Search published articles


Showing 3 results for Firoozeh
Synthesis of New Schiff Base Ligand and Its Complexes in The Presence of Some Transition Metal Ion and Evaluation of Their Antibacterial Properties
Taiebeh Tamoradi, Hamid Goudarziafshar , Somayeh Rashki , Fatemeh Katouzian, Firoozeh Chalabian,
Volume 11, Issue 2 (Mar-Apr 2017)
Abstract
ABSTRACT
        Background and objectives: Synthesis and characterization of several metal complexes (metal ions: Co2+, Ti4+ and Ce3+) of macroacyclic Schiff base ligand have been reported. The Schiff base ligand is prepared from the condensation reaction of 1, 4-di-(4-fluoro-2-aminophenoxy) butane with salicylaldehyde in ethanol. In addition, antibacterial activity of metal ions, Schiff base ligand and their complexes have been investigated. Recent studies show that many Schiff base complexes have antibacterial activity against Gram-positive and Gram-negative bacteria. Therefore, we aimed to synthesize new Schiff base complexes and evaluate their antibacterial activity against a number of Gram-positive and Gram-negative bacteria.
         Methods: Schiff base ligand and their complexes were characterized by mass spectrometry and IR, H-NMR and C-NMR spectroscopy. The in vitro antibacterial activity of the Schiff base ligand, metal ions and their complexes were evaluated against some Gram-positive and Gram-negative bacteria by disk diffusion method and determining minimum inhibitory concentration.
          Results: In this study, the Schiff base complexes had good antibacterial activity, but the Schiff base ligand and metal ions did not show any antibacterial effect. In some cases, the antibacterial effect of the complexes was higher than that of the standard antibiotics tetracycline and gentamycin. The titanium complex showed the highest antibacterial activity in both methods. This complex created the largest growth inhibition zone (diameter: 100mm) against Staphylococcus aureus, and had the lowest minimum inhibitory concentration against Bacillus subtilis (6.75 mg/ml).
          Conclusion: The compounds synthesized in our study have strong antibacterial activity.
          Keywords: Schiff base complex, Schiff base ligand, antibacterial activity, Staphylococcus aureus, Bacillus subtilis.

Combined Effects of Regular Aerobic Exercise with Vitamin D Supplementation on Some Apoptosis Indices in the Lung of Rats Exposed to Hydrogen Peroxide
Somayeh Ramezani, Maghsoud Peeri, Mohammad Ali Azarbaijani, Firoozeh Dehghan,
Volume 13, Issue 5 (Sep-Oct 2019)
Abstract

ABSTRACT
Background and Objectives: Exercise is a strong physiological stimulus that can affect apoptosis in the lungs by altering a number of extracellular and intracellular signaling pathways. The present study examined effects of regular aerobic exercise and vitamin D on expression of Bcl-2, Bax and caspase-3 in lung tissues of male rats exposed to hydrogen peroxide.
Methods: Forty-eight adult male Wistar rats were randomly assigned into six groups of eight, including 2 x H 2 O 2, 2H 2 O 2, Vit D (2HD), 2H2O2 + Regular Exercise Training (2HE), 2H2O2 + D3 + E (2HDE) ; Dimethyl sulfoxide (DMSO) and control (C). Subjects in the training groups performed aerobic exercise for eight weeks. Bax, Bcl-2, caspase-3 expression in the lung tissues was measured using RT-PCR.
Results: Bcl-2 expression in the exercise (P = 0.004) and vitamin D (P = 0.006) groups increased significantly compared to the control groups. Bax, Bcl-2 and caspase-3 expression was significantly lower in the exercise group and vitamin D supplementation group compared to the control group. On the other hand, concurrent exercise and vitamin D significantly reduce Bax expression but had no significant effect on Bcl-2 and caspase-3 expression.
Conclusion: Our results demonstrate that regular aerobic exercise along with vitamin D supplementation may play a role in reducing apoptosis in lungs following severe oxidative stress.
Keywords: Apoptosis, Bcl-2, Bax, Caspase3, Aerobic Exercise, Vitamin D
 
 


An Update on the Prevalence of Nontuberculous Mycobacteria in Clinical Samples in Iran during 2000-2022: A Systematic Review and Meta-Analysis
Fahimeh Firoozeh, Arezoo Firoozeh, Abbas Salmani,
Volume 17, Issue 3 (May-Jun 2023)
Abstract
Background and objectives: Nontuberculous mycobacteria (NTM) are isolated from domestic and animal products as well as man-made systems such as medical devices, drinking water systems, water tanks, and shower streams.  This study aimed to investigate the prevalence of NTM in clinical samples in Iran during 2000-2022.
Methods: Published studies addressing the prevalence of NTM in clinical samples in Iran were reviewed according to the Preferred Reporting Items for Meta-Analyses and Systematic Reviews protocol.  Original articles in Persian and English published between January 2000 and 2022 in databases such as Scopus, PubMed, Web of Science, Google Scholar, and Iranian databases were included. The prevalence of NTM at 95% confidence interval (CI) was calculated by comprehensive meta-analysis.
Results: Overall, 26 studies were included in the review. The combined prevalence of NTM in positive mycobacterial cultures was 4.5% (95% Cl: 3.1-6.5). Mycobacterium simiae [35.8% (95% CI 16.4-44.4)], Mycobacterium intracellulare [19% (95% CI 8.7-28.3)], and Mycobacterium kansasii [13.4% (95% CI 7.3-24.3)] were the most common slowly growing species, while Mycobacterium fortuitum [24.6% (95% CI 12.9-46.7)], Mycobacterium terrae [18.5 % (95% CI 11.5-29.2)], and Mycobacterium gastri [15.9% (95% CI6.0-41.2)] were the most prevalent rapidly growing mycobacteria. 
Conclusion:  In summary, our findings indicate a relatively high combined prevalence of NTM in clinical samples in Iran.  Some of these species such as M. simiae can have clinical and radiologic manifestations similar to those of TB and are resistant to anti-TB drugs. Therefore, standardizing the use of molecular methods for the detection of NTM seems necessary.


  


				

				

				







			

			

				

				  
 Page 1 from 1
					     
				  

				

			

			


		




















  

       

      
 © 2007 All Rights Reserved | Medical Laboratory Journal

    


  





            
            
 Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.