Abstract
Introduction:
methionine. Many reports confirm the correlation between hyper
homocysteinemia and cardiovascular disease. This study was aimed
at determining the effect of B12 and folate deficiency on the
homocysteine level after myocardial infarction.
Homocysteine is produced by demethylation of
Materials and methods:
study were patients with myocardial infarction (N = 48) and healthy
patients (N = 48) Eliza method was used to assay Homocysteine and
RIA for folic acid and vitamin B12.
The subjects of This descriptive-analytic
Results:
(30.3 ± 5.3 μm/l) and the control group (11.1 ± 3.1) is significant (p<
0.001). There is no significant difference between Serum B12 in case
(297.1 ± 208.9 pm/l) and control group (261.5 ± 205.3) and it is true
about Serum folic acid of case (3.9 ± 2.9 ng/m) and control group
(4.3 ± 3.5). The homocysteine level of all patients and four of
healthy subjects is higher than normal. The folic acid Level of 11
patients and four healthy subjects is less than normal.
the difference between the homocysteine Level of the case
Conclusion:
of control group and this difference is not related to decrease of B12
Level, Physicians must pay attention to The other risk factors.
since the homocysteine level of patients is there times
Key words:
cobalamine, cardiovascular disease.
Folic acid, Homocysteine, Myocardial Infarction,
