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1- GMERS Medical College, Godhra , drpiyushpargi@gmail.com
2- ICMR-National Institute of Traditional Medicine
3- GOVERNMENT MEDICAL COLLEGE, BHAVNAGAR
2- ICMR-National Institute of Traditional Medicine
3- GOVERNMENT MEDICAL COLLEGE, BHAVNAGAR
Abstract: (259 Views)
Background: Anti-diabetic properties of several Ficus species have been explored in animal studies; nevertheless, there is a dearth of research on the hypoglycemic effects of the bark of Ficus Lacor Buch.-Ham. To address this knowledge gap, this study was conducted to assess the hypoglycemic activity of an aqueous extract derived from the bark of Ficus Lacor Buch.-Ham in diabetic rabbits.
Methods: Diabetes was induced in rabbits using alloxan monohydrate (120 mg/kg intravenously). A total of thirty-six rabbits were divided into six groups, each consisting of six animals. The control groups comprised a non-diabetic control group and a diabetic control group. Two test groups, designated as the low-dose and high-dose extract group, received Ficus Lacor extract orally at doses of 100 and 200 mg/kg, respectively, for 6 weeks. Metformin was utilized as an active control group. To evaluate the hypoglycemic effects in normal rabbits, a group of non-diabetic rabbits received Ficus Lacor extract at a dose of 200 mg/kg. Fasting and post-prandial blood sugar levels were monitored on a weekly basis for 6 weeks and subsequently compared. The percentage reduction in blood sugar levels was calculated for each group and compared among the study groups.
Results: At the end of the 6-week, the low-dose Ficus Lacor extract led to an average reduction of 38.3% in FBS and 40.5% in PP2BS, while the high-dose Ficus Lacor extract resulted in an average reduction of 35.3% in FBS and 36.3% in PP2BS.
Conclusion: Aqueous extract of bark of Ficus Lacor demonstrates significant hypoglycemic activity.
Methods: Diabetes was induced in rabbits using alloxan monohydrate (120 mg/kg intravenously). A total of thirty-six rabbits were divided into six groups, each consisting of six animals. The control groups comprised a non-diabetic control group and a diabetic control group. Two test groups, designated as the low-dose and high-dose extract group, received Ficus Lacor extract orally at doses of 100 and 200 mg/kg, respectively, for 6 weeks. Metformin was utilized as an active control group. To evaluate the hypoglycemic effects in normal rabbits, a group of non-diabetic rabbits received Ficus Lacor extract at a dose of 200 mg/kg. Fasting and post-prandial blood sugar levels were monitored on a weekly basis for 6 weeks and subsequently compared. The percentage reduction in blood sugar levels was calculated for each group and compared among the study groups.
Results: At the end of the 6-week, the low-dose Ficus Lacor extract led to an average reduction of 38.3% in FBS and 40.5% in PP2BS, while the high-dose Ficus Lacor extract resulted in an average reduction of 35.3% in FBS and 36.3% in PP2BS.
Conclusion: Aqueous extract of bark of Ficus Lacor demonstrates significant hypoglycemic activity.
Research Article: Original Paper |
Subject:
Biochemistry
Received: 2023/06/21 | Accepted: 2023/11/26
Received: 2023/06/21 | Accepted: 2023/11/26
References
1. Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018; 138: 271-81. [View at Publisher] [DOI] [PMID] [Google Scholar]
2. Classification and Diagnosis of Diabetes. Diabetes Care. 2015; 38(Supplement 1): S8-16. [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Lorenzati B, Zucco C, Miglietta S, Lamberti F, Bruno G. Oral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of Action. Pharmaceuticals. 2010; 3(9): 3005-20. [View at Publisher] [DOI] [PMID] [Google Scholar]
4. Chaudhury A, Duvoor C, Reddy Dendi VS, Kraleti S, Chada A, Ravilla R, et al. Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management. Front Endocrinol (Lausanne). 2017; 8:6. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015; 33(8): 1582-614. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Deepa P, Sowndhararajan K, Kim S, Park SJ. A role of Ficus species in the management of diabetes mellitus: A review. J Ethnopharmacol. 2018; 215:210-32. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Lansky EP, Paavilainen HM, Pawlus AD, Newman RA. Ficus spp. (fig): ethnobotany and potential as anticancer and anti-inflammatory agents. J Ethnopharmacol. 2008; 119(2): 195-213. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Khan MA, Islam MK, Siraj MA, Saha S, Barman AK, Awang K, et al. Ethnomedicinal survey of various communities residing in Garo Hills of Durgapur, Bangladesh. J Ethnobiol Ethnomedicine. 2015; 11(1): 1-46. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Shi Y, Mon AM, Fu Y, Zhang Y, Wang C, Yang X, et al. The genus Ficus (Moraceae) used in diet: Its plant diversity, distribution, traditional uses and ethnopharmacological importance. J Ethnopharmacol. 2018; 226: 185-96. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Irudayaraj SS, Stalin A, Sunil C, Duraipandiyan V, Al-Dhabi NA, Ignacimuthu S. Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats. Chem Biol Interact. 2016; 256: 85-93. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Sharma V, Kumar S, Patel H, Hugar S. Hypoglycemic activity of Ficus Glomerata in alloxan induced diabetic rats. Int J Pharm Sci Rev Res. 2010; 1(2): 18-22. [View at Publisher] [Google Scholar]
12. Rao KS. Acute Oral Toxicity. Biol Eng Med Sci Rep. 2019; 4(2): 39-41. [View at Publisher] [DOI] [Google Scholar]
13. Wang J, Wan R, Mo Y, Zhang Q, Sherwood LC, Chien S. Creating a long-term diabetic rabbit model. Exp Diabetes Res. 2010; 2010: 289614. [View at Publisher] [DOI] [PMID] [Google Scholar]
14. Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008; 51(2): 216-26. [View at Publisher] [DOI] [PMID] [Google Scholar]
15. Pandit R, Phadke A, Jagtap A. Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2010; 128: 462-466. [View at Publisher] [DOI] [PMID] [Google Scholar]
16. Sindhu RK, Arora S. FREE RADICAL SCAVENGING AND ANTIOXIDANT POTENTIAL OF FICUS LACOR BUCH. HUM. Asian J Pharm Clin Res. 2013; 6(9): 184-6. [View at Publisher]
17. Gupta S, Sood S, Singh N, Gupta M. Effect of Neelkanthi (Ajuga bracteosa) and Plakhar(Ficus lacor) on the energy expenditure of diabetic Subjects. Pantnagar J Res India. 2008; 6(2): 286-290. [View at Publisher] [Google Scholar]
18. Ghimire P, Pandey S, Shrestha A. A comprehensive review on phytochemical, pharmacognostical properties and pharmacological activities of Ficus lacor L. (Moraceae). Int J Herb Med. 2020 Aug 18;8:96-102. [View at Publisher] [Google Scholar]
19. Ivorra MD, D'Ocon MP, Paya M, Villar A. Antihyperglycemic and insulin-releasing effects of beta-sitosterol 3-beta-D-glucoside and its aglycone, beta-sitosterol. Arch Int Pharmacodyn Ther. 1988; 296: 224-31. [View at Publisher] [PMID] [Google Scholar]
20. Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutr Metab (Lond). 2015; 12: 60. [View at Publisher] [DOI] [PMID] [Google Scholar]
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