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younesian O, younesian S, hosseinzadeh S, joshaghani H R. Association of Selenium and Risk of Esophageal Cancer: A Review. mljgoums 2020; 14 (1) :1-9
URL: http://mlj.goums.ac.ir/article-1-1232-en.html
URL: http://mlj.goums.ac.ir/article-1-1232-en.html
1- Metabolic disorders research center, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of hematology and blood banking Department of Hematology and Blood Banking, Tehran University of Medical Sciences, Tehran, Iran
3- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
4- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,joshaghani@goums.ac.ir
2- Department of hematology and blood banking Department of Hematology and Blood Banking, Tehran University of Medical Sciences, Tehran, Iran
3- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
4- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (4085 Views)
ABSTRACT
Esophageal cancer (EC) is one of the most common types of cancer, especially in Asia. Esophageal squamous cell cancer (ESCC) is the most important histological subtype of EC, which accounts for 90% of all EC cases worldwide. ESCC is highly prevalent in Turkey, Iran, Kazakhstan and northern and central parts of China. Selenium is an essential micronutrient that is required for cellular functioning and synthesis of several selenoproteins. It also modulates the antioxidant defense system, cell cycle and apoptosis. This article reviews the most important molecular mechanisms of EC and investigates the association between selenium level and incidence of EC in high-risk areas.
Keywords: Esophageal cancer, selenium, selenoprotein.
Esophageal cancer (EC) is one of the most common types of cancer, especially in Asia. Esophageal squamous cell cancer (ESCC) is the most important histological subtype of EC, which accounts for 90% of all EC cases worldwide. ESCC is highly prevalent in Turkey, Iran, Kazakhstan and northern and central parts of China. Selenium is an essential micronutrient that is required for cellular functioning and synthesis of several selenoproteins. It also modulates the antioxidant defense system, cell cycle and apoptosis. This article reviews the most important molecular mechanisms of EC and investigates the association between selenium level and incidence of EC in high-risk areas.
Keywords: Esophageal cancer, selenium, selenoprotein.
Research Article: Review Article |
Subject:
Biochemistry
Received: 2019/07/18 | Accepted: 2019/08/19 | Published: 2019/10/30 | ePublished: 2019/10/30
Received: 2019/07/18 | Accepted: 2019/08/19 | Published: 2019/10/30 | ePublished: 2019/10/30
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