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Showing 31 results for Tuberculosis

Ghaemi E (phd), Ghazi Saedi K (phd), Babai M (bsc),
Volume 1, Issue 2 (6-1999)

We studied the effect of different concentration of streptomycin in growth of Mycobacterium Tuberculosis strains. The results showed that in Streptomycin resistant and sensitive strains addition of 0.1 µg/ml and 0.01 µg/ml of Streptomycin in Lowenstein media, enhanced the appearance of colony about 5-7 and 1-5 days respectively. This observation may be due to the effect of Streptomycin on porin proteins of Mycobacterium Tuberculosis cell wall. Strains of M.tub showed modified colony morphology in the presence of low concentration of Streptomycin (0.1 & 0.01 µg/ml).
A.a.eimani –e-Fooladi (m.sc), M.sattari (ph .d), K .ghzi – Saedi (ph .d),
Volume 3, Issue 2 (9-2001)

The appearance of the Tuberculosis drug resistance caused to expand the research about the new drugs. LSJ medium used as a main base for culturing the Mycobacterium Tuberculosis in most place of the world. A group of the anti-microbial substance which are used to treat the Tuberculosis are sensitive to heat and they can not be used in LSJ medium. In the performed research by considering the primary possibilities in each Tuberculosis research laboratory a method designed used for the drug resistance. In this method the using of the drugs for treatment of Tuberculosis examined and it was compared with the standard method. The primary contact in the 48 hours of the Mycobacterium in middle broke 7H9 broth showed the same results as the middle broke 7H10 Agar culture.
E.ghaemi (ph.d), K. Ghazisaidei (ph.d), H.kohsarei (m.sc), B.khodabakhshei (m.d), F.kohsar (m.sc), N.behnampour (m.sc), M.basorei (b.sc), M.babaei-Kochaksaraei (b.sc), Sh.bahmanyar (m.d),
Volume 4, Issue 2 (9-2002)

All the different kind of Mycobacterium species except Tuberculosis Leprae and Bovis are considered as environmental Mycobacterium, which usually can be isolated from sand, water and dusts. In addition to the role of their pathogenesis, they can stimulate the immune systems. The immune mechanisms following Mycobacterium environmental contamination can be either protect or destroy the immune system when facing the disease related to the Mycobacterium. The Golestan province has got 2 regions from the point of view of TB epidemy, it is higher in the east. The aim of this project is determine the prevalency of various types and strains of environmental Mycobacterium in the east and west of the region. The samples were collected from both regions from the wet sand, and muddes covered with grass and following their preparation they were cultured on the Lowen Stein Jenson. The total of samples were 220 from these 120 samples were from the region with epidemy of TB out of these we had 25 samples with positive culture (20.8%) and 47 type of mycobacterium were isolated, the most common forms of them were Mycobacterium Fortuitum (34%), Mycobacterium Flavesens (21.2%), Mycobacterium Chelonae (12.8%). From 100 samples taken from the region with low epidemy of TB 66 samples were with positive culture (66%) which 114 strains of Mycobacterium were diagnosed. The most common forms of these microorganisms were Mycobacterium Flavesens (20.1%), Mycobacterium Chelonae (18.4%) and Mycobacterium (16.6%). In conclusion in all the Golestan province without taking notice the TB epidemy form 220 samples 91% were positive culture (41.2%) which 161 different strains were diagnosed out of these the most common were Mycobacterium Fortuitum (21.8%), Mycobacterium Flavesens (20.5%) and Mycobacterium Chelonae (16.8%). The epidemy and variousity of environmental Mycobacterium in the region with low epidemy were much higher than the region with high epidemy and in regard to that these differences are due to the bioenvironmental factors. So therefore this can indicate that the possibility of higher contact between the immune systems and the environmental Mycobacterium. These Mycobacteriums can act as Booster of BCG vaccine which can continuously stimulate the immune systems and this can help the body’s proper responses when facing with the TB Mycobacterium.
E.ghaemi (ph.d), K. Ghazisaidei (ph.d),
Volume 4, Issue 2 (9-2002)

