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mljgoums 2023, 17(5): 12-15 |
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Mosavi S, Barari A, Abbassi Daloii A. The effects of a special training program on cytochrome p450 gene expression and reactive oxygen species levels in patients with coronary artery bypass surgery. mljgoums 2023; 17 (5) :12-15
URL: http://mlj.goums.ac.ir/article-1-1336-en.html
URL: http://mlj.goums.ac.ir/article-1-1336-en.html
1- Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
2- Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran ,alireza54.barari@gmail.com
2- Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran ,
Abstract: (1142 Views)
Background: Significant economic consequences can lead to various problems and complications, including medical complications. Coronary artery disease (CAD), a serious health threat with increasing prevalence, is a major cause of death and mortality worldwide. This study aimed to investigate the effects of a special training program on cytochrome P450 (CYP) gene expression and reactive oxygen species (ROS) levels in patients with coronary artery bypass surgery.
Methods: This semi-experimental study was conducted on 16 patients who underwent coronary artery surgery in Babol City, Iran. The patients were selected using a random sampling method and divided into 2 groups: experimental and control groups. The experimental group engaged in an exercise program consisting of 3 sessions per week for a duration of 8 weeks. The expression levels of CYP and ROS genes were measured by the real-time polymerase chain reaction (PCR) method. The analysis was performed by comparing covariances and means.
Results: ROS gene expression levels significantly decreased in the experimental group than in the control group (P=0.003). However, there was no significant difference in P450 levels between the experimental and control groups (P=0.99).
Conclusion: Special exercises reduced ROS expression and increased P450 expression in patients who had coronary bypass surgery. There is a probability that special exercises, can effectively prevent heart damage by increasing antioxidant capacity and reducing ROS.
Methods: This semi-experimental study was conducted on 16 patients who underwent coronary artery surgery in Babol City, Iran. The patients were selected using a random sampling method and divided into 2 groups: experimental and control groups. The experimental group engaged in an exercise program consisting of 3 sessions per week for a duration of 8 weeks. The expression levels of CYP and ROS genes were measured by the real-time polymerase chain reaction (PCR) method. The analysis was performed by comparing covariances and means.
Results: ROS gene expression levels significantly decreased in the experimental group than in the control group (P=0.003). However, there was no significant difference in P450 levels between the experimental and control groups (P=0.99).
Conclusion: Special exercises reduced ROS expression and increased P450 expression in patients who had coronary bypass surgery. There is a probability that special exercises, can effectively prevent heart damage by increasing antioxidant capacity and reducing ROS.
Research Article: Original Paper |
Subject:
Sport Physiology
Received: 2020/10/1 | Accepted: 2021/05/15 | Published: 2024/01/15 | ePublished: 2024/01/15
Received: 2020/10/1 | Accepted: 2021/05/15 | Published: 2024/01/15 | ePublished: 2024/01/15
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