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Background and Objective: Oxidative stress is known as the one of the causes of neuropathic pain, reactive oxygen species (ROS) has been reported to be involved in this process. Coenzyme Q10 acts as an antioxidant and is able to reduce resulting oxidative damage. This study was done to determine the effect of Coenzyme Q10 on neuropathic pain in CCI (Chronic Crash Injury) rat model.

Materials and Methods: In this experimental study 30 male rats (200-250g) randomizely allocated into 3 groups each 10 rat including CCI, CCI + CoQ10 and CCI + vehicle. Neuropathic pain, was induced by Chronic Crash Injury (CCI) model for sciatic nerve. IP injection of CoQ10 (200 mg/kg) or vehicle was done daily for 10 days. Behavioral tests were done before and after surgery on day 5 and 10 respectively. Paw withdrawal threshold was assessed by Randall Selitto test, Analgesy Metter and Von Frey filaments. Data was analyzed by SPSS-14, Independent T and Mean-whatney tests.

Results: Induction of nerve injury decreased pain threshold (P<0.05) and treatment with CoQ10 increased mechanical and thermal threshold in neuropathic rats compared to CCI animals (P<0.05). There was a significant difference in pain threshold between animals treated CoQ10 and vehicle injected animals (P<0.05).

Conclusion: This study indicated that coenzyme Q10 prevents deleterious effects following nerve injury in animal model.

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Background and Objective: Extensive exercise may be disrupting oxidant and antioxidant balance and cause the phenomenon of oxidative stress in human and decrease athletics performance. This study was done to determine the effect of coenzyme Q10 supplementation for two weeks on markers of lipid peroxidation in soccer player. Methods: In this queze – experimental study, 36 soccer players (mean age, 20.08±1.12 years, weight 63.28±1.65 kg and maximal oxygen uptake 53.12±0.98 ml per kg/bw) divided into three groups for 14 days and the desired experiment was done during this period of time. Soccer players in control group did not receive the supplements and exercise. Subjects in placebo group were received 5 mg/kg/bw aspartame capsules. Subjects in supplement group were received 5 mg/kg/bw of Ubiquinone-10. Soccer players also performed two 90-minute soccer matches with less than 48 hours. Blood samples 24 hours before and after the period were collected. Malondialdehyde (MDA), lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate aminotransferase (AST) levels were measured. Results: Serum level of MDA and AST after two consecutive football matches was significantly increased in the placebo group in compared to supplementation and placebo groups (P<0.05). The serum levels of AST and MDA in supplementation group did not significantly increased when compared to control and placebo groups. Conclusion: Short-term supplementation of coenzyme Q10 before and during of the two consecutive soccer matches can prevent the elevation of lipid Peroxidation indeces.