Mycobacterial diseases are among the oldest disease known to human beings. There are a lot of bitter memories of Mycobacterial invasion especially Tuberculosis and leprosy in human mind, even now after discovery of etiology, diagnostic tool, prevention, and treatment, still, the recalling the above diseases are frightening to human being. Although leprosy isn’t an serious disease nowadays but the TB after a long period of quietness, is going to be an serious risk factor for mankind, especially in third world countries, after cooperating with HIV. Some atypical Mycobacteria, which have weak pathogenicity now, adapt themselves to the new condition and present as a dangerous cause of disease. The researcher that have made themselves familiar with such Mycobacterial features, trying hard to discus carefully the specifities and weak points of these bacteria, to fight them back. The aim of this review article is to highlight one of Mycobacterial characteristic, which is bacteruosis slow growth rate.
A.abassi (m.d), M.aarabi (m.d),
Volume 6, Issue 1 (3-2004)

Background & Objective: About 1.3 billions people are infected with Tuberculosis (TB) all over the world. There is a close relationship between the quality of TB treatment and the rate of drug resistance. The recurrence epidemy of TB and increased resistance to some drugs was the basis for the WHO to suggest the directly observed short course treatment strategy or (DOTS) strategy, for the TB patients. Materials & Methods: This research was a cohort study and aimed to evaluate the epidemiological finding, the clinical basis and strategy of DOTS on improving, and prevention from failure of treatment and was compared with non-DOTS procedure. Sample population were total of 260 smear positive patients that had been under study for a period of 2 years (1999-2000). All of the patients were new cases. SPSS software and Fisher exact test was used to analyzed the data. Results: The rate of treatment failure in DOTS strategy in the beginning of 5th month was 1.7%, but in the control group the failure in the same period was 7.3% (P<0.05). Conclusion: This study indicated that the DOTS strategy is substantially increasing the success rate of TB treatment.
E.shafigh (m.d), S.siadati (m.d),
Volume 6, Issue 2 (9-2004)

Background & Objective: Tuberculosis (TB) is still one of the most common causes of death in the world. The incidence of TB, included extra pulmonary variant has been increasing in developed countries for 2 past decades and also has a high incidence and prevalence in underdeveloped countries. To determine the type of involved organ by extra pleuro-pulmonary TB in Shahid Beheshti Hospital in Babol, the present study was carried out. Materials & Methods: Pathological reports of extra pleuro-pulmonary TB in Babol Shahid Beheshti Hospital during performed 1990-2003 have been studied. Sex, age and involved organs were determined, and subsequently the appropriate table was set up. Results: During 14 years, we diagnosed 82 cases of extra pleuro-pulmonary TB, 44 were men and 38 women, with age ranges of 8 months-79 years. TB lymphadenitis was the most common form (45 cases), followed by soft tissue 14 cases, bone 4, intestine 3, and 2 cases for endometrium, skin, testis and epididymis, and one case for ovary, tonsil, larynx, prostate, parotid gland, synovium, stomach, and kidney. The diagnosis was confirmed by presence of acid-fast bacillus in tissue section by Ziehl Neelsen staining and good response to anti-TB treatment. Conclusion: Although the TB lymphadenitis was the most common type, but in regions with high rate of TB, considering extra pleuro-pulmonary TB in unusual clinical setting is important and using appropriate diagnostic procedures and treatment if it is necessary.
Ar.rafiei (phd), Y.kuade (phd),
Volume 7, Issue 1 (4-2005)

