Showing 2 results for Atopic Dermatitis
Mr Bonyadi, F Ezzati,
Volume 8, Issue 2 (7-2014)
Abstract
Abstract
Background and objective: Being exposed to different allergens, followed by the production of specific IgE, has an important role in causing atopic dermatitis, recognizing the allergens and applying immunotherapy for treatment. We aimed to determine the frequency of common allergens in the patients suffering from atopic dermatitis.
Material and Methods: In this descriptive- analytical study the serum level of total IgE and frequency of specific IgE were measured by Immunoblotting method against 20 common allergens in 150 atopic dermatitis patients in 2010-2011 .The control group included the individuals who have been diagnosed healthy.
Result: The mean age was 30.02±14.79 the participants were male (77 51.3%) and female (73 48.7%). In 90% of patients, total IgE was more than the reference range with the mean of 227.51±103IU/ml. The most frequent allergens related to: Cultivated rye (48.6%), Timothy grass (42.9%), House dust mite (22.7%), Cat (16.7%), Horse (10%), Birch (11.33%), Potato (11.33%), Dog (16.7%), Egg white (8.7%), Cow milk (8.7%). The frequency of positive allergens in plants and fungus group was 54.34%, in animals was 26.8% and in foods was 19.56%. In control group, there was no total IgE elevation.
Conclusion: Based on the recognition of common allergens in east Azerbayjan, Iran, we recommend avoiding of these allergens and providing immunotherapy.
Keywords: Atopic Dermatitis, Allergen, Specific IgE, Total IgE
Mohammad Sadegh Naghizadeh, Mohsen Naseri, Gholamreza Anani Sarab, Afshin Derakhshani, Mohammad Fereidouni,
Volume 17, Issue 6 (11-2023)
Abstract
Background: Atopic dermatitis (AD) is a common allergic disorder. Detection of responsible pathogenic allergens in AD patients by reliable methods has a fundamental role in the prevention, management, and treatment of AD. This study was conducted to determine the most common allergens by the skin prick test (SPT) and immunoblotting among AD patients referring to an allergy clinic in Birjand City, Iran.
Methods: The presence of AD was confirmed by an expert allergist. Serum levels of total and specific immunoglobulin E (sIgE) against 30 food and inhalant allergens were evaluated by a commercial immunoblotting kit (AlleisaScreen).
Results: The skin prick test was performed by a battery of 17 allergens. In total, 34 AD patients (mean age, 28.76 ± 17.36 years; range, 1-60 years; F/M ratio: 0.88) were enrolled in this study. The sensitization rates to at least 1 fungus, pollen, food, or indoor allergen by the immunoblotting method were 32.35%, 61.76%, 52.94%, and 47.05%, respectively. The most prevalent allergens were ragweed (52.94), Olive tree (41.16), Eucalyptus (35.29), date palm (35.29), and grass mix (32.28).
Conclusion: The study found that 85.29% of the studied population were sensitized to at least 1 allergen. Pollens and date palms were the most common allergens among AD patients, but the pattern of sensitization in SPT and immunoblotting was not exactly similar. Detection of allergens to which patients are sensitized and avoidance can help in the management of the disease and its symptoms.
