en بیوشیمی Biochemistry تحقيقي Original Paper <h2><strong>Background and objectives:</strong> As a chronic inflammatory airway disease, asthma can increase level of markers of inflammation and muscle damage. In this study, we aimed to evaluate the effects of short-term continuous aerobic exercise combined with vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), lactate dehydrogenase (LDH) and creatine kinase (CK) levels in asthmatic women.</h2> <h2><strong>Methods:</strong> In this study, 30 overweight (body mass index=26.97&plusmn; 1.24 kg/m²) women with mild to moderate asthma were purposefully selected.. The subjects received a vitamin D tablet with a daily dose of 1000 IU for six weeks. The training protocol consisted of two sessions of Balke treadmill test (one session before and one session after the vitamin D supplementation). Blood samples were taken before and immediately after the exercise and before and after vitamin D supplementation. Repeated measures ANOVA was used to evaluate changes in the levels of hs-CRP, CK and LDH.</h2> <h2><strong>Results:</strong> The variables were not significantly affected by the exercise and vitamin D supplementation (P>0.05).</h2> <h2><strong>Conclusion:</strong> It seems that a single session of short-term aerobic exercise and six weeks of vitamin D supplementation do not significantly affect hs-CRP, CK and LDH levels in asthmatic women.</h2> Exercise,Vitamin D,C-Reactive Protein, 28 32 http://mlj.goums.ac.ir/browse.php?a_code=A-10-931-1&slc_lang=en&sid=1 Maryam Parvizifar m.parvizi.114@gmail.com 100319475328460019922 100319475328460019922 Yes Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran Mohsen Ghanbarzadeh ghanbarzadeh213@gmail.com 100319475328460019923 100319475328460019923 No Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran Saeid Shakerian sashakeryan@gmail.com 100319475328460019924 100319475328460019924 No Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran Heshmatollah Tavakol heshmattavakol20@gmail.com 100319475328460019925 100319475328460019925 No Department of Internal Medicine, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran