Sh Hezarkhani, F Nik Nejad, N Shahini,
Volume 8, Issue 3 (Autumn[PERSIAN] 2014)
Abstract
Abstract
Background and Objective: Onychomycosis is a fungal nail infection causing ulcers, diabetic foot and enhance nail infection. This study was designed to evaluate the prevalence of onychomycosis in type II diabetes.
Material and methods: This descriptive-analytic study was conducted on 300 diabetic patients selected randomly among those referred to Panje Azar endocrinology clinic. They were examined for peripheral vascular disease, Skin lesions, diabetic foot and Peripheral neuropathy. The Laboratory tests such as FBS, HbA1c, Direct smear and fungal culture were used.
Results: The patients with onychomycosis were 19 (6.3%) their mean age was 53.65±1.04 the youngest was 28 and the oldest 84. The male to female infection ratio was of 1.08 that was not statistically significant. There was no significant difference in regards to ethnicity, age, BMI, FBS, HbA1C. The location of the infection was 16 on feet (29.6%), and three on both hands and feet (P = 0.000)
Conclusion: The prevalence of fungal infection was less frequent than that of other studies. Given that there was no significant relationship between different demographic data and its prevalence, further studies with larger sample size are needed.
Keywords: Prevalence, Fungal Infections, Diabetes
Sharabeh Hezarkhani , Khosro Ghojoghi , Sara Hosseinzadeh , Naser Behnampour , Farshid Fathabadi , Zahra Hesari , Hamid Reza Joshaghani ,
Volume 18, Issue 6 (Nov-Dec 2024)
Abstract
Background: Leptin and adiponectin, two members of the adipokine family, play roles in increasing lipid metabolism and inhibiting lipogenesis. Reduced levels of these cytokines are associated with obesity and insulin resistance. This study aimed to determine the serum levels of leptin and adiponectin in type-2 diabetic patients with and without metabolic syndrome compared to a control group.
Methods: Three groups of individuals participated in this study: 47 type-2 diabetic patients with metabolic syndrome (DM+MetS), 25 type-2 diabetic patients without metabolic syndrome (DM-MetS), and 40 individuals with no history of diabetes or metabolic syndrome (Control group). Fasting blood samples were collected, and serum levels of fasting blood sugar, cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol were measured using the enzymatic method. Blood pressure, height, and weight were recorded using stadiometers, while leptin and adiponectin levels were determined via enzyme-linked immunosorbent assay.
Results: A significant difference was observed between the DM+MetS group and the DM-MetS group in serum leptin (p = 0.004) and adiponectin (p < 0.001) levels. In patients with type-2 diabetes and metabolic syndrome, serum leptin (p = 0.530) and adiponectin (p < 0.001) levels were lower compared to the control group.
Conclusion: A decrease in the serum levels of key adipokines, such as leptin and adiponectin, in type-2 diabetic patients may serve as a predictor of metabolic syndrome.
