Mehdi Seydyousefi , Ziya Fallahmohammadi , Mahtab Moazzami , Ali Yaghoubi , Zeinab Faghfoori ,
Volume 13, Issue 2 (Mar-Apr 2019)
Abstract
ABSTRACT
Background and objectives: Stroke is one of the leading causes of death and long-term acquired disability. It is of great importance to seek ways for improving motor, sensory, and cognitive function after stroke and brain injury. In this regard, therapeutic exercise is the most commonly used method of rehabilitation that can significantly reduce the severity of functional damage. The aim of the present study was to investigate effects of eight weeks of forced treadmill training on cognitive and motor functions in ischemic rats.
Methods: Fourteen adult male Wistar rats were divided into an exercise group and a control group (no exercise). Occlusion of both common carotid arteries was made to induce cerebral ischemia. Twenty-four hours after the induction of ischemia, the subjects in the exercise group were subjected to treadmill running, five days a week for eight weeks. The skilled ladder rung walking task was used to evaluate motor function before and after the stroke.
Results: The number of errors was decreasing in both groups, but significant differences were observed in the motor function between the two groups in the third, fifth, and eighth week.
Conclusion: Our results suggest that post-ischemic exercise might modulate ischemia-induced hippocampal injury and ameliorate the subsequent memory and motor impairment.
Keywords: Stroke, Cerebral Ischemia, Exercise, Treadmill training, sensorimotor.
Noosha Amiri, Mahtab Moazzami, Ali Yaghoubi,
Volume 15, Issue 4 (Jul-Aug 2021)
Abstract
Background and objectives: Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the centralnervous system that can be tracked through biomarkers of disease status. The present study aimed to examine effect of eight weeks of resistance training on serum levels of neurofilament light chain and tau protein in women with multiple sclerosis (MS).
Methods: The study population consisted of 24 women with MS (aged 25 to 40 years) in Bojnourd (Iran) with expanded disability status scale score of 2-5. Patients were randomly divided into two groups of resistance training (n=12) and control (n=12). The training group performed 45-60 minutes of resistance training, three sessions a week for eight weeks. The control group did not partake in sports activity. Blood samples were taken 24 hours before the first session and 48 hours after the last training session. Analysis of covariance was used to analyze data at a significance level of 0.05.
Results: The eight-week resistance training intervention significantly decreased serum level of tau protein but had no significant effect on serum level of neurofilamet light chain.
Conclusion: According to the research results, eight weeks of resistance training could have favorable effects on serum level of tau protein in MS patients.
Mobina Hosseini, Meysam Hasannejad-Bibalan, Tofigh Yaghoubi, Mohammadreza Mobayen, Parisa Khoshdoz, Sara Khoshdoz, Niloofar Faraji, Hadi Sedigh Ebrahim-Saraie,
Volume 15, Issue 6 (Special issue (Nov-Dec) 2021)
Abstract
Background and objectives: Bacterial contamination of wounds is a serious problem, particularly in burn patients. Gram-positive bacteria are the predominant cause of infection in newly hospitalized burn cases. This study aimed to survey the prevalence and antibiotic resistance pattern of gram-positive bacterial isolates among burn patients in Rasht, North of Iran.
Methods: This cross-sectional study was conducted on burn patients with a positive culture for gram-positive isolates who were hospitalized in the Velayat Burn Center in Rasht, North of Iran, during 2017-2020. The isolates were identified using standard microbiological methods. Moreover, the antibiotic resistance pattern was determined by the disk diffusion method.
Results: During the study period, 671 bacterial cultures were obtained, of which a total of 16 gram-positive isolates were taken from the patients. The frequency of coagulase-negative staphylococci (CoNS), Staphylococcus aureus, and Enterococcus spp. was 68.7%, 18.8%, and 12.5%, respectively. In addition, the highest rate of resistance in CoNS isolates was against trimethoprim/sulfamethoxazole. The highest rate of resistant among S. aureus isolates was recorded against penicillin. Moreover, Enterococcus faecalis isolates showed a high level of resistance to ampicillin, erythromycin, tetracycline, gentamicin, and ciprofloxacin. All isolates were susceptible to teicoplanin. Moreover, the frequency of methicillin-resistant S. aureus isolates was 66.7%.
Conclusion: Given the increasing prevalence of drug-resistant strains, especially in susceptible burn patients, it is imperative to analyze the bacterial etiology of nosocomial infections periodically and epidemiologically.
Dr Hadi Hadi Seddigh Ebrahim-Saraei, Dr Tofigh Yaghoubi, Dr Zeynab Fathalizadeh, Dr Masoumeh Pourmohammadi, Dr Hojat Eftekhari,
Volume 20, Issue 3 (7-2026)
Abstract
Objectives: Nosocomial infection is among the most concerning issues among hospitalized patients. The present study investigated the frequency of bacterial infections and their antibiotic resistance pattern among hospitalized patients in the dermatology ward.
Methods: This cross-sectional study was conducted on patients admitted to the dermatology ward in Razi Hospital, Rasht, Iran, between 2018 and 2022. Demographical data and clinical characteristics of the 34 patients with bacterial infections were recorded and analyzed. The bacterial isolates were collected from the skin and soft tissue, urinary tract, or bloodstream infections, and the clinical findings and outcomes of the patients were recorded.
Results: Thirty-four patients had positive results for bacterial culture. The mean age of the patients was 53.56±17.14 years, and 61.8% were female. The most frequent origin of the infection was the urinary tract. Staphylococcus epidermidis (S. epidermidis) and Klebsiella spp. were more prevalent isolates. Klebsiella spp. and Escherichia coli (E. coli) were more common in patients aged <56 years and ≥56 years, respectively, and among ≥13 days and <13 days of hospitalization, respectively. Antibiotic resistance were high in S. epidermidis and Pseudomonas aeruginosa (P. aeruginosa)isolates, where showed resistance to all antibiotics.
Conclusion: This study revealed significant patterns of bacterial infections and antibiotic resistance in dermatology ward patients with E. coli and Klebsiella spp. Predominant in urinary tract infections and a diverse profile in skin and soft tissue infections.
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