This paper should be cited as: Sedighi, I. Alikhani,
MY. Nakhaee, S. Karami, P.
Antibiotic Resistance Patterns in Enteric
and Uropathogenic Strains of Escherichia Coli
in Children
Sedighi, I.
(MD)1, Alikhani, MY. (PhD)2, Nakhaee, S. (MD)3, Karami, P. (MSc)4
1. Associate Professor of Pediatrics, Department of
Pediatrics, School of Medicine, Hamadan University of Medical
Sciences, Hamadan,
Iran
2. Associate Professor of Microbiology, Department of
Microbiology, School
of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3. Resident of Pediatrics, Department
of Pediatrics School
of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4. MSc of Microbiology, Hamadan University of Medical
Sciences, Hamadan, Iran
Abstract
Background
and Objective: Escherichia coli is the most common cause of urinary tract infections in children
and the leading cause of intra-abdominal infections (peritonitis and abscess) followed intestinal injuries. Urinary tract infection,
including cystitis and pyelonephritis, is a common childhood infection. E.
coli causes more than 90 percent of the community acquired and 50% of
hospital acquired urinary tract infections; therefore, the determination of E.
coli antibiotic susceptibility is a paramount importance to clinical and
epidemiological purposes.
Material
and
Methods: In this cross-sectional study, 50 E. coli
strains isolated from urine samples of children less than 7 years of age with
urinary tract infections. They were compared for drug susceptibility testing by
disc diffusion method with 50 strains of Escherichia coli isolated from
stool samples of healthy children with the same age and sex pattern.
Results: The actual amount of drug sensitivity of uropathogenic and intestinal Escherichia coli strains
to amikacin was 94 and 100%, nitrofurantoin
90 and 88%, gentamicin 66 and 94%, cefixime 56 and
60%, nalidixic acid 38 and 44% and to cotrimoxazole 28 and 32%, respectively.
Conclusion: the rate of resistance to gentamicin, Cefixime and nalidixic acid in
urinary tract infection isolates were more than intestinal strains. The highest
rate of drug resistance in urinary Escherichia coli isolates was
associated with cotrimoxazole and the lowest one with
amikacin.
Keywords: Escherichia Coli, Intra-Abdominal Infection, Drug
Resistance, Urinary Tract Infection, Children
Corresponding Author: Alikhani, MY.
Email: alikhani@umsha.ac.ir
Received: 3
Sep 2013
Revised: 24 Nov 2013
Accepted: 30 Dec 2013