Showing 12 results for Abbasi
A Moradi, A Abbasi, Ar Mansourian, A Ahmadi, A Sarikhani, M Bazoori,
Volume 1, Issue 2 (Autumn – Winter 2008[PERSIAN] 2007)
Abstract
Abstract: Introduction: Influenza is highly transmitted disease and vaccination is the most effective way to prevent influenza. This research was designed to study the variation of serum antibody level among the subjects had already been vaccinated against influenza. Materials and Methods: This research is a descriptive-analytical study, which was carried out on 196 subjects who had influenza vaccination (influvac 2005/2006) and 200 subjects matched by the vaccinated subjects, by age. The subject's serums were prepared seven weeks after influenza vaccination, and the control group's serums were also prepared. The serum antibody level was determined by haemaglutination inhibition test. Results: The mean age of case group is 52.2±11 and control group 48.64±5.17.The antibody titre of 115 of Vaccinated group and 15 of control is less than 40 1 The mean antibody titer of vaccinated subjects and control group is 143.4 ± 10.89 and 18.34± 3.2, respectively. The difference is statistically significant (P value=0.000). Conclusion: The findings show that the mean titer of antibody in vaccinated and control group is statistically different. It means that the influenza vaccine had a good efficacy. Key words: Vaccination, Influenza, Gorgan.
A Moradi, A Abbasi,
Volume 1, Issue 2 (Autumn – Winter 2008[PERSIAN] 2007)
Abstract
Abstract False positive results are the major problem influencing interpretation of Clinical Laboratory test. They are originated mostly in the other diseases, technical errors and the recent vaccination. The problem has been presented since 1991 is positive HIV test after influenza Vaccination (1). The False positive has been reported in Cases using Eliza, one of The most common test to screen HIV, and in people vaccinated against influenza.(2) In a study carried out in 1992, nearly 1.7% of recently vaccinated subjects had false positive HIV(3) while Mackenzie's report was 0.6% to 1.7%. (4) In another study, the rate of false positive is 0.9% in 10-20 year-old subjects and 3.1% in subjects aged over 60. (5). In addition, the vaccinated cases suffered from infecfious disorders are highly predisposed to false positive HIV. (5) Considering the aforementioned points, we decided to determine false positive HIV in 196 vaccinated Cases set off for Mecca. (2004, Gorgan). After thorough examination of the cases , we injected them Influac (2005/2006) composing of 45my heamagglutinine and neuramidase proteins extracted from Viruses of: 1-A/California/7/2004 (H3N2)-Like strain (A/New York/55/2004 NYMC X-157) 2-A/New Caledonia/20/99 (H1N1)-Like strain (A/New Caledonia/20/99 IVR-116) 3-B/Shanghai/361/2002-like strain (B/Jiangsu/10/2003) in 196 healthy influenza vaccinated group. Analysis of HIV anti-body was assessed using Elisa method (DiaPro Kit Italy). After seven weeks, HIV anti-body was analyzed using Eliza method (Diapro kit, Italy) Conclusion: The results show that no one has positive HIV. These finding is not in accord with previous studies. It may be due to the recent use of vaccine modified and specialized and the use of Eliza
S S Bani Aghil, S Abbasi, M Arab, M S Seyedein,
Volume 3, Issue 2 (Autumn – Winter 2010[PERSIAN] 2009)
Abstract
Abstract Background and objectives: Hepatitis C virus (HCV), Human immuno deficiency virus (HIV) and Hepatitis B Virus (HBV) are the three main agents of Communicable disorders transmitted by blood transfusion. The survey of these virus-caused infections in Blood donors can display epidemiology of infections in province and be useful for evaluating donors’ health. The aim of this study was serologic Study of infections caused by HBV, HCV and HIV in Blood donors of Golestan province, Iran. Material and Methods: This retrospective study was carried out on all files of blood donors, referred to Golestan Blood transfusion Services, with positive Lab results. We assess the prevalence of HBV, HCV and HIV, and demographic data of blood donors and analyzed the data by chi-square, using SPSS soft ware. Results: During 2006-2008, 128198 people have donated in Golestan province. The prevalence of HBV during 2006-2008 is respectively 1.25%, 0.95% and 0.11% HCV is 14%, 13% and of HIV is 0.0015 %( just 2 cases in 2007). The prevalence of HBV, HIV and HCV is higher in male, married and donors with high school diploma. Also the prevalence of HIV, HCV and HBV is lower in regular donors rather the first time donors. Conclusion: It seems that the prevalence of HBV and HCV is decreased during three years. This decrease can be due to physician’s supervision for selecting healthy donor and availability of donors’ medical record. Key words: Golestan Province, HIV, HCV, HBV, demographic,prevalence
