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Background and Objective: In pathogenesis of beta major thalassemia, tissue damage is occurring due to oxidative stress. The present study was designed to evaluate the effects of vitamin E supplementation on serum Paraoxonase, SOD, GPX enzyme activity and lipid profiles in beta major thalassemia patients. Materials and Methods: In this clinical tiral study, Sixty (25 males, 35 females) beta major thalassemia patients with age≥18 years who had criterias to enter the study, were selected randomely in two groups. The patients in interventional group, vitamin E at a dose of 400 mg/day were given for three months, with no supplementations in control group. The enzyme activities of paraoxonase, SOD, GPX and lipid profiles (LDL-c, HDL-c, triglyceride, total Antixidant Capacity) were measured prior and after 3 months in both case and control groups. Data analyzed by using paired t-test. Results: Significant increases in serum levels of vitamin E, Paraoxonase activity, HDL cholesterol (P<0.001), BMI (P≤0.001) and a significant reduction in GPX activity (P<0.05) were observed in cases compared to controls. Conclusion: The vitamin E supplementation may be useful in reducing oxidative stress and lipid profiles in beta major thalassemic patients.

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Background and Objective: An activity performed through a new motional pattern and very intensively often leads to a kind of muscle soreness whose indicator is delayed onset of pain, which is called Delayed Onset Muscle Soreness (DOMS). This study was done to determine the effect of vitamin C and E supplementation on lipid peroxidation and delayed onset muscle soreness in professional basketball players. Methods: In this clinical trial study, 24 male professional basketball players were randomly divided into four groups including vitamin C (1000 mg), vitamin E (800 IU), vitamin C (500 mg) + vitamin E (400 IU) and placebo (Glucose 500 mg). Supplement was consumed two hours before and 24 hours after leg press and scuat exercise. Blood samples were collected before the first supplementation and immediately (post- exercise), 24 hour and 48 hour after exercises. Serum creatine kinase (CK), malondialdehyde (MDA), vitamin C and vitamin E and the level of perceived muscle soreness were evaluated. Results: MDA in Vitamin E group significantly decreased in the 24-hr to 48-hr after the exercise in compared to bignning of exercise (P<0.05). Serum CK significantly increased 24-hr and 48-hr after the exercise in all groups (P<0.05). Muscle pain perception non significantly increased after the exercise in all groups in compare to baseline level. Conclusion: Short period supplementationin of vitamin C and E, either alone or in combination can not reduce pain and muscle damage and lipid peroxidation following the leg press and scuat exercise in professional basketball players.

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Background and Objective: Para-nonylphen as an environmental pollutant has weak estrogenic activity and causes oxidative stress in different organs including testis. This study was done to determine the protective effect of vitamin E on the para-nonylphenol induced-testicular toxicity in adult rats. Methods: In this experimental study, 24 Wistar rats were randomly allocated into four groups including control, vitamin E (100 mg/kg/day, orally), para-nonylphenol (250mg/kg/day, orally) and finally para-nonylphenol (250mg/kg/day, orally) plus vitamin E (100mg/kg/day, orally). After 56 days of treatment, removal of the right testis, tissue processing and staining with Heidenhain's Azan, the morphometric parameters of testicular tissue was evaluated using stereological method. Results: The mean volume of seminiferous tubules, height of the germinal epithelium, seminiferous tubules diameter, thickness of the basement membrane, number of spermatocyte, spermatid and sertoli cells significantly reduced in para nonylphenol group compared to the controls (P<0.05). These parameters were significantly increased in the para-nonylphenol plus vitamin E group compared to para nonylphenol group (P<0.05). In the histopathological examination, atrophy of seminiferous tubules, germinal epithelium vacuolation and epithelial disarrangement were observed in para nonylphenol group. Histopathological alterations reduced in para-nonylphenol plus vitamin E group compared to para nonylphenol group. Conclusion: Co-administration of vitamin E with para nonylphenol can prevent the adverse effects of para nonylphenol on the testicular tissue in adult rats.

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Background and Objective: Herbal products consumption is increased worldwide. This study was done to compare the effect of Evening Primrose, Vitex agnus and vitamin E on premenstrual syndrome. Methods: In this clinical trials study, 210 women with premenstrual syndrome were randomly divided eqaly into Evening Primrose (500 mg, 3 times per day), Vitex agnus (40 mg/day) and vitamin E (400 Iu/day) groups. The subjects were received the thraputic regiment for 2 months. Severity of premenstrual syndrome was recorded for each subject using DSR Dickerson questinare, perior and at the end of intervention. Results: After intervention, severity of premenstrual syndrome was reduced in Evening Primrose group (60.58±30.6 to 34.09±19.81), Vitex agnus (61.23±30.54 to 25.25±17.78) and the vitamin E group, (61.24±32.04 to 54.9±19.24). Severity of premenstrual syndrome were reduced in the Evening Primrose and Vitex agnus groups in compared to vitamin E group (P<0.05). Severity of premenstrual syndrome were reduced in Vitex agnus in comparision with Evening Primrose (P<0.05). Conclusion: Vitex agnus, Evening Primrose and vitamin E can reduce severity of premenstrual syndrome, but therapeutic effect of Vitex agnus is more than Evening Primrose and vitamin E.

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Background and Objective: Sodium meta-bisulphite is used as a preservative in food and pharmaceutical industries. The aim of this study was to determine the effect of vitamin E on the improvement of sodium-meta bisulphite-induced complications on ovarian tissue and sex hormones in rats.
Methods: In this experimental study, 70 adult Wistar rats were randomly allocated into 7 groups including control, sham and interventional groups were received vitamin E (200 mg/kg/bw), sodium metabisulfite (520 mg/kg/bw), and sodium meta-bisulphite (520 mg/kg/bw) was combined with vitamin E in 50, 100 and 200 mg/kg/bw doses. Prescriptions were taken as gavage for 30 days. Blood samples were taken from animals to measure LH, FSH, estrogen and progesterone hormones. Ovaries were removed and follicles were counted after tissue sections.
Results: The concentration of estrogen hormones, progesterone, LH, FSH and number of ovarian follicles in the groups receiving sodium meta-bisulphite and vitamin E alone was significantly lower than control group (P<0.05). In animals treated with sodium meta-bisulphite and vitamin E at 100 and 200 mg/kg/bw, no significant difference was observed. However, in animals which were simultaneously treated with meta-bi-sulfite sodium and vitamin E at dose 100 and 200 mg/kg, in compared with the control group, significant improvement was not observed.
Conclusion: Sodium meta-bisulphite consumption with 50, 100 and 200 mg/kg body weight of vitamin E can reduce the effect of sodium meta-bisulphite on ovarian follicles and sex hormones.