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mljgoums 2023, 17(5): 20-22 |
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Ramezani N, Dezhan M, Khalili S S, Shakeri N, Khoramipour K. Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats. mljgoums 2023; 17 (5) :20-22
URL: http://mlj.goums.ac.ir/article-1-1173-en.html
URL: http://mlj.goums.ac.ir/article-1-1173-en.html
1- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, University of Tehran, Tehran, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Center Tehran Branch, Tehran, Iran
3- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Saveh Branch, Saveh, Iran
4- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Olum Tahghighat Branch, Tehran, Iran.
5- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, University of Tehran, Tehran, Iran ,k.khoramipour@gmail.com
2- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Center Tehran Branch, Tehran, Iran
3- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Saveh Branch, Saveh, Iran
4- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Olum Tahghighat Branch, Tehran, Iran.
5- Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, University of Tehran, Tehran, Iran ,
Abstract: (1185 Views)
Background: Omentin-1 plays an important role in insulin function. Despite numerous studies, the effect of interval training on this adipokine is still vague. This study aimed to elucidate the effect of high-intensity interval training (HIIT) on serum glucose, insulin, insulin resistance (IR), omentin-1 serum levels, and gene expression in the visceral adipose tissue in type 2 diabetic (T2D) rats.
Methods: In an experimental study, 20 male rats (8-10 weeks, weight: 250-270 g) were randomly divided into 2 groups: diabetic control (N=10) and diabetic training (N=10). The training protocol was 30 minutes of HIIT (1-min run, 2-min rest) performed 5 days a week for 4 weeks. Fasting blood glucose, insulin resistance, omentin-1 serum level, and gene expression were measured in the visceral fat 48 hours after the last exercise for both groups.
Results: The HIIT resulted in lower serum glucose and insulin resistance (P = 0.001), higher serum omentin-1 levels (P = 0.001), and higher visceral fat gene expression (P = 0.004) in the training group compared to the control group.
Conclusion: Lower serum glucose and insulin resistance and higher omentin-1 serum levels and gene expression in the training group can prove the effectiveness of HIIT training in T2D, although further research is required.
Research Article: Original Paper |
Subject:
Sport Physiology
Received: 2019/01/10 | Accepted: 2019/05/12 | Published: 2024/01/15 | ePublished: 2024/01/15
Received: 2019/01/10 | Accepted: 2019/05/12 | Published: 2024/01/15 | ePublished: 2024/01/15
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