Showing 7 results for Bazoori
H Bazzazi, M.a. Ramezani, M Bazoori, A Mohamadi Bondarkheili, M Arabahmadi, A Ghaemi,
Volume 1, Issue 1 (Spring - Summer 2007 [PERSIAN] 2007)
Abstract
Abstract
Background and objectives:
most common causes of morbidity and mortality in industrial and
developing countries. Recent studies have suggested that
A coronary heart disease is one of the
Helicobacter pylori
heart disease therefore, this study was carried out in Gorgan, Iran, to
show the relationship between coronary disease and Helicobacter
pylori infection.
caused infection may be associated with chronic
Materials and Methods:
carried out on 109 patients suffering from acute coronary syndrome
and 85 healthy individuals, ELISA was used to determine Anti
Helicobacter pylori Anti bodies (IgA, IgG ).
In this cross sectional case-control study
Results:
while in control group were %32.9 and %62.4. There was significant
difference between IgA of two groups (p<0.007). Simultaneous
presence of both IgG and IgA in patients affected by Coronary disease
was meaningful (p<0.003).
IgA and IgG antibodies of case group were %51.4 and %53.2
Conclusion
be related to coronary disease, we suggest their investigation in
suspected individuals.
: Since Simultaneous presence of both IgG and IgA may
Key word
Antibody
: Acute Coronary syndrome, Helicobacter Pylori,
A Moradi, A Abbasi, Ar Mansourian, A Ahmadi, A Sarikhani, M Bazoori,
Volume 1, Issue 2 (Autumn – Winter 2008[PERSIAN] 2007)
Abstract
Abstract: Introduction: Influenza is highly transmitted disease and vaccination is the most effective way to prevent influenza. This research was designed to study the variation of serum antibody level among the subjects had already been vaccinated against influenza. Materials and Methods: This research is a descriptive-analytical study, which was carried out on 196 subjects who had influenza vaccination (influvac 2005/2006) and 200 subjects matched by the vaccinated subjects, by age. The subject's serums were prepared seven weeks after influenza vaccination, and the control group's serums were also prepared. The serum antibody level was determined by haemaglutination inhibition test. Results: The mean age of case group is 52.2±11 and control group 48.64±5.17.The antibody titre of 115 of Vaccinated group and 15 of control is less than 40 1 The mean antibody titer of vaccinated subjects and control group is 143.4 ± 10.89 and 18.34± 3.2, respectively. The difference is statistically significant (P value=0.000). Conclusion: The findings show that the mean titer of antibody in vaccinated and control group is statistically different. It means that the influenza vaccine had a good efficacy. Key words: Vaccination, Influenza, Gorgan.
Kh Kalavi, A Moradi, Ar Ahmadi, Aj Sarikhani, M Bazoori, Mr Kyaee,
Volume 2, Issue 1 (Spring - Summer 2008[PERSIAN] 2008)
Abstract
Abstract Background and objectives: Human T-Lymphocyte Virus-1 (HTLV- 1) is known as the etiologic factor of acute T-Lymphocytic Leukemia (ATL) and tropical spastic paralysis. (TSP). Endemic factors causing infection with Human T Lymphocyte Virus-1 (HTLV-1) is based on environmental, socio-economical and health behaviors of the individuals. This virus is well distributed in families with involved members. Golestan province is located in North West part of Northern Khorasan province that had already been known as an endemic area for HTLV-1. This virus is also known as the main etiologic factor for cancers and ATL, therefore we studied the prevalence of HTLV-1 seroepidemiology in Golestan province. Material and Methods: The subjects selected by cluster sampling were 2034 healthy cases residing in different parts of Golestan province. ELISA method using Dia- pro anti HTLV-1 antibody kits was applied for serological assessment. Western Blot (HTLV BLOT 2.4) was used for confirmation purposes. Results: The subjects aged 38.66±16.54 were 2034 healthy persons. Forty-one point seven of these cases were males and the rest females. Based on ELISA method there were15 HTLV-1 positive cases (0.7%). -1. (0.7%) Six out of 15 were confirmed by western blot method (95%, CI: 0.06-0.53%). The highest prevalence sigllificant) aiology is in the highat rate in 31-40 year old gro0.7%). onclusion: This study shows that HTLV-1 is prevalent in Golestan the same as the other parts of the world. There fere: we urse on performing screening test (HTLV-) on donated blood components before delivering (OK labeling). Key words: HTLV-1, Seroepidemiology, ELISA, Western Blot, Golestan ATL(Acute T lymphocytic Leukemia) Six cases out of 15 were confirmed by western blot method (95%, CI: 0.06-0.53%). The highest prevalence was 2.6% seen in Kalaleh city (east part of the province) [95%, Cl: 0.06-0.53%). There was significant difference between the prevalence of HTLV-1 and the dwelling place. (p=002). HTLV-1 seroepidemiology was in the highest rate in 31-40 year old group (0.7%). Conclusion: This study shows that HTLV-1 is prevalent in Golestan province, the same as the other parts of the world. Therefore, we recommend performing screening test (HTLV-) on donated blood components before delivering (OK labeling). Key words: HTLV-1, Seroepidemiology, ELISA, Western Blot, Golestan province, ATL (Acute T lymphocytic Leukemia)
S Zhand, A Tabaraei, A Moradi, F Fotoohi, N Javid, M Bazoori, E Haji Mohammadi, A Ghaemi,
Volume 8, Issue 2 (summer 2014[PERSIAN] 2014)
Abstract
Abstract
Background and Objective: The emergence of a novel H1N1influenza A virus of animal origin with transmissibility from human to human poses pandemic concern. Current subtypes of Seasonal influenza A viruses spread in human are influenza A H1N1 influenza A H3N2 and influenza type B viruses. The aim of this study was to determine current strains of the H3N2 and new H1N1 subtypes of influenza A virus from patients suspected influenza infection in 2009 flu pandemic in Golestan province, Iran.