Background&Objective: Both CD4+ type 1 helper (Th1) cells and CD8+ T cells play effective roles in protection against Mycobacterium tuberculosis infection. MPB51, a major mycobacterial secreted protein, induces humeral and cellular immune responses against mycobacterial infection. In addition, DNA vaccine encoding MPB51 can induce cellular immune responses and protective immunity upon challenge with M.tuberculosis. This study address to identify T-cell immunodominant epitopes on MPB51 in BALB/c mice. Materials&Methods: We cloned DNA encoding MPB51 molecule in pCI plasmid. After constructing MPB51 DNA-covered gold cartridge, BABL/c mice were immunized by using a gene gun system. Two weeks after the last immunization, the immune spleen cells were cultured in response to synthetic overlapping library peptides covering the mature MPB51 sequence or medium alone. Intracellular and cell culture supernatant gamma interferon (IFN-) production was analyzed by using flow cytometry and ELISA, respectively. Results: The findings of present study indicate that DNA vaccination can course strong mmune response only against the peptides contain 21-40 aminoacids. Further analysis with a computer – assisted algorithm permitted the identification of nine aminoacids of (P24-32) as immunodominant CD8+ T cell epitope. Conclusion: This study proved than the MHC class I-peptide (H2-Dd-P24-32) complex is recognized by (IFN-)–producing CD8+ T cells. We observed by using T-cell subset depletion that CD8+ T cells are the only P24-32-responded T-cells in BABL/c mice. The data obtained are useful for identifying cellular immune responses against TB and for designing a new vaccine against M.tuberculosis infection.
Semnani Sh, Besharat S, Rafiee S, Keshtkar Aa, Roshandel Gh, Abdolahi N, Jabbari A,
Volume 8, Issue 3 (10-2006)

Background&Objective: 15-20% of TB cases are extra pulmonary tuberculosis (EPTB). Abdominal TB is the most common type of extra intestinal TB. Signs and symptoms of abdominal TB are unspecific. In this study, we identified all GITB cases in Golestan province (Iran) between 1999 and 2003 and determined their demographic characteristics. Materials&Methods: We reviewed all new cases of TB reported during 1999-2003 from TB centers of Golestan province .Then EPTB and especially GI and abdominal TB cases were selected. We completed a questionnaire containing demographic information for each of them. The information entered the computer in SPSS-13 was used to analyze the data. Results: 30 patients had been treated for GI and abdominal TB, most of them were females (22 cases, 73.3%). Mean age of the patients was 32.03±13.73 with higher incidence in age before 40 years old (70%). Most common complaints of the patients were fatigue, weight loss, anorexia, fever and abdominal pain, respectively. In 66.7% of patients the diagnosis was pathologically documented. Conclusion: Our data suggest that 38.46% of all TB cases in Golestan province were EPTB, and this scale is higher than other studies. In this study, 5.27% of EPTB cases were GI and abdominal TB, higher than the world reports (3%).
Hamid Reza Joshaghani, Ezzat Ollah Ghaemi, Farhad Niknejad, Heydar Tavilani,
Volume 9, Issue 4 (1-2008)

Background & Objective: Adenosine deaminase is an enzyme which catalyses adenosine to Inosine. The determination of adenosine deaminase in body fluids is important for the diagnosis of tuberculosis. There are contradictory reports about the diagnostic value of serum adenosine deaminase in pulmonary tuberculosis. This study was set up to investigate the diagnostic value of serum adenosine deaminase and its isoenzymes activities on pulmonary tuberculosis. Materials & Methods: In this descriptive study, blood samples were obtained from 26pulmonary tuberculosis patients (group 1), 17 suspected tuberculosis with negative in both smear and culture tests (group 2), and 67 healthy subjects (group 3). Total ADA and ADA2 determination was carried out by kinetic method and EHNA Inhibitor, respectively. Results: ADA and ADA2 activities are as follow: 19.35±5.04, 13.35±5.34 (group 1) 17.24±6.20, 11.47±3.92 (group 2) and 13.96±4.25, 7.36±2.91(group 3). The mean differences of ADA and ADA2 activity between group 1 and 2 with group 3 was meaningful. The sensitivity and specificity for ADA and ADA2 tests were (26.9%, 94 %) and (50%, 97 %) respectively. The PPV for ADA and ADA2 were 63.6% and 86.7% and the NPV were 76.8% and 83.3%, respectively. Conclusion: This study indicated that the assessment of these enzymes in serum to some extend can be a useful method for differentiation of healthy subjects from respiratory disease, but these tests do not have enough sensitivity to assist in the diagnoses of tuberculosis patients from other respiratory diseases.
Abbas Ali Imani Fooladi (phd), Morteza Sattari (phd), Kiyumars Ghazisaeidi (phd),
Volume 10, Issue 3 (10-2008)

