Background and Objective: The infection of
Helicobacter pylori (H. pylori) is one of the most complex items addressed in the clinical microbiology. Although
H. pylori positive subjects are bound to develop into atrophic gastritis, current body of evidences is rare. Due to the high prevalence of this bacterium worldwide, finding the true virulence factors as biomarkers for severe gastroduodenal diseases was the priority in recent researches. This study was carried out to determine the prevalancy of
cagA and
babA of
Helicobacter pylori isolated from gastric atrophic patients.
Methods: This descriptive – analytical study was conducted on 100 patients with gastroduodenal disorders in Labafinejad hospital in Tehran, Iran during 2018. Identification of each patient and also bacterial isolation were undertaken according to the standard protocols.
Results: H. pylori were isolated in 23% of patients. 10 patients affected by atrophic gastritis followd by gastric ulcer (7 patients) and acute gastritis (6 patients). In totally, the rate of cagA gene and
babA in
H. pylori isolated with positive results was 52% and 34%, respectively. There was a significant association between the presence of
cagA positive strains and patients with gastric atrophic (P<0.05). The
babA gene did not correlate with the presence of gastric atrophic patients.
Conclusion: This study showed that various carrying
cagA positive
H. pylori can be recovered from patients with gastric atrophy.
