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mljgoums 2020, 14(5): 42-47 |
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Hejazi S M, Hosseni Abrishami L. Changes in Some Inflammatory Indices in Men with Heart Failure after Eight Weeks of Continuous and Intermittent Aerobic Exercise. mljgoums 2020; 14 (5) :42-47
URL: http://mlj.goums.ac.ir/article-1-1240-en.html
URL: http://mlj.goums.ac.ir/article-1-1240-en.html
1- Lecturer, Department of physical education, khayyam University, Mashhad, Iran.
2- Lecturer, Department of physical education, khayyam University, Mashhad, Iran. ,ladan.abrishami@gmail.com
2- Lecturer, Department of physical education, khayyam University, Mashhad, Iran. ,
Abstract: (2981 Views)
Background and objectives: Evidence has shown that inflammatory mediators play an important role in the pathogenesis of atherosclerosis. The aim of this study was to evaluate effects of eight weeks of continuous and intermittent aerobic exercise on some inflammatory indices in men with heart failure.
Methods: The effects of continuous aerobic exercise (at 45-70% maximum heart rate) and intermittent aerobic exercise (at 45-80% of maximum heart rate) on the level of interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor alpha (TNFα) were evaluated in 42 men with heart failure using commercial ELISA kits. Blood samples were taken after 12 hours of fasting one hour before the first session and 48 hours after the last exercise session. The subjects performed exercises three sessions a week, for eight weeks. Data were analyzed by one-way ANOVA at significance of 0.05.
Results: After the exercise program, serum hs-CRP (P=0.023), IL-6 (P=0.018) and TNF-α (P=0.048) differed significantly between the exercise groups and the control group. In addition, serum levels of IL-6 and hs-CRP decreased slightly in the intermittent aerobic group, but there was no significant difference between the two exercise groups. Intermittent aerobic exercise significantly reduced serum TNF-α level compared to the control group.
Conclusion: Probably aerobic exercise can have positive effects on the level of hs-CRP, IL-6 and TNF-α in patients with heart failure.
Methods: The effects of continuous aerobic exercise (at 45-70% maximum heart rate) and intermittent aerobic exercise (at 45-80% of maximum heart rate) on the level of interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor alpha (TNFα) were evaluated in 42 men with heart failure using commercial ELISA kits. Blood samples were taken after 12 hours of fasting one hour before the first session and 48 hours after the last exercise session. The subjects performed exercises three sessions a week, for eight weeks. Data were analyzed by one-way ANOVA at significance of 0.05.
Results: After the exercise program, serum hs-CRP (P=0.023), IL-6 (P=0.018) and TNF-α (P=0.048) differed significantly between the exercise groups and the control group. In addition, serum levels of IL-6 and hs-CRP decreased slightly in the intermittent aerobic group, but there was no significant difference between the two exercise groups. Intermittent aerobic exercise significantly reduced serum TNF-α level compared to the control group.
Conclusion: Probably aerobic exercise can have positive effects on the level of hs-CRP, IL-6 and TNF-α in patients with heart failure.
Research Article: Original Paper |
Subject:
Sport Physiology
Received: 2019/08/17 | Accepted: 2019/12/11 | Published: 2020/08/24 | ePublished: 2020/08/24
Received: 2019/08/17 | Accepted: 2019/12/11 | Published: 2020/08/24 | ePublished: 2020/08/24