Background and Objective: Tuberculosis is one of the major problem facing of globle health. Drug resistance of mycobacterium tuberculosis to antimicrobial agent has strongly emerged the need for achiving the new drugs. Garlic as medical plants has long been taken under investigation. This study for antibacterial effect was done to determine the morphological alteration of Mycobacterium tuberculosis due to garlic choloformic extract. Garlic extract contains allicine (thio-2-propen-sulfonic acid-s-allil ester) is one of its effective antimicrobacterial substance. Materials and Methods: In a in-vitro study, the standard strain of Mycobacterium tuberculosis H37RV and clinical isolated strain was cultured in the middle broke 7H9 broth with different concentration of garlic extract in different 12, 24, 48, 72 hours. Morphological althertits of mycobacterium inspected with macroscopic and microscopic studies. Results: The garlic exteract caused conversion of rough colonies to smooth and mucoid colonies and in microscopic studies morphologic change of mycobacterium from bacilli form to coccobacilli and cocci was observed. Also 0.67 mg/ml of garlic exteract on 48h period inhibited both of sensitive (standard strain of H37RV) and resistance (clinical strains) Mycobacterium tuberculosis. Conclusion: This study showed that garlic extract in addition to inhibiting growth, change the morphology of Mycobacterium tuberculosis from baccilli to cocoibaccill form and also alter the colony apearance from rough to smooth shap.
Alavi Sm (md), Sefidgaran Gh (bsc), Albaji A (msc), Nezhad Eslami A (md),
Volume 12, Issue 1 (3-2010)

Background and Objective: Previous studies have shown that vitamin D is involved in host immune response toward Mycobacterium tuberculosis (MTB). The aim of this study was to determine if administration of vitamin D can improve treatment outcome and whether is able to increase the rate of sputum clearance of MTB in patients with pulmonary tuberculosis (PTB). Materials and Methods: This randomized clinical trial study was conducted on 96 patients with lung tuberculosis in Ahvaz, Iran during 2008-09. The patients were 18>=years old with sputum positive for acid fast bacillus. Patients were placed in two equal groups as cases and controls. Cases were treated by standard anti TB regimen plus 800 IU/day vit D orally. Controls were treated only by standard anti TB regimen. Follow up sputum examination for presence AFB was performed at the end of month 1, 2, 3, 4 and treatment period. Data were analyzed in SPSS-16 by using descriptive statistics test, chi square and fisher exact test. Results: Mean±SD age of cases and controls was 39.1±17.8 and 38.3±17.6 years, respectively. Overall cure rate in case and control was 93.8% and 95.8% respectively, with no significant difference. The rate of negative sputum of cases in the end of months 1, 2, 3, 4 and treatment period was 66.7%, 78.5%, 93.8% and 93.8% respectively, and for controls was 35.4%, 66.7%, 91.7% and 95.8% respectively. There was significant difference between two groups in the end of first and second month (P<0.05). Conclusion: This study showed that vitamin D as a supplemental drug does not improve the overall treatment outcome among lung TB patients, but it may be able to increase the rate of sputum clearance of Mycobacterium tuberculosis.
Alavi Sm (md), Nadimi M (md), Shokri Sh (md),
Volume 12, Issue 2 (6-2010)

