This paper should be cited as: Hashemi,J. Asadi, J. Amiriani,T. Beshrat,S. Roshandel, GH. Joshaghani, HR.
The
Comparison of Serum Vitamins A and E in Irritable Bowel Syndrome Patients with
Control Group
Hashemi,J.(MSc)1, Asadi, J.(PhD)2, Amiriani,T.(MD)3, Beshrat,S.(MSc)4,
Roshandel, GH (MSc), Joshaghani,
HR.(PhD)*6
1. MSc of Biochemistry,Faculty
of Medical Sciences,Golestan University of Medical
Science, Gorgan,Iran
2. Assitant
Professor of Biochemistry, Biochemistry and Metabolic Disorders Research Center,Golestan University of Medical Science, Gorgan,Iran
3. Gastroenterologist,
Gastroenterology and Hepatology, Golestan
Research of Gastroenterology and Hepatology,Golestan
University of Medical Science, Gorgan,Iran
4. PhD Student of Cellular and Molecular, Golestan
Research of Gastroenterology, and Hepatology, Golestan University of Medical Science, Gorgan,Iran
5. PhD Student of Epidemiology, Golestan Research of
Gastroenterology, and Hepatology, Golestan
University of Medical Science, Gorgan,Iran
6. Associated Professor of Biochemistry,Golestan
Research of Gastroenterology and Hepatology, Golestan University of Medical Science, Gorgan,Iran
Abstract
Background and objectives:
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases.
It is a functional bowel disorder characterized by chronic abdominal pain and
alternation of bowel habits with no structural abnormality. The prevalence of
this disease was estimated 10-20 percent in the world. However, the cause of
IBS is still unknown. Regarding
to intestinal absorption disorder of nutrients, the malabsorption
of vitamin may occur. The aim of this study is to evaluate the effectiveness of
IBS on serum levels of vitamins A and E.
Materials & Methods: This case - control study was done on 94 patients whom their IBS disease were confirmed by a gastroenterologist in Golestan province. The control group was selected from healthy people, who didn't show any signs of digestive problems in past two years. The age and sex were matched with the cases group. Using HPLC method, Fasting blood samples were collected .Followed by measurement of Serum levels of vitamins A and E.
Results: the meanserum levelsof vitamin A and E In patients and control group were 57.0 ± 114.8μg / dl and23.8 ± 55.9 μg / dl,and 0.50 ± 0.24 mg / dland1.93 ± 1.86 mg / dl, respectively. (P <0.05). In men, the deficiency of Vitamin A and E, were7.70 and 7.10 percent and 6.76 and 3.7 in women. (P <0.05).In general, 1.1percent of IBS patients showed Vitamin A deficiency and 93.6 percent of them had vitamin E deficiency (P <0.05).
Conclusion: In this study, a significant decrease in vitamin E levels was observed in patients with IBS. Due to antioxidant function of vitamin E, the deficiency of this Vitamin, can increase the oxidative factors leading to intestinal damages and it is expected to decrease the amount of vitamins, subsequently
Keywords: irritable bowel syndrome, Vitamin A, Vitamin E, Gorgan
Corresponding author:Joshaghani, HR
Email: hr_joshaghani@yahoo.com
Received: 6
Nov 2011 Revised: 3 Dec 2012 Accepted: 4 Dec 2012