Showing 4 results for Abbassi Daloii
Fariba Rasannezhad, Asieh Abbassi Daloii, Javad Ziaolhagh, Phd Ahmad Abdi,
Volume 0, Issue 0 ( In Press 2024)
Abstract
Background and objectives: The purpose of the present study was to investigate the effect of aerobic exercise and psilocybin after methamphetamine induction on the gene expression of some cerebral cortex semaphorins in female Wistar rats.
Methods: In this experimental study, 40 female rats were placed in five groups; control (C), amphetamine (A), amphetamine-aerobic (AA), amphetamine-psilocybin (AP), amphetamine-psilocybin-aerobic (AAP). Methamphetamine was injected at a dose of 15 mg/kg for 5 days in the morning. Psilocybin was injected at a dose of 1mg/kg. The aerobic training program included running on a treadmill at 20-25 m/min, three days a week for eight weeks. After eight weeks, the genes expression was measured by Real Time PCR method. The data were analyzed by one-way analysis of variance and Tukey's post hoc test at a significance level of P<0.05.
Results: The results showed that the average gene expression of semaphorin 3A, semaphorin 4A and semaphorin 7A in the cerebral cortex of the A group had a significant increase compared to the C group(P=0.001). AA, AP and AAP groups showed a significant decrease in the average expression of semaphorin 3A and semaphorin 4A genes compared to the A group(P=0.001). AAP group had a significant decrease in the average expression of semaphorin 3A gene compared to AA and AP groups(P=0.001). Also, the AAP group showed a significant decrease in semaphorin 7A compared to the AP group(P=0.007).
Conclusion: According to the results, aerobic training and psilocybin supplementation can help reduce semaphorins in the cerebral cortex in rats induced with methamphetamine.
Asieh Abbassi Daloii , Esmatalsadat Mousavi ,
Volume 10, Issue 6 (Nov-Dec-2016 2016)
Abstract
ABSTRACT
Background and Objective: The present study aims at investigating the possible effect of 8-week aerobic exercise on undercarboxylated osteocalcin and beta cell function in postmenopausal women.
Methods: The study included 20 postmenopausal women with mean weight, height and body mass index of 78.94 ± 5.72 kg, age 48.69 ± 3.21 years, 160.37 ± 4.12 cm and 30.72 ± 2.37 kg/m2. The participants were randomly selected and divided into experimental and control groups. Blood samples were taken 48 hours before the experiment and after eight weeks of exercise. Aerobic exercise was performed for eight weeks, three sessions per week with intensity of 65-70% of heart rate. Data analysis for intragroup and intergroup differences was done using paired and independent t-test, respectively. P-values less than 0.05 were considered statistically significant.
Results: The level of undercarboxylated osteocalcin in the experimental group decreased significantly compared to control group (P<0.049). The level of beta cell function index in the experimental group increased significantly after the 8-week exercise program compared to control group (P<0.014).
Conclusion: Exercise increases the level of undercarboxylated osteocalcin in postmenopausal women that has important consequences, especially for those at risk of developing diabetes.
Keywords: Exercise, Osteocalcin, Hemoglobin A, Glycosylated, Postmenopause.
Hadi Alinejad, Asieh Abbassi Daloii, Parvin Farzanegi, Ahmad Abdi,
Volume 15, Issue 1 (Jan-Feb 2021)
Abstract
Background and Objective: Osteoarthritis (OA) and cardiovascular disease (CVD) are highly prevalent. The purpose of the present study was to investigate the effect of regular aerobic training and hyaluronic acid on cardiac tissue Wnt signaling pathway in experimental model of knee OA.
Methods: 42 male rats were divided into 6 groups (7 in each group): 1) control, 2) patient, 3) salin, 4) HA, 5) exercise, and 6) exercise + HA. In the training groups, the OA model was first induced, followed by 5 days of running on the treadmill for 5 weeks. Hyaluronic acid was injected intra-articularly. After 12 to 14 hours of fasting and 72 hours after the last training session, cardiac tissue sampling was performed for β-catenin and glycogen synthase kinase-3 (GSK-3β) analysis. The expression of the β-catenin and GSK-3β genes in the cardiac tissue was analyzed by RT-PCR. Data analysis was performed using one-way ANOVA if a significant difference was observed by Tukey's post hoc test (P <0.05).
Results: Induction of OA in rats led to a significant increase in β-catenin gene and a significant decrease in cardiac tissue GSK3 gene compared to healthy control group. The results also showed that regular aerobic training, hyaluronic acid injection, and a combination of both treatments reduced the cateninβ gene and increased the cardiac tissue GSK3 gene compared to the rats of OA group.
Conclusion: Regular aerobic training in combination with hyaluronic acid may exert its protective effect by reducing the expression of β-catenin and increasing the expression of cardiac tissue GSK-3β gene ; this may be caused by the heart disease in the model, empirically preventing osteoarthritis.
Seyedabdullah Mosavi, Alireza Barari, Asie Abbassi Daloii,
Volume 17, Issue 5 (Sep-Oct 2023)
Abstract
Background: Significant economic consequences can lead to various problems and complications, including medical complications. Coronary artery disease (CAD), a serious health threat with increasing prevalence, is a major cause of death and mortality worldwide. This study aimed to investigate the effects of a special training program on cytochrome P450 (CYP) gene expression and reactive oxygen species (ROS) levels in patients with coronary artery bypass surgery.
Methods: This semi-experimental study was conducted on 16 patients who underwent coronary artery surgery in Babol City, Iran. The patients were selected using a random sampling method and divided into 2 groups: experimental and control groups. The experimental group engaged in an exercise program consisting of 3 sessions per week for a duration of 8 weeks. The expression levels of CYP and ROS genes were measured by the real-time polymerase chain reaction (PCR) method. The analysis was performed by comparing covariances and means.
Results: ROS gene expression levels significantly decreased in the experimental group than in the control group (P=0.003). However, there was no significant difference in P450 levels between the experimental and control groups (P=0.99).
Conclusion: Special exercises reduced ROS expression and increased P450 expression in patients who had coronary bypass surgery. There is a probability that special exercises, can effectively prevent heart damage by increasing antioxidant capacity and reducing ROS.
