Showing 4 results for Atherosclerosis
Z Shahandeh, F Sedighian, Mt Salehi Omran, F Saberian,
Volume 3, Issue 1 (4-2009)
Abstract
Abstract Background and objectives: Coronary Artery Disease is one of the most important causes of death in the world. Atherosclerosis is a complex disorder and many factors cause it . In recent years , a relationship between infectious agents, particularly Chlamydia pneumonia, and atherosclerosis was found. This research was aimed at serological studying of Chlamydia pneumonia in the coronary artery patients and healthy ones. Material and Methods: We carried out this cross-Sectional study on 102 patients with CAD and 142 individuals without any history of CAD. The subjects were admitted to Dr. Beheshty hospital, Babol, from July 2005 to September 2006. The subjects’ serums were collected to detect specific anti Chlamydia pneumonia antibodies (IgA and IgG), using ELISA method. Data were analyzed by chi-square, using SPSS software. Results: The mean age of patients and healthy subjects were 60.6 and 43.7 years, respectively. Fifty-nine point eight percent of cases and 40.8% of healthy subjects are men. The results show that 45.1% of patients and 47.9% of healthy subjects have positive titer of IgG and negative titer of IgA (chronic). There is no significant correlation between patient and healthy groups (P=O.698). Also 88.2% of patients and 81% of healthy group have positive titer of anti Chlamydia pneumonia antibody (IgG). Conclusion: In spite of high titer of IgG, there is no significant relationship between Chlamydia pneumonia and atherosclerosis. It seems that further experiments are necessary to prove the relationship between Chlamydia and atherosclerosis. Key words: Atherosclerosis, Chlamydia pneumonia, IgA, IgG
E Abdollahi, F Tavasolian, M Samadi,
Volume 8, Issue 3 (8-2014)
Abstract
Abstract
Background and Objective: Atherosclerosis is an inflammatory disease mostly caused by oxidation of low density lipoproteins (LDLs) while High-density lipoproteins (HDLs) oppose atherosclerosis by inhibiting the oxidation of LDLs. Serum concentration of C- reactive protein (CRP) also increases as an acute phase protein in inflammatory conditions like atherosclerosis. We aimed to evaluate the relationship between serum levels of HDL and CRP in patients with atherosclerosis disease.
Material and Methods: CRP and HDL in 45 patients as a case and 45 healthy individuals as a control group were measured in the central laboratory of Yazd city. The CRP was measured by turbidometric quantitative method and HDL by colorimetric method.
Results: In case group, the CRP level was 7.62 ± 4.08 mg/l and the HDL level was 45.29 ± 9.41mg/dl, which are inversely correlated (P-value: 0.001, Pearson correlation: -0.700), while the correlation in control group was not significant (P-value: 0.88, Pearson correlation: 0.023).
Conclusion: Based on the resuls, there is a significant inverse correlation between CRP and HDL in atherosclerotic patients.
Keywords: Atherosclerosis Disease, CRP, HDL
Seyyed Manuchehr Nourazarian , Mojtaba Ghaffarian , Homayun Dolatkhah ,
Volume 10, Issue 3 (5-2016)
Abstract
ABSTRACT
Background and Objective: The relationship between diabetes mellitus and increased risk of cardiovascular diseases has been demonstrated. The aim of this study was to determine the fatty acid profile of epicardial adipose tissue in diabetic and non-diabetic patients with cardiovascular disease.
Methods: In this study, 28 diabetic and 40 nondiabetic patients were evaluated. The epicardial adipose tissue and blood samples of patients were collected during surgery. Non‐esterified fatty acids and phospholipids were measured by the thin layer chromatography and gas chromatography.
Results: Saturated free fatty acids (12: 0) level was higher in diabetic patients compared to nondiabetic patients (P=0.038), while saturated free fatty acids (16: 0) was significantly lower in diabetics (P=0.011). Unsaturated fatty acid (20: 3n-9) was higher in nondiabetics compared to diabetics (P=0.015). There was a significant decrease in level of monounsaturated fatty acids in diabetic patients. The epicardial adipose tissue of diabetics showed a significant increase in free fatty acid (18: 0) and conjugated linoleic acid levels, while there was a significant decrease in the level of free fatty acid (18: 1n-11). Level of epicardial omega-3 free fatty acid (20: 5 n-3) and 22: 6 n -3 was significantly reduced in these patients.
Conclusion: Differences in the serum free fatty acid profile of the two groups may be due to differences in their diet, while changes in the fatty acid composition of epicardial adipose tissue in these two groups could be due to impaired metabolism of fatty acids such as uptake, movement and androgen synthesis as a result of diabetes. These changes increase the risk of developing atherosclerosis in diabetic patients.
Farnaz Zahedi Avval, Malihe Moammeri Salahshooh, Fatemeh Sadabadi,
Volume 14, Issue 2 (3-2020)
Abstract
ABSTRACT
Reports have shown that lipoprotein (Lp)(a) can serve as an indicator of atherosclerosis and cardiovascular diseases. Several cardiovascular disease risk factors including age, ethnicity and type 2 diabetes mellitus have been linked to Lp(a) metabolism. Given the structural similarity between Lp(a) and plasminogen, there may be a relationship between Lp(a) level and thrombosis and atherogenesis.
In this review, we summarize the latest data about Lp(a) and related conditions on the PubMed database using the following keywords: “Lp(a) and diseases” and “Lp(a) and racial groups”. All available information was extracted and categorized according to the purpose of this study. In conclusion, evidence suggest that increased level of Lp(a) results in coronary artery disease and increases the risk of ischemic stroke. Lack of Lp(a) has no adverse effect on human health. Moreover, Lp(a) can be effective in wound healing as it degrades apolipoprotein(a) products which might have anti-tumor and anti-angiogenetic effects.
Keywords: Lipoprotein(a), Atherosclerosis, Apo(a).
