Thu, Apr 3, 2025
1- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,mthhematology@gmail.com
2- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (474 Views)
Introduction:
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, disturbed lipid metabolism and cardiovascular disease (CVD). Worsening of glycemic control resulting in lipid and lipoprotein abnormalities suggests that dyslipidemia is secondary to insulin resistance or factors closely related to insulin resistance. Glaciated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic control and is a form of hemoglobin that is chemically is a process called post translational glycosylation that reflects the amount of plasma glucose concentration during the recent 2-3 months.
Methods:
In this cross-sectional study blood collection was done from 598 cases who attended … the laboratory. In two groups categorized of DM and non-DM cases, HbA1c and total cholesterol (T-chol), TG, LDL-C, and HDL-c were determined.
Results:
There was significant association between HbA1c and lipid profiles of DM patients.
Conclusion:
According to the results of this study, HbA1c could be used as a viable marker of lipid and glycemic control in diabetics.
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, disturbed lipid metabolism and cardiovascular disease (CVD). Worsening of glycemic control resulting in lipid and lipoprotein abnormalities suggests that dyslipidemia is secondary to insulin resistance or factors closely related to insulin resistance. Glaciated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic control and is a form of hemoglobin that is chemically is a process called post translational glycosylation that reflects the amount of plasma glucose concentration during the recent 2-3 months.
Methods:
In this cross-sectional study blood collection was done from 598 cases who attended … the laboratory. In two groups categorized of DM and non-DM cases, HbA1c and total cholesterol (T-chol), TG, LDL-C, and HDL-c were determined.
Results:
There was significant association between HbA1c and lipid profiles of DM patients.
Conclusion:
According to the results of this study, HbA1c could be used as a viable marker of lipid and glycemic control in diabetics.
Research Article: Research Article |
Subject:
Biochemistry
Received: 2024/01/1 | Accepted: 2024/07/9
Received: 2024/01/1 | Accepted: 2024/07/9
References
1. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019; 157: 107843. [View at Publisher] [DOI] [PMID] [Google Scholar]
2. Bhowmik B, Siddiquee T, Mujumder A, Afsana F, Ahmed T, Mdala IA, et al. Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population. Int J Environ Res Public Health. 2018; 15(9): 1944. [View at Publisher] [DOI] [PMID] [Google Scholar]
3. B Aziz S, K. Mohi aldeen S, K. Chlimeran S. Evaluation of lipid profile in patients with type II diabetes mellitus on different treatment. Tikrit J. Pharm. Sci. 2023; 9(2): 253-61. [View at Publisher] [DOI] [Google Scholar]
4. Basit KA, Ng Fat L, Gregg EW. Changes in cardiovascular risk factors for diabetes among young versus older English adult populations. J Public Health (Berl.) 2023. [View at Publisher] [DOI] [Google Scholar]
5. McGill HC Jr, McMahan CA, Gidding SS. Preventing heart disease in the 21st century: implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Circulation. 2008; 117(9): 1216-27. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Ozder A. Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study. Lipids Health Dis. 2014; 13: 183. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Nassar PO, Walker CS, Salvador CS, Felipetti FA, Orrico SR, Nassar CA. Lipid profile of people with diabetes mellitus type 2 and periodontal disease. Diabetes Res Clin Pract. 2012; 96(1): 35-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Poznyak A, Grechko AV, Poggio P, Myasoedova VA, Alfieri V, Orekhov AN. The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation. Int J Mol Sci. 2020; 21(5): 1835. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients. Biomark Insights. 2016; 11: 95-104. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Nnakenyi ID, Nnakenyi EF, Parker EJ, Uchendu NO, Anaduaka EG, Ezeanyika LU. Relationship between glycaemic control and lipid profile in type 2 diabetes mellitus patients in a low-resource setting. Pan Afr Med J. 2022; 41: 281. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Kolluru GK, Bir SC, Kevil CG. Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing. Int J Vasc Med. 2012; 2012: 918267. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Anderson KM, Castelli WP, Levy D. Cholesterol and mortality: 30 years of follow up from the Framingham study. Jama. 1987; 257(16): 2176-2180. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Ghari Arab A, Zahedi M, Kazemi Nejad V, Sanagoo A, Azimi M. Correlation between Hemoglobin A1c and Serum Lipid Profile in Type 2 Diabetic Patients Referred to the Diabetes Clinic in Gorgan, Iran. jcbr. 2018; 2 (1): 26-31. [View at Publisher] [DOI] [Google Scholar]
14. Nanaware A, Mankeshwar A. assessment of long term glycemic control (HbA1c) and its correlation with biochemical and other parameters in patients with type 2 diabetes mellitus in an urban community setting. International journal of medical science and public health. 2017; 6(2): 239. [View at Publisher] [DOI] [Google Scholar]
15. Moss Se, Klein R, Klein BE, Muer Sm. The association of glycemia and cause specific mortality in a diabetic population. Archives of internal Medicine . 1994; 154(21): 2473-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
16. Mahajan R, Koley S. Association of HbA1c with lipid profiles in patients with type2 diabeted meliyus. Int J Biomed Res. 2016; 7(3): 239-43. [View at Publisher]
17. Begum A, Irfan S, Hoque M, Habib S, Parvin S, Malek R, et al. Relationship between HbA1c and lipid profile seen in Bangladeshi type 2 diabetes mellitus patients attending Birdem hospital: A cross-sectional study . MMJ. 2018; 28(1): 91-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
18. Parsanassab H, Muradi Paudeh B,Alizadeh A, Abediankenari S. Evaluation of correlation between HbA1c with the risk factors of lipid profile in patients with type diabetes. Journal of Maznderan university of medical sciences. 2012; 21(2): 153-6. [View at Publisher] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Enamad
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.