Material and Methods: In this descriptive study, respiratory samples (n = 153) from patients with acute respiratory symptoms were collected in 2009 flu pandemic applied during 2009 pandemic influenza in Golestan province. After reverse transcription of extracted viral RNA, PCR was developed for both H1N1and H3N2subtypes using CDC specific primers.
Results: The mean age of patients was 16.59. Of them 45.1% were male. Thirteen (8.49%) were infected with seasonal influenza H1N1 and 25(16.33%) with seasonal H3N2influenza.
Conclusion: The rate of infection with seasonal H1N1and H3N2is similar to other studies reported from Iran, but lower than the rate reported from other parts of the world.
Key Words: Influenza A Virus, H1N1, H3N2, RT-PCR, Iran
Kashani, L, Okhly, M, Ghaemi, Ea, Behnampour, N., Kashani, E, Okhly, Ho, Fendereski, S., Bazoori, M, Falsafi, L,
Volume 8, Issue 5 (winter[PERSIAN] 2015)
Abstract
Abstract Background and Objective: Along with antibiotics, the use of biological methods to combat bacteria is notably considered. A natural barrier such as amniotic membrane is one of the ways of dealing with bacterial infections. The aim of this study was to determine the antibacterial effect of human amniotic membrane. Materials and Methods: This descriptive study was performed in Dezyani teaching Hospital of Gorgan University of Medical Sciences, Iran. To evaluate the antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli bacteria, 20 amniotic membranes were obtained from postpartum mothers and examined by repeated dilution, diffusion and extraction techniques. Data were collected by observation method and described by mean and standard deviation. Results: The antibacterial activity was found in 15% of the samples against Staphylococcus Aureus and Pseudomonas aeruginosa, while no antibacterial activity was found against E. coli. Given the 15% positive responses, "Diffusion" and "repeated dilution" techniques were more effective in investigating the antibacterial effect of amniotic membrane. Conclusion: The results show the probability of antimicrobial effect of amniotic membrane tissue and it seems that this property can be affected by many factors. Keywords: Amniotic Membrane, Anti-Bacterial Properties, Laboratory Methods
Gol Mohammadi, R, Tabaraei, A, Abbasi, A, Khademi, N, Mahdavian, B, Javid, N, Kaleji, H, Kamasi,a, Bazoori, M, Moradi, A,
Volume 9, Issue 1 (March, April[PERSIAN] 2015)
Abstract
Abstract
Background and Objective: Highly Active Antiretroviral Therapy (HAART) can effectively prevent the progression of HIV-1 replication and increase life expectancy. There are numerous causes of treatment failure and the leading one is drug resistance. Thus, we aimed to determine the HIV RT gene drug resistance mutations in patients treated with antiretroviral medications.
Material and Methods: In this cross - sectional study, venous blood was taken from 130 HIV-positive patients treated with antiretroviral medications. In order to determine drug resistance mutations, RT-PCR and PCR steps were performed using RT gene specific primers. Subtypes and mutations in the virus genome were determined using the Stanford HIV drug resistance sequence database.
Results: In 122 treating patients, most of the major mutations were associated with nucleoside and non-nucleoside drugs. subtype A in 66.4%, subtype D in 26.2% and subtype B in 7.4% of the participants were reported. They were resistant to Nucleoside RT Inhibitor drugs (23.7%) and Non-Nucleoside RT Inhibitor drugs(30.3%). The highest were related to Nevirapine (21.3%) and Efavirenz (19.7%) and the lowest to both Tenofovir and Zidovudine (91.5%).
Conclusion: The use of two nucleoside RT inhibitor drugs combined with one protease inhibitor drug could be effective in the treatment of HAART.
Key words: HIV, Nucleoside RT Inhibitor, Non- Nucleoside RT Inhibitor
Hasan Kaleji, Alijan Tabaraei, Abdollah Abbasi, Naemeh Javeed , Masoud Bazoori , Reza Golmohamadi , Abdolvahab Moradi,
Volume 9, Issue 5 (Nov,Dec-2015 2015)
Abstract
Abstract
Background and Objective: Various cellular factors affect the process of HIV activity. One of these cellular factors are structures known as microRN that are expected to be involved in controlling HIV replication and infectivity. The expression of one or a set of them may represent the patient's clinical conditions. In this study, the expression of miR-29a and miR-29b involved in regulating viral genes’ expression was evaluated in three HIV-positive groups and a healthy control group. Later, the expression level of these microRNAs was compared between the cases and controls.
Methods: Total RNA extraction was performed on the collected samples using RNx-plus kit and then the microRNA expression levels were evaluated using Relative Real-time PCR. The obtained data was entered into SPSS 22 and Graphpad softwares and analyzed using Kruskal-Wallis and Man-Whitney tests. P-value of less than 0.05 was considered as statistical significance level.
Results: The expression level of miR-29a was reduced in patients under treatment and drug-resistant patients ( P ≤ 0.05) . All three HIV-positive groups including people without drug treatment, patients under treatment and drug-resistant patients showed reduced miR-29b expression level compared to control group (P ≤ 0.05).
Conclusion: the decreased expression of miR-29a and miR-29b in patients under treatment and drug-resistant patients indicates an increased viral replication and reduced CD4 cell count. It may be possible to predict the progression of the disease by miRNA measurement or control viral replication using these mir-RNAs that requires further studies.
Keywords: HIV, expression, mir-29a, mir-29b.
