Showing 4 results for Rana
Faranak Balaghi Inaloo, Roya Askari, Amir Hossein Haghighi, Kaveh Kashani, Paul Friedemann,
Volume 17, Issue 3 (May-Jun 2023)
Abstract
Background and objectives: Studies have reported contradictory results regarding the relationship between serum neurofilament light chain (NFL) and fatigue severity. The aim of our study was to investigate serum NFL and fatigue severity in patients with multiple sclerosis (MS) after home-based and outdoor Pilates training.
Methods: The study population consisted of 44 women with MS (aged 25 to 40 years) with an expanded disability status scale score of 2-5. The patients were randomly divided into three groups: home-based training (HPT, n=15), outdoor training (OPT, n=15), and a control group (n=14). The training groups performed Pilates exercises for 8 weeks individually at home and under the sun. Blood samples and completed Fatigue Severity Scale forms were taken 48 hours before the first session and after the 8-week intervention.
Results: The results showed that OPT caused a more notable increase in serum vitamin D (32.76±5.13, p<0.001) and a decrease in NFL (15.98±2.26, p <0.001) and FSS score (2.51±0.35, p<0.001) compared with HPT. Also, HPT lowered NFL (18.01±2.28, p<0.001) and FSS score (3.84±0.98, p<0.001) compared with the control group.
Conclusion: Pilates training can reduce NFL levels and FSS scores in women with MS. In addition, OPT is more effective than HPT in reducing NFL and FSS and increasing vitamin D levels.
Misha Antani, Anjali Goyal, Jalashree Rana,
Volume 18, Issue 1 (Jan-Feb 2024)
Abstract
Background: A higher occurrence of raised homocysteine levels has been reported in individuals with type 2 diabetes (T2D), particularly those with macroangiopathy and nephropathy. Given that hyperhomocysteinemia is a risk factor for T2D, mitigating this condition could potentially benefit T2D patients. This study aimed to investigate the influence of homocysteine on T2D and cardiovascular disease (CVD), as well as the factors that modify homocysteine levels.
Methods: This cross sectional, observational study was conducted on 122 individuals in a tertiary care center in Western India. Data related to anthropometry, demography, and biochemistry were gathered following established standards. Statistical analysis was performed using Chi-square test. A P-value of <0.05 was considered statistically significant.
Results: The findings indicated a significantly larger percentage of hyperhomocysteinemia in males, smokers, and individuals with elevated fasting blood sugar and HbA1c levels. The proportion of subjects with high homocysteine levels was notably greater in those with high total cholesterol and triglyceride levels. A significant correlation was observed between increased serum homocysteine levels and decreased serum folic acid and vitamin B12 levels in patients with ischemic heart disease.
Conclusion: Elevated homocysteine levels are observed in smokers and diabetic patients, potentially leading to CVD. Furthermore, this study found a correlation between an increase in serum homocysteine levels and a decrease in serum folic acid and vitamin B12 levels in patients with ischemic heart disease.
Darshana Kottahachchi, Tharushika Deshani Hewapathirana, Thisali Chandula Perera, Shashikala Suresh,
Volume 18, Issue 2 (Mar-Apr 2024)
Abstract
Multiple myeloma (MM) is a plasma cell neoplasm that is characterized by the clonal proliferation of malignant plasma cells in the bone marrow. It is considered the second most common hematological malignancy which accounts for approximately 1% - 2% of all cancers and among 10% of hematological malignancies. Autologous peripheral blood stem cell Transplantation (PBSCT) is the best treatment for MM. Since the optimum harvested stem cell yield is a crucial factor for sufficient engraftment, the enumeration of Mononuclear cell (MNC) count in peripheral blood and harvested CD 34+ stem cell count can be considered as the best predictive markers for the best timing of apheresis which positively correlates with engraftment outcome of PBSCT.
MNC count can be obtained using either a hematological analyzer or peripheral blood smear while flow cytometry is the advanced technology that can be used to enumerate CD 34+ stem cell count other than peripheral blood smear. The unavailability of a flow cytometer, the expensiveness of this method, and the lack of trained personnel regarding this new technology, especially in lower-middle-income countries cause disturbance in the enumeration of stem cells. In such a situation, this review describes the importance of establishing an association between peripheral blood MNCs and harvested CD 34+ cells. Furthermore, this association facilitates conducting effective PBSCT for MM patients even in the absence of a flow cytometer and eventually, it focuses on decentralizing the treatment of PBSCT.
Zahra Ahmadnia , Samane Rouhi, Hamed Mehdinezhad , Siamak Sabaghi , Alireza Firouzjahi , Mohammad Ranaei , Hossein Ghorbani , Maryam Pourtaghi, Mana Baziboron ,
Volume 18, Issue 4 (Jul-Aug 2024)
Abstract
Pasteurella species are one of the most common pathogenic bacteria in domestic animals, and they are seen more in people with weak immune systems. This research aims to investigate a case of a patient with multiple sclerosis from whose sputum Pasteurella multocida (P. multocida) was isolated. The patient was a 28-year-old man with multiple sclerosis who had persistent coughs due to food being stuck in his throat. The patient was a 28-year-old man with multiple sclerosis who had persistent coughs due to food being stuck in his throat. The primary diagnosis was pneumonia hydropneumothorax and complete collapse of the left lung. The patient's sputum culture after the first visit to the hospital was positive for P. multocida, which was not found in a second culture. In the subsequent cultures of the patient, Acinetobacter, Klebsiella, Pseudomonas aeruginosa (P. aeruginosa), and Citrobacter were found, which had extensive drug resistance to all antibiotics. In the secondary computerized tomography (CT) scan, mild pleural effusion on the left side, pneumothorax, and complete collapse with bronchiectasis was seen. Despite the treatments, the patient finally died of cardiac arrest and bradycardia. Infection with P. multocida was found in a patient with multiple sclerosis. Also, hospital-acquired infections with drug resistance caused by the weakness of the patient's system appeared in the patient who was hospitalized in the intensive care unit (ICU), and finally, the patient died. According to antibiotic patterns, the best antibiotic to which the bacteria is sensitive can be considered the primary treatment to avoid irrational antibiotic prescriptions.
