Showing 7 results for Mahmoodi
Hosseini, Ma, Baniaghil, Ss, Mahmoodi, E, Bagheri Sani, Y, Dahbashi, Gh,
Volume 9, Issue 3 (Jul,Aug2015[PERSIAN] 2015)
Abstract
Abstract
Background and Objective: The donor selection and screening of blood donors for infectious factors is the main target of blood transfusion organization. this study aimed at determining the prevalence of HCV, HBV and HIV in blood donors of Golestan province , from 2012 to 2013.
Material and Methods: This cross-sectional study was conducted on all files of blood donors with positive lab results in Golestan Blood Transfusion Services. The test results, demographic characteristics and the Prevalence of hepatitis B and C and HIV were determined . The results were analyzed by SPSS software.
Results: The blood donors were 47,830 and 45,811 in 2012 and 2013, respectively. The Prevalence of HBV in 2012 was%0. 299 and in 2013 %0. 284; of HCV % 0. 06 in 2012 and % 0.05 in 2013, and the prevalence of both HCV and HIV totally was 0. 001percent in two years of study. The highest rate of positive case was among the first time donors, married and in those with less than high school education (P<0.05).
Conclusion: Regarding the high rate of positive cases among the first-time blood donors, married and less educated, it is recommended that public media be used for giving information to control communicable infections.
Keyword: HBV; HCV; HIV; Prevalence; Blood Donors .
Haghshenas, Mr, Hosseini, E, Babamahmoodi, F, Nandoust-Kenari, Sh, Tabrizi, A,
Volume 9, Issue 3 (Jul,Aug2015[PERSIAN] 2015)
Abstract
Background and Objective: Influenza is an acute respiratory infection caused by Influenza virus with three kinds of A, B and C . This virus spreads througout the world and produce some epidemics with different intensities . This study aimed to determine the prevalence of influenza B in patients reffering to health centers.
Material and Methods: this study was conducted on 878 samples in 2011-2013. Using PureLinkTM Viral RNA/DNA Kit, Influenza-RNA was extracted. Then Influenza B was distinguished by using SuperScript III Platinum, Quantitive Real Time PCR System from InvitrogenTM , specific primers and probs.
Results: the rate of Influenza B positive was %5.58 of the patients that %55.10 of them were female and %44.89 male. The highest rate was related to 31-40 and 51-60 year old patients.
Conclusion:
given the prevalence of influenza B virus and lack of genetic changes , it is recommended that a proper vaccine for improving immunty and effective drugs for treatmet be used.
Keywords: Influenza B Virus; Respiratory Tract Infections; Common Cold; RT-PCR
Minoo Mahmoodi , Mozhgan Zeini, Siamak Shahidi,
Volume 11, Issue 4 (Jul-Aug 2017)
Abstract
ABSTRACT
Background and Objectives: Hippocampus is the main structure involved in spatial learning and memory consolidation. Formation of spatial memory can be strongly influenced by medications, hormones and different substances. Due to importance of new pharmacotherapy on drug administration in pregnancy, the aim of this study was to investigate the effect of letrozole-therapy during pregnancy on memory and learning in offspring rats.
Methods: In this study, 24 pregnant rats were divided into a control and three experimental groups (N=6). The subjects received low dose (0.25 mg/Kg), average dose (0.5 mg/Kg) and high dose (1 mg/Kg) of letrozole orally during 16-19 days of gestation. After maturating, learning and memory of the offspring were assessed by passive avoidance learning apparatus. Data were analyzed by SPSS 20 using one-way analysis of variance and the Tukey's test. P-values less than 0.05 were considered statistically significant.
Results: Weights of the offspring who received letrozole decreased significantly compared with the control. There was no significant difference in the step-through latency between the experimental groups. However, the step-through latency and time spent in the dark compartment decreased significantly in the experimental groups compared with control group (P<0.05).
Conclusion: The results of this study show that letrozole can influence learning and memory of offspring rats.
Keywords: Letrozole, Gestation, Memory, Learning, Offspring, Rats.
Reza Hakimi Alni , Abdolmajid Mohammadzadeh , Pezhman Mahmoodi , Mohammad Yousef Alikhani ,
Volume 11, Issue 6 (Nov - Dec 2017)
Abstract
ABSTRACT
Background and Objectives: Determining the genetic relationship between S. aureus isolates is important for epidemiological surveillance and control of infections caused by this bacterium. The present study was conducted to determine polymorphisms of coagulase gene (coa) among S. aureus isolates from pastry and cheese samples using restriction fragment length polymorphism (RFLP) analysis.
Methods: Overall, 65 S. aureus isolated from pastry (n=45) and cheese (n=20) samples were examined for the coa gene by polymerase chain reaction (PCR). PCR products were digested with AluI enzyme and the products were assessed using gel electrophoresis.
