Showing 4 results for Patel
Usha Patel, Nanda Jagrit, Shubham Panchal, Ankita Kacha, Rujuta Ravat,
Volume 16, Issue 4 (Jul-Aug 2022)
Abstract
Background and objectives: Lesions of the head and neck region are routinely encountered by clinicians, in patients across all age groups. Diagnoses range from reactive inflammatory conditions to malignancies. Cancer is among the leading causes of death in India. Head and neck cancers account for 23% of all cancer incidents in males and 6% of all incidents in females in India,. Fine needle aspiration cytology (FNAC) of cervical masses is an easy, effective, and relatively inexpensive technique. The aim of this study was to determine occurrence of various head and neck swellings and classify them under various categories.
Methods: The present study included 100 cases of palpable cervical swellings who had been referred to the AMC MET Medical College, Ahmedabad (India) from June 2018 to October 2020.
Results: The majority of cases were lymph node swellings (57%), followed by thyroid swellings (23%), salivary gland swellings (12%), and soft tissue swellings (8%). Among all cervical region swellings, tuberculous lymphadenitis and thyroid lesions were the most prevalent.
Conclusion: The findings suggest that lymph node swellings are most commonly observed in the cervical area, and that the majority of them are inflammatory, requiring medical treatment rather than surgery. Moreover, FNAC is a straightforward, quick, and cost-effective way to distinguish between non-neoplastic and metastatic malignant lesions, which could help timely surgical interventions.
Usha Patel, Nanda Jagrit, Toral Bhavsar, Shubham Panchal, Krutina Parikh, Himanshu Nayak,
Volume 17, Issue 3 (May-Jun 2023)
Abstract
Background and objectives: Mucormycosis is a complication in post-coronavirus disease 2019 (COVID-19) patients in India. This study was done to evaluate the prognostic value of clinical, histopathologic findings, microbiological features, and biochemical parameters such as D-dimer, lactate dehydrogenase, and serum ferritin in post- COVID-19-patients with rhino-orbital mucormycosis.
Methods: This retrospective observational study was carried out on biopsies taken from 50 post-COVID-19 patients suspected of mucormycosis. The biopsy specimens were processed and stained with hematoxylin and eosin, periodic acid–schiff, and Wright-Giemsa. In addition, 10–20% potassium hydroxide wet mount and culture on sabouraud dextrose agar were performed to detect Mucor. The biochemical parameters were measured using ARCHITECT ci8200 chemistry analyzer.
Results: Overall, 30 cases (60%) were positive for fungal elements, and growth of Mucor spp. was found in 28 cases (56%). In histopathology, 70% of cases (n=35) showed broad, aseptate, ribbon-like hyphae with wide-angled branching diagnostic of mucormycosis. There seemed to be a site-wise overlap between the nasal/maxillary sinus and rhino-orbital/rhino-cerebral variety. There was no difference between the patients in terms of gender. The most common risk factor was diabetes mellitus (observed in 80% of cases). In patients with invasive mucormycosis, inflammatory biomarkers such as serum ferritin, serum lactate dehydrogenase, C-reactive protein, and D-dimer were greater than the normal range, whereas procalcitonin was within the reference range.
Conclusion: It can be concluded that raised metabolic markers, direct 10% KOH examination and histological features including angioinvasion as well as rhino-orbital and cerebral extension might assist doctors in diagnosis, progression, and survival rate.
Deep Rajendrabhai Kothari, Nilesh Dutt, Palak Prajapati, Pankaj Garg, Mamta Patel,
Volume 18, Issue 3 (May-Jun 2024)
Abstract
Background: The sputum smear-negative pulmonary tuberculosis (PTB) is a diagnostic challenge for physicians. It has been shown that adenosine deaminase (ADA) activity increases in various body fluids of patients with tuberculosis (TB). A prospective clinical trial was conducted to determine the effectiveness of ADA activity in bronchoalveolar lavage (BAL) in subjects who have sputum smear-negative PTB.
Methods: A total of 29 patients (M/F: 15/14), mean age (36.8 years), were enrolled in our study from October 2021 to August 2022 after providing written consent. The mean duration of symptoms was 41.66 days. Out of 29 patients, 21 patients had BAL ADA 4.81±1.68 unit??, for whom AKT treatment was started and cured, while four patients with BAL ADA 4.50±2.86 unit? did not improve, and four patients with BAL ADA 6.52±1.16 whose AKT treatment is ongoing at present but clinically improved. The sensitivity of BAL ADA with the outcome of 29 patients is 75%, while for BAL CBNAAT, it is 80%. When we apply a formula for combined sensitivity for the parallel test, then it comes to 95%, which indicates a great number of patients gets the benefit when we apply both tests simultaneously.
Results: We conclude that ADA activity was significantly increased in BAL.
Conclusion: BAL ADA is a useful and effective investigation for the diagnosis of PTB.
Tejas Contractor, Himali Thakkar, Anupama Dayal, Sandesh Agrawal, Hani Patel,
Volume 18, Issue 6 (4-2025)
Abstract
Background And Objectives: Upper gastrointestinal (GI) lesions are significant contributors to morbidity, with endoscopy serving as a crucial minimally invasive tool for their visualization and biopsy. This study explores the demographic patterns of upper GI lesions by age, sex, and biopsy site, comparing the prevalence of neoplastic and non-neoplastic lesions across the esophagus, stomach, and duodenum, while underscoring the importance of early detection and management.
Method: This cross sectional retrospective study conducted at a tertiary care center in Gujarat, India, July2019 to October 2021. A total of 104 upper GIT biopsies were included and were categorized based on age, sex, site, endoscopic findings and histomorphology. Histopathological analysis involved routine processing, staining and microscopic examination by histopathologist.
Result: Out of 104 endoscopic biopsies, the majority were from the 46-55 age group, followed by 66-75, with a male to female ratio of 1.7:1. Oesophageal biopsies were most common (48%). Non-neoplastic lesions (52.8%) were predominant, with duodenitis (48%) and celiac disease (33.3%) most frequent. Neoplastic lesions (47.1%) were prevalent in the esophagus (36.5%), primarily squamous cell carcinoma. Gastric biopsies showed benign lesions like gastritis more than malignant, with adenocarcinoma most common. Endoscopic findings included thickening, scalloping, nodularity, polyps, or fragile growths, emphasizing the diversity of upper GIT lesions and the need for early detection and treatment.
Conclusion: The study emphasizes biopsies' crucial role in promptly diagnosing esophageal malignancies and identifying premalignant conditions like Barrett's esophagus for timely intervention. It reaffirms the pivotal role of endoscopic biopsy in clinical management, stressing the necessity of a multidisciplinary approach.
