Showing 3 results for Mahjoub
Ms Shirakdehi, M Rezaei, E Nadi, H Mahjoub, Mt Goodarzi,
Volume 8, Issue 1 (spring[PERSIAN] 2014)
Abstract
Abstract
Background and Objective: Oxidant-antioxidant imbalance plays a key role in pathogenesis of chronic obstructive pulmonary disease (COPD). This study aimed to evaluate homocystiene and total antioxidant capacity in COPD patients, compared to smoker and non-smoker healthy people.
Material and Methods: We measured total antioxidant capacity with Cayman Kit, uric acid with Pars Azmoon kit٫ homocysteine with ELISA Kit and inflammatory cells (leukocytes) in 29 COPD patients, 29 smokers and 29 non-smokers.
Results: Uric acid was significantly higher in COPD patients compared to healthy smokers and healthy non-smokers (p<0.05). Total antioxidant capacity was significantly lower in COPD patients compared to healthy, non smokers (p=0. 003). In COPD patients, homocysteine and leukocytes levels were significantly higher than those in healthy smokers (P<0.05) and healthy non- smokers (p<0.001).
Conclusion: According to high inflammatory cells and low antioxidant capacity in COPD, early administration of appropriate medication is recommended to reduce systemic and topical inflammation. Reduction in the exposure to oxidizing compounds can slow the process of degradation and damage to lungs.
Keywords: Chronic Obstructive Pulmonary Disease Homocysteine Oxidative Stress
Zahra Kiani, Pouria Mohammad Parast Tabas, Khashayar Khalilpour, Mahjoube Goldani Moghadam, Majid Zare_bidaki,
Volume 15, Issue 5 (Sep-Oct 2021)
Abstract
Background and objectives: Medicinal plants have long been considered as one of the most important pillars of traditional medicine. Existing challenges in the treatment of diseases, particularly infectious diseases, are major drivers for herbal medicine studies. Tribulus terrestris has been widely used in traditional medicine to treat various diseases. This study aimed to investigate in vitro antibacterial effect of the aqueous extract of T. terrestris on several oral bacteria.
Methods: In this experimental study, after preparing the aqueous extract of T. terrestris, minimum inhibitory and bactericidal concentrations (MIC and MBC) of the extract were determined against standard strains of Streptococcus mutans, Staphylococcus aureus, Klebsiella pneumoniae and Streptococcus pyogenes using the broth microdilution method. The experiments were repeated three times and the results were analyzed with SPSS 22 using the one-way analysis of variance (ANOVA) and LSD statistical tests with the significance level set at 0.05.
Results: The aqueous extract of T. terrestris had the highest inhibitory effect on S. pyogenes and S. mutans, and the difference between the MIC and MBC values was significant (P <0.05). However, no such effect was observed against S. aureus and K. pneumonia at concentrations below 50 mg/ml when compared to ampicillin and chlorhexidine.
Conclusion: The aqueous extract of T. terrestris has significant antibacterial effects against S. pyogenes and S. mutans. Therefore, it can be incorporated into topical formulations such as toothpaste and mouthwash products after further in vivo and toxicity experiments.
Aya Chakroun, Hela Baccouche, Sonia Mahjoub, Neila Ben Romdhane,
Volume 15, Issue 6 (Special issue (Nov-Dec) 2021)
Abstract
Background and objectives: Differential diagnosis between clonal lymphocytosis (CL) and reactive lymphocytosis (RL) is often established through blood smear examination but with some limitations. We aimed to evaluate ability of clinical data and extended-cells blood count (CBC) parameters to discriminate CL from RL and to establish a decision-making algorithm for moderate lymphocytosis in adults.
Methods: A total of 85 samples were collected from adults with absolute lymphocytescount of >5G/l. The samples were divided into RL group (n=34) and newly diagnosed CL group (n=51).Demographic data, CBC parameters including high fluorescence lymphocytes cells percentage (HFLC%) and abnormal lymphocytes or blasts (’AbnLym/BL’’) morphological flag were evaluated for each study group. New threshold for discriminating parameters were determined using receiver operating characteristic (ROC) curves and used in an algorithm for moderate lymphocytosis.
Results: Age, high lymphocytes count and the presence of the ’AbnLym/BL’’ flag and low HFLC% were predictor of malignant lymphocytosis. Age threshold of 62.5 years and absolute lymphocytes count of > 10.47 G/l were highly effective in CL detection with area under the ROC curve of 0.9 and 0.99, respectively. In addition, HFLC% showed an area under the ROC curve of 0.71. Considering ALC threshold of 10.47 G/l alone, a sensitivity of 96.7% and a specificity of 100 % were achieved. For moderate lymphocytosis ranging between 5 and 10.47G/l, no false positive or negative result was detected when we considered both the proposed ALC and age cut-offs.
Conclusion: A combination threshold for ALC and age appears to be helpful for screening CL, especially in moderate lymphocytosis for both laboratory and clinical routine practice.
