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:: Volume 21, Issue 1 (3-2019) ::
J Gorgan Univ Med Sci 2019, 21(1): 23-30 Back to browse issues page
Effect of atorvastatin on spatial memory in high-fat dietary rats
Mohammad Nosrati1 , Hamid Sepehri 2
1- General medical student, Student Research Committee, Neuroscience Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Associate Professor, Neuroscience Research Center, Department of Physiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran , hamsep49@yahoo.com
Abstract:   (8330 Views)
Background and Objective: Atorvastatin is a member of the statin family with lipophilic character and anti-hyperlipidemic effect. There is many evidence that atorvastatin has protective effect on cognitive function. This study was done to evaluate the effect of atorvastatin on spatial memory in rats following a high-fat diet.
Methods: This experimental study was performed on 35 male Wistar male rats. Animals were randomly allocated into 5 groups including control, control plus atorvastatin and sham (received high-fat diet for 4 weeks) and high-fat diet plus atorvastatin (10 and 50 mg/kg, for 4 weeks). Learning and spatial memory were measured using Morris water maze for a 6-day period including 5 days training and the last day, test day (probe day).
Results: High-fat diet reduced learning and poor memory performance during training and probe compared to the control group, and also on the probe day, the high-fat group spent less time in the target quarter (P<0.05). Administration of atorvastatin after a high-fat diet improvement spatial memory in compared to high-fat group (P<0.05).
Conclusion: Short-term treatment (4 weeks) with atorvastatin in high-fat dietary rats can improve spatial memory.
Keywords: Atorvastatin, Spatial memory, Morris Water Maze, High-fat diet, Rat
Full-Text [PDF 337 kb]   (14727 Downloads)    
Type of Study: Original Articles | Subject: Physiology - Pharmacology
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Nosrati M, Sepehri H. Effect of atorvastatin on spatial memory in high-fat dietary rats. J Gorgan Univ Med Sci 2019; 21 (1) :23-30
URL: http://goums.ac.ir/journal/article-1-3292-en.html


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Volume 21, Issue 1 (3-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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