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mljgoums 2024, 18(5): 31-33 |
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Noha Alsharifi N, Gholipur M, Ghorbani S, Mohammadzadeh F, Khajeniazi S. Association among liver biochemical parameters, thyroid gland hormones, and TNF-Alpha in hypothyroid patients compared to euthyroid subjects. mljgoums 2024; 18 (5) :31-33
URL: http://mlj.goums.ac.ir/article-1-1792-en.html
URL: http://mlj.goums.ac.ir/article-1-1792-en.html
Noori Noha Alsharifi1 
, Mahin Gholipur2 , Somayeh Ghorbani3 , Fatemeh Mohammadzadeh2 , Safoura Khajeniazi4
, Mahin Gholipur2 , Somayeh Ghorbani3 , Fatemeh Mohammadzadeh2 , Safoura Khajeniazi4
1- Department of Clinical Biochemistry, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran
4- Department of Clinical Biochemistry, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran ; Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,niazie80@gmail.com
2- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran
4- Department of Clinical Biochemistry, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran ; Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (763 Views)
Background: Tumor necrosis factor alpha (TNFα) is a 17 kDa, an important soluble pro-inflammatory cytokine, which is involved in some tissue dysfunctions, including thyroid and liver tissue. In spite of its role in thyroid and tissue damage separately, the relationship between this factor and these two disorders has not been clarified. The aim of the present study was to evaluate liver biochemical parameters and TNFα in hypothyroid patients compared to euthyroid subjects.
Methods: To achieve this purpose, samples were transferred into tubes without anticoagulants and then centrifuged immediately to separate the serum. All markers in the serum were measured using commercial kits, including T3, T4, TSH, and TNFα, which were detected using the ELISA method. Liver function tests, including albumin, total bilirubin, and total protein were measured by spectroscopy and the colorimetric method, respectively. In addition, AST, ALT, ALP, and GGT were detected using enzymatic methods.
Results: Our results showed that the level of TNFα in hypothyroid patients was significantly higher than that in normal individuals (P = 0.009). TNFα had a significantly positive correlation with TSH and T3 but a negative correlation with T4. Furthermore, AST, ALT, and GGT had a positive correlation with TSH and a negative correlation with albumin, total protein, and total bilirubin. These correlations were insignificant (P < 0.05).
Conclusion: According to our data, the positive correlation of TSH with both TNFα and liver function tests may indicate a relationship between thyroid and liver function with each other.
Methods: To achieve this purpose, samples were transferred into tubes without anticoagulants and then centrifuged immediately to separate the serum. All markers in the serum were measured using commercial kits, including T3, T4, TSH, and TNFα, which were detected using the ELISA method. Liver function tests, including albumin, total bilirubin, and total protein were measured by spectroscopy and the colorimetric method, respectively. In addition, AST, ALT, ALP, and GGT were detected using enzymatic methods.
Results: Our results showed that the level of TNFα in hypothyroid patients was significantly higher than that in normal individuals (P = 0.009). TNFα had a significantly positive correlation with TSH and T3 but a negative correlation with T4. Furthermore, AST, ALT, and GGT had a positive correlation with TSH and a negative correlation with albumin, total protein, and total bilirubin. These correlations were insignificant (P < 0.05).
Conclusion: According to our data, the positive correlation of TSH with both TNFα and liver function tests may indicate a relationship between thyroid and liver function with each other.
Keywords: Hypothyroidism, Tumor necrosis factor-alpha, Liver function tests, Gamma-Glutamyltransferase, Total protein
Research Article: Research Article |
Subject:
Biochemistry
Received: 2024/03/13 | Accepted: 2024/07/9 | Published: 2024/10/21 | ePublished: 2024/10/21
Received: 2024/03/13 | Accepted: 2024/07/9 | Published: 2024/10/21 | ePublished: 2024/10/21
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