Abbasi A (md), Tajbakhsh R (md), Kabotari M, Zhand S (msc), Tabarraei A (phd), ,
Volume 6, Issue 1 (spring-summer[PERSIAN] 2012)
Abstract
Abstract Background and objectives: Hepatitis B virus infection is a major health problem in worldwide. The prevalence of Occult and chronic HBV in hemodialysis patients is higher than standard in developing countries. People with occult HBV are negative for HBV surface antigen (HBsAg) but positive for HBV-DNA. We aimed to evaluate occult hepatitis B infection in patients under hemodialysis in Panje-Azar hospital in Gorgan. Material and Methods: In this study, taken place from 2009 to 2010, the participants were 100 hemodialysis patients with administration of complete HBV vaccination with negative test for HBsAg. After preparing 10 milliliter blood sample, HBV DNA testing was performed by polymerase chain reaction (PCR). Result: The mean age of the patients is 54.60 years. They are male (48%) and female (52%). They have been under hemodialysis for 48 months, averagely. There has not been any HBV-DNA in HBsAg negative patients under hemodialysis. The rate of occult hepatitis B infection in these end stage renal disease (ESRD) patients was zero. Conclusion: Results indicate that there is no any occult HBV infection in ESRD patients under hemodialysis in Gorgan, which is similar to some studies. The results could be justified by complete vaccination of the patients. Key words: Occult Hepatitis B, Hemodialysis, HBsAg, Gorgan
F Koohsar, A Amini, Aa Ayatollahi, F Niknejad, Z Abbasi Nejat,
Volume 7, Issue 3 (Autumn 2013)
Abstract
Abstract
Background and Objective: In many countries, especially in developing countries, diarrheal diseases is one of the most important causes of mortality. In these countries, due to availability transfer conditions of parasitic infections, (pathogenic and non-pathogenic parasite), have a high prevalence. This study aimed was determining the prevalence of Parasites causing diarrhea in Gorgan .
Material and Methods: This cross-sectional study was performed on 1086 Patients with acute diarrhea. The test was performing by the wetmount and formalin-ether concentration method according to WHO protocol.
Results: From 1086 patients in study, 197 (18.1%) were infected by intestinal parasites, that 141 (13%) were infected with Protozoan and 79 (7.27%) were infected with intestinal worms. The prevalence of wet mount method was, Entamoebahistolytica in 69 (6.4%), Giardia lamblia in 27 (2.5%), Entamoeba coli in 15 (1.4%), Chilomastixmesnili in 8 (0.7%), and with formalin-ether method was Hymenolepis nana in 26 (2.4%), Trichostrongylus in 16 (1.5%), Enterobiusvermicularis in 10 (0.9%).
Conclusion: The high prevalence of Entamoeba histolytica, is indicating protozoan importance as a cause of acute diarrhea.
Keywords: Intestinal Parasites Diarrhea Wetmount Formalin Ether Gorgan
Gol Mohammadi, R, Tabaraei, A, Abbasi, A, Khademi, N, Mahdavian, B, Javid, N, Kaleji, H, Kamasi,a, Bazoori, M, Moradi, A,
Volume 9, Issue 1 (March, April[PERSIAN] 2015)
Abstract
Abstract
Background and Objective: Highly Active Antiretroviral Therapy (HAART) can effectively prevent the progression of HIV-1 replication and increase life expectancy. There are numerous causes of treatment failure and the leading one is drug resistance. Thus, we aimed to determine the HIV RT gene drug resistance mutations in patients treated with antiretroviral medications.
Material and Methods: In this cross - sectional study, venous blood was taken from 130 HIV-positive patients treated with antiretroviral medications. In order to determine drug resistance mutations, RT-PCR and PCR steps were performed using RT gene specific primers. Subtypes and mutations in the virus genome were determined using the Stanford HIV drug resistance sequence database.
Results: In 122 treating patients, most of the major mutations were associated with nucleoside and non-nucleoside drugs. subtype A in 66.4%, subtype D in 26.2% and subtype B in 7.4% of the participants were reported. They were resistant to Nucleoside RT Inhibitor drugs (23.7%) and Non-Nucleoside RT Inhibitor drugs(30.3%). The highest were related to Nevirapine (21.3%) and Efavirenz (19.7%) and the lowest to both Tenofovir and Zidovudine (91.5%).
Conclusion: The use of two nucleoside RT inhibitor drugs combined with one protease inhibitor drug could be effective in the treatment of HAART.
Key words: HIV, Nucleoside RT Inhibitor, Non- Nucleoside RT Inhibitor
Shafiee, F, Khosravi, Ad, Azarpira, S, Babaie Barkalaie, A, Abbasi Montazeri, E,
Volume 9, Issue 3 (Jul,Aug2015[PERSIAN] 2015)
Abstract
Background and Objectives: Pseudomonas aeruginosa is the most common organism, which is separated from the burn infections. Due to increased antibiotic resistance, there are many problems to deal with the infections caused by Pseudomonas aeruginosa. This study aimed to determine the resistance to antibiotics against clinical isolates of Pseudomonas using phenotype methods.
Material and Methods: 100 strains of Pseudomonas aeruginosa were collected from the burn patients in Taleghani hospital in Ahwaz, Iran, during a six-month period. After phenotypically initial identification, antibiotic sensitivity of isolated strains to conventional antibiotics against Pseudomonas aeruginosa was determined using a disk diffusion technique, and Phenotypic screening for MBLs production was performed.
Results: the maximum percentage was related to wound infection and the frequencies of the resistance to imipenem, meropenem, piperacillin, piperacillin-tazobactam, ceftazidime, gentamicin, amikacin, and ciprofloxacin, doripenem, ertapenem and colistin sulphate, were 70%, 53%, 83%, 67%, 91%, 88%, 84%, 84%, 33%, 90%, and 0%, respectively. The use of CD Test methods was approved for determining resistance to Carbapenems.
Conclusion: antibiotic resistance to Pseudomonas aeruginosa is increasing and colistin sulphate is the most effective antibiotic.
Keywords: Pseudomonas Aeruginosa; Burn Infection; Antibiotic Resistance.
Hasan Kaleji, Alijan Tabaraei, Abdollah Abbasi, Naemeh Javeed , Masoud Bazoori , Reza Golmohamadi , Abdolvahab Moradi,
Volume 9, Issue 5 (Nov,Dec-2015 2015)
Abstract
Abstract
Background and Objective: Various cellular factors affect the process of HIV activity. One of these cellular factors are structures known as microRN that are expected to be involved in controlling HIV replication and infectivity. The expression of one or a set of them may represent the patient's clinical conditions. In this study, the expression of miR-29a and miR-29b involved in regulating viral genes’ expression was evaluated in three HIV-positive groups and a healthy control group. Later, the expression level of these microRNAs was compared between the cases and controls.
Methods: Total RNA extraction was performed on the collected samples using RNx-plus kit and then the microRNA expression levels were evaluated using Relative Real-time PCR. The obtained data was entered into SPSS 22 and Graphpad softwares and analyzed using Kruskal-Wallis and Man-Whitney tests. P-value of less than 0.05 was considered as statistical significance level.
Results: The expression level of miR-29a was reduced in patients under treatment and drug-resistant patients ( P ≤ 0.05) . All three HIV-positive groups including people without drug treatment, patients under treatment and drug-resistant patients showed reduced miR-29b expression level compared to control group (P ≤ 0.05).
Conclusion: the decreased expression of miR-29a and miR-29b in patients under treatment and drug-resistant patients indicates an increased viral replication and reduced CD4 cell count. It may be possible to predict the progression of the disease by miRNA measurement or control viral replication using these mir-RNAs that requires further studies.
Keywords: HIV, expression, mir-29a, mir-29b.
Hadis Musavi , Abolfazl Fattah , Mojtaba Abbasi ,
Volume 13, Issue 3 (May-Jun 2019)
Abstract
ABSTRACT
Background and Objectives: Prostate cancer is a highly prevalent malignancy with a high mortality rate in men. Many studies have investigated the diagnostic value of various genes involved in prostate cancer, but there is no data for Kallikrein 2 (KLK2) and Kallikrein 3 (KLK3) expression patterns among Iranian patients. Therefore, we aimed to evaluate the expression of these two genes in Iranian patients with prostate cancer.
Methods: In this case-control study, three groups consisting of healthy individuals, patients with benign prostatic hyperplasia (BPH) and patients with prostate cancer were studied. Peripheral blood samples were collected from all subjects, mRNA was extracted after cell lysis, and cDNA was synthesized. Real-time PCR was performed to assess gene expression levels relative to a reference gene (18s rRNA gene).
Results: The KLK2 gene was overexpressed in patients with prostate cancer. KLK2 expression differed significantly between the cancer patients and controls. Relative expression of the KLK3 gene in the BPH group was higher than that in the control and cancer groups. However, we observed no significant difference in the expression of KLK3 between the control and cancer subjects.
