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Showing 3 results for Zahedi

Morteza Jarrahi (msc), Mahdi Zahedi Khorasani (phd), Masoud Ajorloo (md), Abbas Ali Taheriayn (md),
Volume 11, Issue 1 (Spring 2009)

Background and Objective: Aloe barbadensis Miller plant was used for treatment of wound healing in traditional medicine. However it has different and sometimes contradictory effects. In this study the effect of Aloe barbadensis Miller gel on skin incisional wound healing in Rat was investigated. Materials and Methods: In this experimental study, forty male wistar Rats were randomly divided into 4 experimental groups including: sham operated, control and two treatment groups. Under deep anesthesia, an incision (3cm, full thickness) was made over skin of the back in Rats. The animals of sham group received no treatment. Control group received topical cold cream twice per day (from beginning to end of experiment) and treatment groups' similarliy received topical Aloe barbadensis Miller gel mixed with cold cream (25% and 75%). For computing the percent of wound healing, the area of wound measured at the days 2, 4, 6, 8, 10, 12, 14 and 16 after beginning of experiments. Results: Aloe barbadensis Miller gel at concentration 25% and 75% significantly improved wound healing at 12th day and 8, 10 and 12th days, respectively in comparison with control group. Conclusion: This study indicated that local administration of Aloe barbadensis Miller gel, accelerate the skin incisional wound healing in Rat. This healing is related to the gel concentration.
Momenabadi S , Zahedi Khorasani M , Vakili A,
Volume 17, Issue 3 (Autumn 2015)

Background and Objective: Several studies have shown that inhalation of Lavandula angustifolia L. (Lavender) reduces hypertension, while systemic effects and mechanism of action of lavender oil on blood pressure is not clear. This study was carried out to evaluate the effect of intravenous and ntraperitoneal injection of Lavandula angustifolia L. oil on normal blood pressure in male rats. Methods: In this experimental study, 70 male Wistar rats were randomly allocated into 10 groups (n=7). Following anesthetizing the animals with sodium thiopental, femoral artery and vein were cannulated respectively for recording blood pressure and injection of Lavandula angustifolia L. oil. Lavender oil or its vehicle (Propylene glycol) was injected by intravenous (25, 50 and 100 mg/kg/bw) or intraperitoneal injection (500mg/kg/bw). For the evaluation of the mechanism of Lavender oil, L-NAME (4mg/kg/bw), atropine (1mg/kg/bw), indomethacin (5 mg/kg/bw) or saline was injected intraperitoneally before intravenous administration of Lavender angustifolia L. oil. Results: Intravenous injection of Lavender oil of 25 and 50 mg/kg/bw reduced arterial blood pressure in compare to control group (P<0.05) and dose of 50 mg/kg/bw was more effective than dose of 25 mg/kg/bw (P<0.05). 100 mg/kg/bw of Lavender angustifolia L. oil caused serious fall of blood pressure and resulted in animal death. Intraperitoneally injection of Lavender angustifolia L. oil at dose of 500 mg/kg reduced arterial blood pressure that this reduction was longer than intravenously administration of Lavender oil (P<0.05). Intraperitoneal injection of L-NAME, atropine or indomethacin had no significant effect on baseline of blood pressure and hypotensive effect of Lavender angustifolia L. oil. Conclusion: Intravenous injection of Lavandula angustifolia L. oil in doses of 25 and 50 mg/kg/bw reduced arterial blood pressure in rat, but intraperitoneally injection of Lavender oil at dose of 500 mg/kg/bw prolonged the reduction of blood pressure in animals.
Mahdi Zahedi , Sasan Tabrizi , Alireza Fatemi ,
Volume 23, Issue 4 (Winter 2022)

Background and Objective: Coronary artery disease (CAD) is one of the major cardiovascular diseases that affect the global population. This study was performed to evaluate the electrocardiogram (ECG) changes of patients before and after coronary artery bypass graft (CABG) surgery.
Methods: This descriptive-analytical study was performed on 100 patients (71 males and 29 females) in the age range of 37 to 78 years (mean age of 57.87±8.14 years) by census method undergoing CABG surgery in Amir Al-Momenin Kordkoy Hospital, north of Iran during the second half of 2020. Data including age, sex, and results of ECG changes, including changes in heart rate and pulse rate (PR) the day before surgery, the day of hospitalization, 4 hours after surgery, 18 hours after surgery, one day, and two days after surgery was recorded in a questionnaire.
Results: The highest mean heart rate and PR were observed at 4 hours after surgery and then heart rate and PR were reduced and on the second day, heart rate and PR were lower than  the day of hospitalization (P<0.05).
Conclusion: Considering the significant changes in ECG after surgery, careful examination and monitoring of patients, especially high-risk individuals led to early detection of significant changes in patients and reduced subsequently complications in patients with appropriate and timely treatment.

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مجله علمی دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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