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Serum lactate dehydrogenase (LDH) levels in pregnant women with and without preeclampsia
Roshita Devi Kshetrimayum1 , Ajitkumar Singh Yanglem *2 , Sangeeta Naorem1 , Victoria Kshetrimayum1 , Sunie Laishram1 , Niketa Ashem1
1- RIMS
2- RIMS , ajityanglem40@gmail.com
Abstract:   (43 Views)
Background and objectives: Preeclampsia, a hypertensive disorder of pregnancy affects 10% of pregnancies causing both maternal and foetal complications. It may be associated with complications like visual disturbances, oliguria, eclampsia, hemolysis, elevated liver enzymes, thrombocytopenia, pulmonary edema and fetal growth restriction. Lactate dehydrogenase is an intracellular enzyme and is increased when there is increased cellular death. As preeclampsia leads to cellular death, serum LDH level may reflect the severity of preeclampsia and its level may serve as a guide in the management of the patient.
Methods: This is a cross sectional study, conducted in the Department of Biochemistry in collaboration with the Department of Obstetrics and Gynecology, RIMS, Imphal. The study population consist of 100 participants:50 diagnosed cases of preeclampsia and 50 non preeclamptic women attending RIMS hospital.
Results: The study shows that serum LDH level was significantly higher (p value < 0.05) in preeclamptic women (510.10±184.26)IU in comparison to the pregnant women without preeclampsia (284.38±97.35)IU. Serum LDH levels were found to be positively correlated with increase in blood pressure.
Conclusions: This study shows that serum LDH level is higher in patients with preeclampsia than the non preeclamptic women. LDH level is found to be positively correlated with higher blood pressure. Therefore, detection of serum LDH level may help in detection of preeclampsia so that it may help in close monitoring, prompt and early management of preeclamptic women.
 
Keywords: Pregnancy, Blood pressure, Hypertension
Full-Text [PDF 307 kb]   (11 Downloads)    
Research Article: Research Article | Subject: Biochemistry
Received: 2023/03/14 | Accepted: 2024/09/4
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.