Background and Objective: Diagnosis of latent tuberculosis infection (LTBI) by tuberculin skin test (TST) is accompaind with limitations. A few documented data exist regarding the performance of serology tests for LTBI diagnosis in HIV infection. The aim of this study was to determine LTBI prevalency and compare TST results and IgM antibodies against M.tuberculosis antigens (IAMA) for the diagnosis of LTBI in HIV infected individuals. Materials and Methods: In this discriptive study, sixty two HIV infected subjects were chosen randomly from an addict treatment center in Ahvaz southwest Iran during 2008. The patients underwent TST, using 5 TU of purified protein derivative, and IAMA was measured. Data were analyzed using SPSS-15 software and Chi-Square test. Results: From 62 studied cases, 34 (54.8%) had positive result for TST, whereas 6 (9.7%) had positive IAMA. LTBI was diagnosed in 37 (59.7%) by either TST or IAMA. Overall concordance between TST and IAMA was 45.2%. In subjects with positive test by either TST or IAMA, only 4.8% had positive test by either diagnostic procedure. Discordant results were found in 54.8% of subjects. Positive results for both diagnostic methods in subjects with above and below 200 CD4-cell/mm3 did not show any significant differences. Conclusion: This study showed that LTBI prevalence among HIV infected individuals among addict patients, in this region is higher than other parts of the world. Also TST is a useful test for LTBI diagnosis is preferable to IAMA method.
Alavi Sm (md), Moola K (md),
Volume 12, Issue 3 (9-2010)

Background and Objective: The incidence of infections is one of the most disturbing problems in the management of patients with systemic lupus erythematosus (SLE). The aim of this study was to describe the role of tuberculosis (TB) as a cause of fever in SLE patients. Materials and Methods: In this descriptive study 103 SLE patients enrolled in Ahvaz, South-West of Iran during 2000 - 06. Patients were diagnosed according to American College of Rheumatology criteria (at least 4 of 11 criteria). Diagnosis of tuberculosis was based on Iranian National Program against TB criteria. The infection free patients were given corticosteroid therapy. Results: In this study 20 patients did not follow the complete cycle and finally 83 patients were established as sample population of this study. Mean age of patients was 22.2±10 years, female to male ratio was 9.2:1, mean duration of treatment was12±3.2 months and mean of daily dose of prednisolone was 28.2±13 mg.From total of patients, 8 (9.6%) had active tuberculosis. five patients had pulmonary and three with other type of TB, respectively. One of the above eight patients eventually died due to SLE/TB. Conclusion: Tuberculosis is one of the important causes of fever among patients with SLE under treatment of corticosteroid. In approaching febrile SLE patient TB should always be considered as a treat.
Jahani S (msc), Elahi N (msc), Shahinzade A (msc), Hakim A (msc), Latifi Sm (msc),
Volume 12, Issue 4 (1-2011)

Background and Objective: Although directly observed treatment (DOT) strategy had decreased tuberculosis (TB) mortality, but in developing countries, TB is yet one of the leading cause of deaths. Inappropriate treatment regimens and poorly planned and one of the TB control programs have contributed to rise in its incidence. The purpose of this study was to describe knowledge, attitude and compliance with tuberculosis treatment. Materials and Methods: This sescriptive – analytic study was done on 167 tuberculosis patients in Ahvaz-Iran during 2009. A questionnaire, observation, sputum smear, potts – cozart test (for detect of isoniazide metabolites in urine) was used for data collection. Reability of questionarie was determined by alpha-cronbach correlation method (α=0.81). Data analyzed with Chi-Square test. Results: The findings showed that 52.7%, 35.3% and 12% of the patients demonstrated good, midscores and poor adherence to drug regiment respectively. Also there was a significant relation beween control of medication and knowledge and attitude in tuberculosis patients (P<0.05). Conclusion: This study showed that a half of patients used medication according to DOT strategy, knowledge and attitude were effective on quality of adherence to the medication.
Maleki I, Godazandeh Gh,
Volume 13, Issue 1 (3-2011)

Aspiration pneumonia is a critical disease and can result from a various causes. Epiphrenic diverticula is a rare disorder, which can cause aspiration of food material contained in it. Mediastinal tuberculosis can also cause traction diverticula at mid-esophagus, which usually are asymptomatic and induce no complication. In this article we describe a case, suffering of all these three disorders and after seven years of surgery and medical treatment any symptom was not found in the patient.

