Background and Objective: Cyclooxygenase-2 (COX-2) is a proinflammatory enzyme whose principal product, prostaglandin E2 (PGE2), may contribute to the development of type 2 diabetes. Genetic polymorphisms are among the factors that can influence COX-2 activity or expression. This study aimed to evaluate the association between the COX-2 gene polymorphism (-765G>C) and serum PGE2 levels in patients with type 2 diabetes.
Methods: This case-control study included 50 patients with type 2 diabetes and 50 healthy individuals attending Shahid Sayyad Shirazi Teaching Hospital in Gorgan, Iran. Serum FBS, HbA1c, and PGE2 levels were measured using ELISA kits, and the gene polymorphism was determined by ARMS-PCR.
Results: The COX-2 -765G>C polymorphism was not significantly associated with either diabetes or PGE2. PGE2 levels were higher in patients with diabetes (43.42±31.2) than in healthy controls (17.67±6.38; P<0.05). PGE2 levels were significantly higher in individuals with the CG genotype (41.15±30.99) than in those with other genotypes (P<0.05).
Conclusion: The COX-2 -765G>C polymorphism, as an inflammatory mediator-related variant, had no effect on the risk of diabetes or its complications.