This paper should be cited as: Royani, S. Alijanpor, S. Shirbaghaei, Z. Khorasaninejad, R. Roshandel, GH. Ayatollahi, AA. Joshaghani, HR.

The Comparison of Serum Vitamin D Level in Patients with Iron Deficiency Anemia and Minor Thalassemia

Royani, S. (MSc)*1, Alijanpor, S. (BSc)2, Shirbaghaei, Z. (BSc)3, Khorasaninejad, R. (BSc)4, Roshandel, GH.5, Ayatollahi, AA.6, Joshaghani, HR.7

1. BSc of Nursing and MSc of Strategic Management, Medical Laboratory Kavosh, Gorgn, Iran

2. MSc student of Genetics, Golestan University of Medical Sciences, Gorgan, Iran

3. Msc Student of Immunology, Tehran University of Medical Sciences, Tehran, Iran

4. Student of Medicine, School of Medicine, Golestan University of Medical Sciences, Golestan, Iran

5. PhD Student of Epidemiology, Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran

6. Medical Doctor of Laboratory, Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran

7. Associated Professor of Biochemistry, Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran

Abstract

Background and Objective: Of the most common hypochromic microcytic anemia are iron deficiency anemia and minor thalassemia, which are common in Iran and their differential diagnosis is extremely important. The level of 25-hydroxy vitamin D is theindication of vitamin D blood status. The aim of this study was to compare serum levels of vitamin D in people with minor thalassemia and iron deficiency anemia with healthy subjects in order to investigate the relationship between vitamin D deficiency and iron absorption.

Material and Methods: In this case-control study, 24 patients with minor thalassemia, 20 patients with iron deficiency anemia and 24 healthy individuals participated. Groups were matched for age and sex. Testing of Vitamin D level by ELISA, ferritin by quantitative luminescence method and HbA2 by column chromatography was carried out.

Results: The number of individuals with low level of vitamin D in iron deficiency group is 15 (75%), in minor thalassemia group is 8 (33/3%) and in the control group 11 (45.8%).

Conclusion:In this study, the highest percentage of vitamin D deficiency is observed in cases with iron deficiency anemia. Because of association between vitamin D and anemia, iron and vitamin D supplementation is recommended to enrich the diet.

Keywords:Anemia;Minor Thalassemia;Iron Deficiency Anemia;Vitamin D

Corresponding author:Joshaghani, HR.

Email: hr_joshaghani@yahoo.com

Received 19 Dec 2012 Revised 5 Jun 2013 Accepted10 Jun 2013