Conclusion: We demonstrate that analysis of KLK2 expression is a favorable method of diagnosing prostate cancer and discriminating normal individuals from those with BPH or prostate cancer. We also found that the KLK3 gene is highly overexpressed in individuals with BPH, which might indicate that this gene is not cancer-specific.
Keywords: Prostatic Neoplasm, Prostatic Hyperplasia, Kallikreins, Gene Expression.
Mojtaba Abbasi, Amirhooman Asadi, Hadis Musavi,
Volume 13, Issue 6 (Nov-Dec 2019)
Abstract
Background and Objectives: Reduced insulin secretion in Type II Diabetes Mellitus (T2DM) results in fat accumulation in hepatocytes and increase in liver enzymes. The hepatocyte destruction due to non-alcoholic fatty liver is associated with increased risk of cardiovascular diseases. Therefore, the aim of this study is to evaluate the association of liver transaminases with lipid profile in T2DM patients compared to healthy subjects.
Methods: A total of 1000 subjects (500 males and females with T2DM and 500 healthy subjects) participated in this case-control study. Diagnosis of T2DM was made based on the World Health Organization (WHO) criteria. Fasting blood samples (5 ml) were obtained from all subjects in the morning and the serum was extracted for the assessment of biochemical parameters was used to compare parameters between healthy and T2DM patients. Data were analyzed by SPSS version 20 and using Mann-Whitney test and Spearman correlation coefficient.
Results: The serum total cholesterol (TCH), triglyceride, Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), TCH/high density lipoprotein (HDL-C) ratio and atherogenecity index plasma were significantly higher in T2DM group compared to healthy individuals (p≤0.006). Among the lipid profile parameters only Risk ratio (TCH/HDL-C) was positively correlated with ALT (p=0.037) while no significant correlation was observed for other variables (P>0.05)
Conclusion: T2DM Patients have higher lipid profile, atherogenecity index and liver enzymes compared to healthy individuals. Furthermore, TCH/HDL-C was significantly correlated with ALT.
Alireza Sobhani, Hakimeh S. Sajjadi, Touba Abbasi,
Volume 17, Issue 4 (Jul-Aug 2023)
Abstract
Alireza Sobhani1 
,
Hakimeh S. Sajjadi 2,
Touba Abbasi1
Lymphangioma circumscriptum is a rare congenital proliferation of lymphatic vessels that may occur anywhere on the skin and mucous membranes. Based on the depth and the size of abnormal lymph vessels, these lesions are divided into two groups: the superficial vesicles are called lymphangioma circumscriptum and the more deep-seated group includes cavernous lymphangioma, cystic hygroma, and benign lymphangioendothelioma. The differential diagnosis of lymphangioma includes herpes zoster, herpes simplex, molluscum contagiosum, cutaneous melanoma, dermatitis herpetiformis, and viral warts. Herein, we report a rare case of giant cutaneous lymphangioma circumscriptum with emphasis on histopathology and differential diagnosis. Our case was a 14-year-old boy with a history of multiple, clear, pink, red, and brown vesicles protruded as a patch of wart-like growths on the flank’s skin since the 6 months of age. Histopathologic examination indicated presence of multiple thin-walled dilated lymphatic spaces in the papillary dermis lined with a single layer of endothelial cells filled with finely granular hyaline material.
Sedigheh Shirkhani, Alireza Barari, Asieh Abbasi Daloii, Mehrdad Saravi,
Volume 18, Issue 1 (Jan-Feb 2024)
Abstract
Background: Cardiovascular diseases, especially coronary artery problems, are the main causes of death. The aim of this study was to evaluate the expression of NOs and NOX2 in coronary artery patients after aerobic exercise and omega-3 intake.
Methods: The present study was a quasi-experimental study in which 32 men with coronary artery disease in the age range of 55 to 65 years were selected and randomly divided into 4 groups: control, exercise, omega-3, and omega-3 + exercise. The training program consisted of 8 weeks of intermittent running training, 3 sessions per week, with an intensity of 55 to 65% of the subjects' heart rate reserve and with an emphasis on gradual overload. Subjects consumed 1000 mg of omega-3 daily.
Results: There was a significant increase (P <0.0001) in the mean expression of the NOS gene in the exercise + omega-3 group compared to the control group. The mean ratio of NOX gene expression changes in the exercise group, omega-3, and the combination of exercise + omega-3 was significantly reduced compared to the control group (P <0.0001).
Conclusion: According to the results of the present study, the ability of exercise and omega-3 supplementation to reduce the level of oxidant stress and increase homeostasis control in coronary artery insufficiency shows an important molecular mechanism that underlies the benefits of these interventions.