References
1. Mendis S, Puska P, Norrving B. Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization. 2011; 12-35.
2. Boettger S, Müller HJ, Oswald K, Puta C, Donath L, Gabriel HH, et al. Inflammatory Changes upon a Single Maximal Exercise Test in Depressed Patients and Healthy Controls. Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34(3): 475-8. doi:10.1016/j. pnpbp. 2010.01.016. [DOI:10.1016/j.pnpbp.2010.01.016]
3. Hejazi SM, Hosseni Abrishami L, Mohammad Khani J, Boghrabadi V. The Effect of 8 Week Aerobic Exercises on Serum Levels of Cell Adhesion Molecules among Middle-aged Women. Advanced Studies in Biology. 2013; 5(6): 279-289. doi:10.12988/asb.2013.3210 [DOI:10.12988/asb.2013.3210]
4. Van Kimmenade RR, Januzzi JL. Emerging Biomarkers in Heart Failure. Clinical Chemistry. 2012; 58(1): 127-38. doi:10.1373/clinchem.2011.165720. [DOI:10.1373/clinchem.2011.165720]
5. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. Meta-Analysis of Cytokines in Major Depression. Biol Psychiatry. 2010; 67 (5): 446-457. doi:10.1016/j.biopsych.2009.09.033. [DOI:10.1016/j.biopsych.2009.09.033]
6. Csiszar A, Ungvari Z. Synergistic Effects of Vascular IL-17 and TNFalpha may Promote Coronary Artery Disease. Med Hypotheses. 2004; 63(4): 696-8. doi:10.1016/j.mehy.2004.03.009. [DOI:10.1016/j.mehy.2004.03.009]
7. Satti HS, Hussain S, Javed Q. Association of Interleukin-6 Gene Promoter Polymorphism with Coronary Artery Disease in Pakistani Families. ScientificWorldJournal. 2013; 2013: 538365. doi: 10.1155/2013/538365. [DOI:10.1155/2013/538365]
8. Tsimikas S, Duff GW, Berger PB, Rogus J, Huttner K, Clopton P, et al. Pro-Inflammatory Interleukin-1 Genotypes Potentiate the Risk of Coronary Artery Disease and Cardiovascular Events Mediated by Oxidized Phospholipids and Lipoprotein(a). J Am Coll Cardiol. 2014; 63(17): 1724-34. doi:10.1016/j.jacc.2013.12.030. [DOI:10.1016/j.jacc.2013.12.030]
9. Zgraggen L, Fischer JE, Mischler K, Preckel D, Kudielka BM, Von Känel R. Relationship Between Hemoconcentration and Blood Coagulation Responses to Acute Mental Stress. Thromb Res. 2005; 115(3): 175-83. doi:10.1016/j.thromres.2004.08.022. [DOI:10.1016/j.thromres.2004.08.022]
10. Signorelli SS, Mazzarino MC, Di Pino L, Malaponte G, Porto C, Pennisi G, et al. High Circulating Levels of Cytokines (IL-6 and TNFalpha), Adhesion Molecules (VCAM-1 and ICAM-1) and Selectins in Patients with Peripheral Arterial Disease at Rest and after a Treadmill Test. Vasc Med. 2003; 8(1): 15-19. doi:10.1191/1358863x03vm466oa. [DOI:10.1191/1358863x03vm466oa]
11. Michowitz Y, Arbel Y, Wexler D, Sheps D, Rogowski O, Shapira I, et al. Predictive Value of High Sensitivity CRP in Patients with Diastolic Heart Failure. Int J of Cardiology. 2008; 125: 347-351. doi:10.1016/j.ijcard.2007.02.037. [DOI:10.1016/j.ijcard.2007.02.037]
12. Wilund KR. Is the Anti-Inflammatory Effect of Regular Exercise Responsible for Reduced Cardiovascular Disease? Clin Sci (Lond). 2007; 112(11): 543-55. doi:10.1042/CS20060368. [DOI:10.1042/CS20060368]
13. Witkowska AM. Soluble ICAM-1: A Marker of Vascular Inflammation and Lifestyle. Cytokine. 2005; 31(2): 127-34. doi:10.1016/j.cyto.2005.04.007. [DOI:10.1016/j.cyto.2005.04.007]
14. Pearson MJ, Mungovan SF, Smart NA. Effect of Aerobic and Resistance Training on Inflammatory Markers in Heart Failure Patients: Systematic Review and Meta-Analysis. Heart Failure Reviews. 2018; 23(2): 209-223. doi:10.1007/s10741-018-9677-0. [DOI:10.1007/s10741-018-9677-0]
15. Friedenreich CM, O'Reilly R, Shaw E, Stanczyk FZ, Yasui Y, Brenner DR, et al. Inflammatory Marker Changes in Postmenopausal Women after a Year-Long Exercise Intervention Comparing High Versus Moderate Volumes. Cancer Prevention Research. 2016; 9(2): 196-203. doi:10.1158/1940-6207.CAPR-15-0284. [DOI:10.1158/1940-6207.CAPR-15-0284]
16. Jakicic JM, Wing RR, Butler BA, Robertson RJ. Prescribing Exercise in Multiple Short Bouts Versus one Continuous Bout: Effects on Adherence, Cardiorespiratory Fitness, and Weight Loss in Overweight Women. Int J Obes Relat Metab Disord. 1995; 19(12): 893-901.
