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mljgoums 2021, 15(4): 15-20 |
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Hamta A, Hosseinpour M, Komijani M. Association of Interleukin-16 Gene Polymorphisms rs11556218 T/G and rs4072111 C/T with Risk of Breast Cancer in an Iranian Population. mljgoums 2021; 15 (4) :15-20
URL: http://mlj.goums.ac.ir/article-1-1311-en.html
URL: http://mlj.goums.ac.ir/article-1-1311-en.html
1- Department of Biology, Faculty of Sciences, Arak University , a-hamta@araku.aC.IR
2- Department of Biology, Faculty of Sciences, Arak University
2- Department of Biology, Faculty of Sciences, Arak University
Abstract: (2512 Views)
Background and objectives: Breast cancer is the leading cause of death in women. Cytokines regulate the intensity and continuity of immune response by balancing cell-mediated immunity and humoral responses. This study aimed to investigate the relationship between two polymorphisms of the interleukin-16 (IL-16) gene and risk of breast cancer.
Methods: Blood samples were collected from 80 breast cancer patients and 80 healthy individuals. Polymorphisms rs11556218 T/G and rs4072111 C/T were investigated by polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR). Then, genotype and allele frequency distributions were evaluated in each group using the SPSS software (version 24).
Results: The frequency of genotype rs11556218 differed significantly between the patients and controls (P=0.007). The TG genotype (odds ratio [OR]= 2.471, 95% confidence intervals [CI]: 1.229-4.965, P= 0.001) and total TG+GG genotypes (OR= 3.095, 95% CI: 1.624-5.899, P= 0.001) had a significant relationship with increased risk for breast cancer. The allele and genotype frequencies of rs4072111 C/T polymorphism did not differ significantly between the patients and controls.
Conclusion: Our findings suggest that the rs11556218 T/G polymorphism of the IL-16 gene may be associated with susceptibility to breast cancer.
Research Article: Original Paper |
Subject:
Human Genetics
Received: 2020/08/17 | Accepted: 2021/03/1 | Published: 2021/06/30 | ePublished: 2021/06/30
Received: 2020/08/17 | Accepted: 2021/03/1 | Published: 2021/06/30 | ePublished: 2021/06/30
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.