Showing 4 results for Burns
Maryam Meskini , Azad Khaledi , Davoud Esmaeili ,
Volume 13, Issue 1 (1-2019)
Abstract
ABSTRACT
Background and Objectives: Pseudomonas aeruginosa is a gram negative opportunistic pathogen and an important cause of wound infections and nosocomial infections. The purpose of this study was to study inhibitory effects of a new ointment prepared from medicinal plants against P. aeruginosa isolates.
Methods: In this study, an ointment called ZOUSH was prepared from mixing alcoholic extracts of Satureja khuzestaniea, Zataria multiflora, Mentha mozaffariani Jamzad, honey and polyurethane. Minimal inhibitory concentration of ZOUSH and its compositions alone or combined was determined using the disk diffusion method.
Results: S. khuzestaniea, Z. multiflora and Mentha mozaffariani Jamzad had inhibitory effects against P. aeruginosa. The ZOUSH ointment had greater antibacterial effects than the any of its compositions used solely or combined. The diameter of inhibition zone had a direct relationship with the concentration of the extracts. Moreover, the antibacterial effect of the ZOUSH ointment was identical to that of polymyxine B (300 µg).
Conclusion: We demonstrated that the ZOUSH ointment has inhibitory effects against P. aerugionosa. The inhibition zone diameter is directly correlated with the concentration of the extracts. Our results suggest that the ointment could be useful for treatment of burn wounds and skin infections.
Amir Abbas Barzegari, Masood Hashemzaei, Ali Reza Aslihematti,
Volume 13, Issue 2 (3-2019)
Abstract
ABSTRACT
Background and Objectives: Current medications used for the treatment of burn wounds have some side effects and disadvantages. Oral or topical administration of probiotic bacteria is thought to be useful for treatment of skin disorders. The aim of this study was to evaluate effects of spray-dried Streptococcus thermophilus on healing of second-degree burn wounds.
Methods: After induction of second-degree burn on back of 80 male Wistar rats, the animals were randomly allocated to negative control (no treatment), first vehicle control (treatment with Eucerin), second vehicle control (treatment with skim milk) and experimental (treatment with bacterial ointment) groups. Wound healing rate (percent) and histopathological parameters of wound samples were evaluated on post-burn days 1, 3, 7 and 14.
Results: On days 3 and 7, macroscopic results showed that the healing rate was significantly higher in the experimental group compared to the control groups. Histopathological analysis of wound samples showed increased fibroblastic migration, collagen formation and re-epithelialization in the wounds treated with probiotic bacteria compared with the wounds of control groups.
Conclusion: Our results indicate that the topical use of spray-dried S. thermophilus could be useful for the treatment of burn wounds.
Keywords: Streptococcus thermophilus; Probiotics; Burns; Wound Healing; Rats.
Mobina Hosseini, Meysam Hasannejad-Bibalan, Tofigh Yaghoubi, Mohammadreza Mobayen, Parisa Khoshdoz, Sara Khoshdoz, Niloofar Faraji, Hadi Sedigh Ebrahim-Saraie,
Volume 15, Issue 6 (11-2021)
Abstract
Background and objectives: Bacterial contamination of wounds is a serious problem, particularly in burn patients. Gram-positive bacteria are the predominant cause of infection in newly hospitalized burn cases. This study aimed to survey the prevalence and antibiotic resistance pattern of gram-positive bacterial isolates among burn patients in Rasht, North of Iran.
Methods: This cross-sectional study was conducted on burn patients with a positive culture for gram-positive isolates who were hospitalized in the Velayat Burn Center in Rasht, North of Iran, during 2017-2020. The isolates were identified using standard microbiological methods. Moreover, the antibiotic resistance pattern was determined by the disk diffusion method.
Results: During the study period, 671 bacterial cultures were obtained, of which a total of 16 gram-positive isolates were taken from the patients. The frequency of coagulase-negative staphylococci (CoNS), Staphylococcus aureus, and Enterococcus spp. was 68.7%, 18.8%, and 12.5%, respectively. In addition, the highest rate of resistance in CoNS isolates was against trimethoprim/sulfamethoxazole. The highest rate of resistant among S. aureus isolates was recorded against penicillin. Moreover, Enterococcus faecalis isolates showed a high level of resistance to ampicillin, erythromycin, tetracycline, gentamicin, and ciprofloxacin. All isolates were susceptible to teicoplanin. Moreover, the frequency of methicillin-resistant S. aureus isolates was 66.7%.
Conclusion: Given the increasing prevalence of drug-resistant strains, especially in susceptible burn patients, it is imperative to analyze the bacterial etiology of nosocomial infections periodically and epidemiologically.
Suresh Jaiswal, Bijay Subedi, Ashmita Sapkota, Pushpa Sharma, Manisha Timilsina, Maheshwor Timilsina, Bishnu Raj Tiwari,
Volume 18, Issue 1 (1-2024)
Abstract
Background: Intestinal infections with Helicobacter pylori mainly occur during childhood. If contracted, these infections may cause chronic gastritis, frequently leading to peptic ulcer disease in later life. This study aims to detect the prevalence of H. pylori infections in patients with active gastritis.
Methods: The study included 150 participants who were consuming daily anti-gastritis drugs to reduce the gas and were considered active gastritis patients and were recruited from Lekhnath 12, now known as Pokhara metropolitan-30, from May 2018 to March 2019. They were screened for H. pylori antibodies for detection of infection by the immunochromatographic rapid detection kit, and the data were analyzed using SPSS 2016.
Results: Serum anti-Helicobacter pylori antibodies were used to detect the presence of Helicobacter pylori in these participants. Among the 150 participants, 54 were males (36%) and 96 were females (64%). The results showed that 47 (31.3%) of the patients were positive for anti-Helicobacter pylori test. The age group 30 to 40 had the highest prevalence of 21 (14.0%). Using public water showed the highest prevalence with a P value of 0.04.
Conclusion: There should be an additional aspect required for the diagnosis and treatment of gastritis, which is the healthcare providers' and patients' awareness of the cause and most efficient treatments for this medical condition. Using only anti-gastritis drugs is not sufficient; treatment against Helicobacter pylori requires the right pathway of treatment by the use of several antibiotics.