17. Pate RR, Pratt M, Blair SN, Haskell WL, Macera CA, Bouchard C, et al. Physical Activity and Public Health. A Recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA. 1995; 273(5): 402-7. doi:10.1001/jama.273.5.402. [DOI:10.1001/jama.273.5.402]
18. AACVPR. Cardiac Rehabilitation Resource Manual. Chicago, IL. Human Kinetics. 2006; 142-147.
19. Hammonds TL, Gathright EC, Goldstein CM, Penn MS, Hughes JW. Effects of Exercise on C-Reactive Protein in Healthy Patients and in Patients with Heart Disease: A Meta-Analysis. Heart Lung. 2016; 45(3): 273-82. doi:10.1016/j.hrtlng.2016.01.009. [DOI:10.1016/j.hrtlng.2016.01.009]
20. Tenorio TRS, Balagopal PB, Andersen LB, Ritti-Dias RM, Hill JO, Lofrano-Prado MC, et al. Effect of Low vs. High Intensity Exercise Training on Biomarkers of Inflammation and Endothelial Dysfunction in Adolescents with Obesity: A 6-Month Randomized Exercise Intervention Study. Pediatr Exerc Sci. 2018; 30(1): 96-105. doi: 10.1123/pes.2017-0067. [DOI:10.1123/pes.2017-0067]
21. Kim ES, Im JA, Kim K, Park H, Suh S, Kang E. Improved Insulin Sensitivity and Adiponectin Level After Exercise Training in Obese Korean Youth. Obesity (Silver Spring). 2007; 15(12): 3023-30. doi: 10.1038/oby.2007.360. [DOI:10.1038/oby.2007.360]
22. Haghir H, Hejazi S M, Minaee S. Changes of Serum Intercellular Adhesion Molecule - 1, Vascular Adhesion Molecule-1 and C - Reactive Protein in Middle-Aged Men with Heart Failure after Eight Weeks of Aerobic Exercise. JSSU. 2017; 24(12): 1013-1023.
23. Bijeh N, Hejazi K. The Effect of Aerobic Exercise on Levels of HS-CRP, Insulin Resistance Index and Lipid Profile in Untrained Middle-aged Women. RJMS. 2018; 24 (163): 1-11.
24. Keating SE, Machan EA, O'Connor HT, Gerofi JA, Sainsbury A, Caterson ID, et al. Continuous Exercise but not High Intensity Interval Training Improves Fat distribution in Overweight Adults. J Obes. 2014; 2014: 834865. doi: 10.1155/2014/834865. DOI:10.1155/2014/834865. [DOI:10.1155/2014/834865]
25. Mattusch F, Dufaux B, Heine O, Mertens I, Rost R. Reduction of the Plasma Concentration of C-Reactive Protein Fllowing Nine Months of Endurance Training. Int J sports Med. 2000; 21: 21-24. doi:10.1055/s-2000-8852. [DOI:10.1055/s-2000-8852]
26. Lakka TA, Laaksonen DE. PhysicalAactivity in Prevention and Ttreatment of the Metabolic Syndrome. Appl Physiol Nutr Metab. 2007; 32(1): 76-88. doi:10.1139/h06-113. [DOI:10.1139/h06-113]
27. Nicklas BJ, You T, Pahor M. Behavioural Treatments for Chronic Systemic Inflammation: Effects of Dietary Weight Loss and Exercise Training. CMAJ. 2005; 172(9): 1199-209. doi:10.1503/cmaj.1040769. [DOI:10.1503/cmaj.1040769]
28. Leick L, Lindegaard B, Stensvold D, Plomgaard P, Saltin B, Pilegaard H. Adipose Tissue Interleukin-18 mRNA and Plasma Interleukin 18: Effect of Obesity and Exercise. Obesity. 2007; 15(2): 356-63. doi:10.1038/oby.2007.528. [DOI:10.1038/oby.2007.528]
29. Abedi B. The Effects of 12-wk Combined Aerobic/Resistance Ttraining on C-Reactive Protein (CRP) Serum and Interleukin-6 (IL-6) Plasma in Sedentary Men. Yafte. 2012; 14(4): 95-106. [Persian]
30. Balducci S, Zanuso A, Nicolucci F, Fernando S. Cavllo S, Fallucca E, et al. Anti-inflammatory Effect of Exercise Training in Subjects with Type 2 Diabetes and the Metabolic Syndrome is Dependent on Exercise Modalities and Independent of Weight Loss. Nutr METAB Cardiovasc Dis. 2010; 20(8): 608-17. doi:10.1016/j.numecd.2009.04.015. [DOI:10.1016/j.numecd.2009.04.015]
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