Scolicidal agents could be used during surgery to kill protoscoleces and prevent cyst recurrence after rupturing of main lesion. Non-chemical agents with sufficient protoscolex-killing activity are known to be fully effective in this regard with fewer side effects. Fig tree is an Iranian native plant, which has been used for medicinal purposes in traditional medicine.
          Methods: After obtaining infected hydatid cyst of the liver from a slaughterhouse in Babol (Iran), the percentage of live protoscoleces was calculated by critical staining with 0.1 % eosin. Then, the protoscolex-killing activity of methanolic extract of fig leaves was evaluated at concentrations of 2.5, 5, 10, 15 and 20 mg/ml in 2, 4, 8, 12, and 16 minutes exposure times. Statistical analysis was performed using SPSS software (version 22).
          Results: Concentration of 20 mg/ml of the extract showed 100% protoscolex-killing activity within the first 2 minutes of exposure. In addition, the lowest protoscolex-killing activity (45%) was observed at concentration of 2.5 mg/ml after 2 minutes. The results also showed that the protoscolex-killing activity of the extract increases significantly in a concentration- and time-dependent manner (P <0.001).
         Conclusion: The methanolic extract of fig leaf at concentration of 20 mg/ml could exert significant scolicidal effect within 2 minutes of exposure. Therefore, complementary experiments should be performed on animal models to further assess the efficiency of the extract for killing protoscoleces of hydatid cyst during surgery.
          Keywords: Echinococcus granulosus, methanolic extract of Ficus carica, broth dilution. 

Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbits
Piyushkumar Mansinh Pargi , Manish Barvaliya , Bhargav Purohit,
Volume 18, Issue 4 (7-2024)
Abstract
Background: Although the anti-diabetic effects of various Ficus species have been investigated in animal models, research on the blood glucose-lowering potentials of Ficus lacor Buch Ham bark remains sparse. This study evaluated the blood glucose-lowering potentials of an aqueous extract derived from Ficus labor bark in a diabetic rabbit model.
Methods: Diabetes was induced in rabbits through intravenous administration of alloxan monohydrate (120 mg/kg). 36 rabbits were divided into six groups, each consisting of six animals. Control groups included a non-diabetic control (Distilled water) and a diabetic control (Distilled water). Two experimental groups received Ficus lacor extract at doses of 100 mg/kg (Low-dose) and 200 mg/kg (High-dose) orally for six weeks. Metformin was used as an active control. A non-diabetic group (Extract control) was also administered Ficus lacor extract at 200 mg/kg. Fasting blood sugar (FBS) and post-prandial blood sugar (PP2BS) levels were measured weekly over the 6 weeks. The percentage reduction in blood glucose levels was calculated and compared for each group.
Results: The administration of both low-dose and high-dose Ficus lacor extracts resulted in significant reductions in FBS and PP2BS levels in diabetic rabbits. After six weeks, the low-dose extract group exhibited an average reduction of 38.3% in FBS and 40.5% in PP2BS, whereas the high-dose extract group showed average reductions of 35.3% in FBS and 36.3% in PP2BS.
Conclusion: The aqueous extract of Ficus lacor bark demonstrates substantial glucose-lowering activity, indicating its potential utility as a therapeutic agent in diabetes management.

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