Arsang Sh (msc), Kazemnejad A (phd), Amani F (phd),
Volume 13, Issue 3 (9-2011)

Background and Objective: The characterization of any disease have important role for the evaluation and control strategy and programming of diseases. This study was done to determine the epidemiology of Tuberculosis in Iran during 2001-08. Materials and Methods: In this descriptive cross sectional study, Annual percentage change (APC), average annual percentage change (AAPC) of Tuberculosis incidence rate, mortality of Tuberculosis, case detection rate, success percentage in Tuberculosis treatment and relapses cases during 2001-08 have been studied in Iran. Linear segmented regression model was used for analysis trend of Tuberculosis and estimate parameters. Results: The trend of Tuberculosis smear positive (SP) incidence rate was reduced in Iran during 2001-08. Anually, 4.1% and 3.6% reduction took place in incidence rate and relapses cases, respectively. Tuberculosis mortality decreased annually by 6.8% and success in case detection increased by 2.5%. The Tuberculosis treatment though AAPC is decreasing by 0.5%. The trend of Tuberculosis are higher among women and in both sexes over 65 years of age. Conclusion: This study showed that trend of SP pulmonary tuberculosis and treatment success rate is decreased, but case detection was increased.
Alavi Sm (md), Ahmadi F (md), Zargari N (md),
Volume 14, Issue 2 (6-2012)

Background and Objective: Risk factors of tuberculosis vary in communities according to different socioeconomic conditions. Knowing these risk factors help to control the disease. This study was done to determine the main risk factors of pulmonary tuberculosis acquisition in hospitalized patients. Materials and Methods: In this data based, case-control study 173 tuberculosis patients (as cases) and 305 non tuberculosis patients (as controls) hospitalized in Razi hospital in Ahvaz, Iran during 2001-07 were gone under investigation. Risk factors included injecting drug addiction, smoking, HIV infection, diabetes mellitus, imprisonment and corticosteroid usage. Data were analyzed using SPSS-13, Chi-Square and Fisher exact tests. Odds ratio was determined for risk factors. Results: Frequencies of the main risk factors in case and control groups were as: smoking 54.3%, 14.8% (p=0.0001, OR: 6.5), HIV infection 11.5%, 3% (p=0.0002, OR: 4.3), injecting drug addiction 18%, 3.3% (p=0.0001, OR: 6.7), diabetes mellitus 22.5%, 5.9% (p=0.0001, OR: 4.6) and imprisonment 20.2%, 3.9% (p=0.0001, OR: 6.2), respectively. Corticosteroid use and renal failure were similar in cases and controls. Conclusion: This study showed that smoking, HIV infection, injecting drug addiction, diabetes mellitus and imprisonment were the main risk factors for tuberculosis acquisition in this region.
Alavi Sm , Talebi Z, Bakhtiarinia Pp (md),
Volume 14, Issue 3 (9-2012)