Results: Except for two isolates, all isolates were positive in coa-PCR and produced four different PCR products, with molecular sizes ranging from 570 to 970 bp. Overall; five distinct RFLP patterns were detected (I-V). Although pattern types I and III were present in isolates from both samples, types I and IV were mainly present in isolates from cheese and pastry samples, respectively.
Conclusion: PCR-RFLP analysis of the coa gene indicates that S. aureus isolates from pastry and cheese samples may be originated from different sources. However, as one pattern type was predominant in each group, it can be concluded that majority of the isolates may have the same origin.
Keywords: Staphylococcus aureus, PCR-RFLP, Coagulase, Pastry, Cheese.
Naficeh Sadeghi , Mohammad Reza Vafi , Behrooz Jannat , Masoomeh Behzad , Mohammad Reza Oveisi , Mannan Hajimahmoodi ,
Volume 14, Issue 2 (Mar-Apr 2020)
Abstract
Background: Tahini (sesame paste) is a kind of food obtained from sesame seeds. To our knowledge, this is the first study to measure total antioxidant activity and total phenolic compounds in tahini brands available in Iranian market.
Methods: In this study, 111 tahini samples were collected and purchased from the Iranian Market, including 37 commercial brands (three samples for per brand). The ferric reducing ability of plasma (FRAP) method was used to measure total antioxidant activity in each sample. Total phenol contents were measured by the Folin–Ciocalteau method in tahini brands.
Results: Current study showed Mino-dates brand (119.93 µmol/ml ±0.159), Trang-Chocolate brand (56.30 µmol/ml ±0.056), Barsam-coffee (45.13µmol/ml±0.094), and Chocolate-barsam brand (53.23 µmol/ml ±0.112), respectively, have more total antioxidant activity than other brands (p< 0.001). Moreover, Mino-dates brand (2057.33 µmol/ml ±0.094), barsam-coffee (805.51 µmol/ml ±0.041), Chocolate-barsam brand (807.42 µmol/ml ±0.095), and Trang-Chocolate brand (685.75 µmol/ml ±0.086), respectively, have more total phenolic compounds than other brands (p< 0.001).
Conclusion: According to the results of this study, Tahini brands with higher polyphenol contents antioxidant capacity also had higher antioxidant capacity. It can be concluded that Tahini in the Iranian market is one of the most valuable foods in terms of antioxidant activity and total phenolic contents.
Abdolrasoul Hakim Elahi, Rasoul Sharifi, Minoo Mahmoodi, Seyed Mehrdad Kassaee,
Volume 14, Issue 5 (Sep-Oct 2020)
Abstract
Background and objectives: The aim of this study was to evaluate the effectiveness of octopine (phytogenic-derivative of arginine) on antioxidant indices, trace elements and lipid profiles of a mouse model of breast cancer.
Methods: In this study, 48 Balb/c mice were divided into six groups: healthy control, cancer control, cancer group receiving 50 mg of octopine, cancer group receiving 100 mg of octopine and cancer group receiving 150 mg of octopine. The octopine treatment was carried out for three weeks. The 4T1 cell line was used to induce cancer. Fasting blood samples were taken from mice to evaluate lipid profile, copper and zinc levels. Malondialdehyde, superoxide dismutase and glutathione peroxidase activity in breast tumor tissues was evaluated. Data were analyzed by SPSS 18 software using one-way ANOVA and t-test.
Results: Octopine had no significant effect on superoxide dismutase and glutathione peroxidase activity in the treatment group compared with the control cancer group. However, it significantly increased total antioxidant capacity and decreased malondialdehyde activities. Furthermore, treatment with octopine significantly decreased serum zinc, copper, TG, cholesterol and low-density lipoprotein levels but significantly increased high-density lipoprotein compared with the untreated cancer group.
Conclusion: Octopine administration is effective in reducing some oxidative stress indices and improving trace elements abnormalities and lipid profile in mouse models of breast cancer.
Behnoush Khasheii, Pezhman Mahmoodi, Abdolmajid Mohammadzadeh,
Volume 15, Issue 5 (Sep-Oct 2021)
Abstract
Increasing antibiotic resistance is a global health problem. In recent years, due to the indiscriminate use of antibacterial compounds, many bacterial pathogens, including staphylococci, members of the
Enterobacteriaceae family including
Klebsiella pneumoniae and bacteria such as
Pseudomonas aeruginosa and
Acinetobacter baumannii have become multi-drug resistant. Consequently, it is important to explore alternative approaches for eliminating resistant strains. Bacteria synthesize low-weight molecules called siderophores to chelate iron from the environment as a vital element for their growth and survival. One way to deal with resistant bacterial strains is to utilize siderophore-mediated iron uptake pathways as entrance routes for drug delivery. Therefore, the production of drugs with Trojan horse strategy in the form of conjugated siderophore-antibiotic complexes has recently received much attention
for dealing with resistant isolates.
In this review, we discuss the efficacy of siderophore-antibiotic conjugates as a Trojan horse strategy for eliminating drug-resistant pathogens.
