Search published articles


Showing 3 results for Bazzazi
Seroepidemiology of Helicobacter Pylori infection in Patients With Coronary Syndrome in Gorgan
H Bazzazi, M.a. Ramezani, M Bazoori, A Mohamadi Bondarkheili, M Arabahmadi, A Ghaemi,
Volume 1, Issue 1 (Spring - Summer 2007 [PERSIAN] 2007)
Abstract

Abstract

Background and objectives:

most common causes of morbidity and mortality in industrial and

developing countries. Recent studies have suggested that

A coronary heart disease is one of the

Helicobacter pylori

heart disease therefore, this study was carried out in Gorgan, Iran, to

show the relationship between coronary disease and Helicobacter

pylori infection.

caused infection may be associated with chronic

Materials and Methods:

carried out on 109 patients suffering from acute coronary syndrome

and 85 healthy individuals, ELISA was used to determine Anti

Helicobacter pylori Anti bodies (IgA, IgG ).

In this cross sectional case-control study

Results:

while in control group were %32.9 and %62.4. There was significant

difference between IgA of two groups (p<0.007). Simultaneous

presence of both IgG and IgA in patients affected by Coronary disease

was meaningful (p<0.003).

IgA and IgG antibodies of case group were %51.4 and %53.2

Conclusion

be related to coronary disease, we suggest their investigation in

suspected individuals.

: Since Simultaneous presence of both IgG and IgA may

Key word

Antibody

: Acute Coronary syndrome, Helicobacter Pylori,
The Anti-β2GP1 Autoantibody Level in Serum of Pregnant Women with History of Recurrent Miscarriage
Bazzazi, H., Govahi, M., Jahazi, A., Alizadeh, Sh., Naeimi Tabiee, E, Mokaram, R., Davarpanah, M R,
Volume 6, Issue 2 (Autumn- Winter [PERSIAN] 2012)
Abstract
Abstract Background and objectives: Recurrent miscarriage (RM) is one of the most common reproductive disorders, generally considered to be the loss of three or more pregnancies before viability. One of the causes of this disorder is the immunological factors such as autoantibodies associated with anti-phospholipid syndrome. Material and Methods: this case-control study was conducted on 80 pregnant women divided into two equal groups of healthy and RM women in Gorgan. The subjects were asked to fill out a questionnaire and examined by a gynecologist to distinguish their condition, healthy or RM. The blood samples were kept at -20c and assessed by both ELISA 96 and automated ELISA processor with single dose ready-to-use test to measure β2GP1 autoantibodies of IgM and IgG. Results: the results indicate that % 7.5 of RM patients are seropositive for Anti-β2GP1 IgG, and % 5 for Anti-β2GP1 IgM , but in healthy pregnants , % 7.5 are seropositive for Anti-β2GP IgG , and %7.5 for Anti-β2GP1 IgM. Family history of abortion in RM group (33.5%) is significantly higher than healthy one (17.5%). Conclusion: based on the results, the difference between the level of Anti-β2GP1 IgM and Anti-β2GP IgG in case and control groups is not significant, but the production of this autoantibody is associated with pregnancy. Key words: Autoantibody, Antiphospholipid syndrome, Recurrent Miscarriage
Frequency of Th9 Cells in Different Stages of Rheumatoid Arthritis
Hadi Bazzazi, Yaghoub Yazdani, Nasser Behnampour, Hadi Hossein-Nataj, Ali Memarian, Mehrdad Aghaei,
Volume 13, Issue 6 (Nov-Dec 2019)
Abstract
ABSTRACT
            Background and Objectives: T helper (Th) lymphocytes play a key role in the pathogenesis of autoimmune diseases. As a new subset of lymphocytes, Th9 is thought to be involved in a wide range of disorders including rheumatoid arthritis (RA). In this study, we evaluated frequency of Th9 and Th2 cells and its correlation with disease activity in patients with different stages of RA.
            Methods: The frequency of circulating interleukin 9- and/or interleukin 4-producing CD3+CD8-T cells was determined among 41 patients with established RA, 14 patients with very early RA (VERA) and 23 healthy controls by flow cytometry analysis. Then, correlation of cell frequencies with disease activity score 28 (DAS-28) was assessed. Serum levels of interleukin 6 and anti-citrullinated peptide antibodies were measured by enzyme-linked immunosorbent assay.
            Results: Frequency of Th9 cells was significantly higher in RA patients compared to healthy controls (P=0.009). Moreover, mean percentage of circulating Th9 cells in patients with inactive VERA was significantly higher than that in those with active disease (P=0.046). In addition, mean percentage of Th9 cells had a negative correlation with the DAS-28 (r=-0.568, P<0.05). There was no significant correlation between the mean serum level of interleukin 6 and percentage of Th2 and Th9 cells (P>0.05).
            Conclusion: Our results suggest that Th9 cells may have a potential role in RA initiation. Thus, targeting Th9 cells could be a promising strategy for advanced RA therapies.
            Keywords:  Rheumatoid arthritis, Th2 cells, Th9 cells.

Page 1 from 1     

© 2007 All Rights Reserved | Medical Laboratory Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.