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1- University of Birjand
2- University ofBirjand ,mogharnasi@birjand.ac.ir
3- hakim sabzavari
2- University ofBirjand ,
3- hakim sabzavari
Abstract: (98 Views)
Background: the aim of the present study is to investigate 10 weeks of combined training on gene expression of nuclear factor κB and sirtuin 1 in fast and slow twitch muscles of aged male rats.
Methods: 16 rats of 24 month were randomly divided into two groups of combined training and control (8 rats in each group). Combined exercises were performed 4 sessions per week (two days of endurance and two days of resistance) in a container with dimensions of 50x50x100 with water at 30±1 degrees Celsius. The data were analyzed by two-way analysis of variance with SPSS version 22 software at the level (P≤0.05). (P≤0.05).
Results: After 10 weeks of combined training, a significant difference was observed between the two training and control groups in gene expression of nuclear factor κB and sirtuin1 (P=0.001 and P=0.001, respectively). The results of the post hoc test showed that there was no significant difference between the gene expression of nuclear factor κB in the fast and slow twitch muscles of the combined training group (P=0.57). Also, no significant difference was observed between sirtuin-1 of the fast-twitch and slow-twitch muscles of the combined training group (P=0.99).
Conclusion According to the results of this research, it is suggested that the elderly can reduce muscle wasting and muscle atrophy by strengthening their muscles by participating in combined exercises in water.
Methods: 16 rats of 24 month were randomly divided into two groups of combined training and control (8 rats in each group). Combined exercises were performed 4 sessions per week (two days of endurance and two days of resistance) in a container with dimensions of 50x50x100 with water at 30±1 degrees Celsius. The data were analyzed by two-way analysis of variance with SPSS version 22 software at the level (P≤0.05). (P≤0.05).
Results: After 10 weeks of combined training, a significant difference was observed between the two training and control groups in gene expression of nuclear factor κB and sirtuin1 (P=0.001 and P=0.001, respectively). The results of the post hoc test showed that there was no significant difference between the gene expression of nuclear factor κB in the fast and slow twitch muscles of the combined training group (P=0.57). Also, no significant difference was observed between sirtuin-1 of the fast-twitch and slow-twitch muscles of the combined training group (P=0.99).
Conclusion According to the results of this research, it is suggested that the elderly can reduce muscle wasting and muscle atrophy by strengthening their muscles by participating in combined exercises in water.
Research Article: Research Article |
Subject:
Sport Physiology
Received: 2023/12/30 | Accepted: 2024/02/21
Received: 2023/12/30 | Accepted: 2024/02/21
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.