Background and Objective: Human immunodeficiency virus (HIV) pandemic is increasing word-wide. Tuberculosis is the main cause of death and low quality of life in HIV infected patients. The prevalence of Tuberculosis in HIV infected patients varies in different areas according to socioeconomic, cultural and geographical situation. This study was done to asses the pulmonary Tuberculosis risk factors in hospitalized HIV positive patients in Ahvaz, Iran. Materials and Methods: In this data based study all medical files of admitted HIV positive patients in Razi hospital in Ahvaz in south west of Iran were reviewed during 2001-09. Demographic characteristics and HIV Tuberculosis related variables were analyzed using SPSS-16, Fisher's exact test and Odds Ratio. Results: Out of 123 HIV cases 99 (80.5%) were injecting drug user (IDU), sixty eight (55.3%) had imprisoment history. Eighty one patients (65.8%) had Tuberculosis, in which 46 had co-morbidities such as infective endocarditis or viral hepatitis, 79 cases were IDU, 61 cases had imprisonment history and 24 cases had CD4 count below 200. There was a significant association between Tuberculosis and IDU, imprisonment and CD4 count (P<0.05). Conclusion: This study showed that the rate of Tuberculosis in HIV positive patients is higher than the rate in previous studies performed in Iran. Also exposure to Tuberculosis cases in prison, IDU and low CD4+ T- lymphocyte count are the main risk factors for Tuberculosis acquisition.
Khodabakhshi (md), Asali A (md), Behnampour N (msc), Abbasi A (md), Adel Barkhordar Ar (md), Hashemi Frad A,
Volume 14, Issue 4 (1-2013)

Background and Objective: Since accurate and quick clinical and paraclinical diagnostic methods are not available, in some cases diagnosis of active pulmonary tuberculosis occurs after considerable time from the onset of disease. This study was designed to determine the diagnostic value of High Resolution Computed Tomographic (HRCT) scan in active pulmonary tuberculosis, in Gorgan, Golestan province, North of Iran. Materials and Methods: This diagnostic screening study was carried out on 135 (79 male and 56 female) hospitalized patients suspected with active pulmonary tuberculosis, and HRCT was used in their course of treatment as recommendation of their clinician. The patients were chosen from 5th Azar hosptial during 2009-10. Also it should be mentioned that patients were selected on avaliabity bases, and they were examined by smear, and sputum culture. The patients with negative smear and culture were set up as true healthy group (64 subjects). The lung or small nuddles in HRCT was considered as proper position of lung involvument in active lung pulmonary. The HRCT findings between the case group (71 subjects) and healthy group were compared. According to HRCT findings, the sensitivity and specifity were determined for each patient. Data were analyzed using SPSS-16 and Chi-Square test. Results: In this study, sensitivity, specificity, positive predictive value and negative predictive value of HRCT in active pulmonary tuberculosis were equal to 97.2%, 71.9%, 79.3% and 95.8% respectively. Involvement of upper and middle lobe of the right lung and upper lobe of the left lung were significantly higher than the control group (P<0.05). Conclusion: This study showed that HRCT has high sensitivity and specificity in diagnosis of active pulmonary tuberculosis and can be used as a quick diagnostic way in active pulmonary tuberculosis, especially in patients with strong clinical suspicion and negative smear.
Adineh Ha, Motametdi B, Veisi M, Bagheri S,
Volume 16, Issue 2 (6-2014)

Background and Objective: Failure of tuberculosis (TB) treatment is a major problem of health systems in developing countries. This study was done to identify the Risk factors of tuberculosis treatment failure in the Sistan and Bulochestan province, the high risk region in South-East of Iran. Methods: This case – control study was carried out on 52 tuberculosis patients (smear -positive and category- I therapy) treated during six months period. Patients with treatment failure were considered as cases and patients with negative smear after 6 months of treatment with anti-tuberculosis (TB) medicines were considered as control group. Demographic, clinical and treatment outcomes were recorded for each patient. The multivariate logistic regression was performed to determine the predictors of treatment failure. Results: Family history of tuberculosis (95% CI: 1-12.56, OR=3.55, P=0.04,), smoking (95% CI:1.58-51.21, OR=9, P=0.01), drug addiction before or during the treatment period (95% CI: 5.28-123.91, OR=25.6, P=0.0001) and low body weight (95% CI:1.05-12.6, OR=3.65, P=0.04) were risk factors for treatment failure. Conclusion: Family history of tuberculosis, weight loss during treatment, smoking and drug addiction, were considered as risk factors for treatment failure in National Tuberculosis Control Programme (NTCP) in south-east of Iran.

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مجله علمی دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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