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:: Volume 18, Issue 2 (6-2016) ::
J Gorgan Univ Med Sci 2016, 18(2): 35-40 Back to browse issues page
Effect of chronic stress and intra-amygdal memantine administration on alterations of brain’s volume and weight to volume and weight ratio of the adrenal gland in male mice
Sadeghi B1 , Zardooz H2 , Sahraei H3 , Sarahian N 4
1- M.Sc in Physiology, Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran
2- Assistant Professor, Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Professor, Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran
4- M.Sc in Physiology, Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran , sarahiannahid@yahoo.com
Abstract:   (8056 Views)

Background and Objective: After chronic stress, brain volume and weight reduces and in turn, adrenal weight and volume increases. This study was performed to determine the effect of chronic stress and memantine administration within amygdala on the alterations of brain’s volume and weight ratio to volume and weight of the adrenal gland on male mice.

Methods: In this experimental study, bi- or unilateral amygdala cannulation was preformed stereotaxically. A week after recovery, animals were received different doses of memantine (1, 0.5, and 0.1 µg/mouse), five min before stress induction. Electric foot shock induced to animals for seven consecutive days. At the end of the seventh day, animals were sacrificed and their brain and adrenal glands were fixed in formalin 4%. The volume and weight was determined by mercury immersion and accurate balance respectively.

Results: Stress non- significantly reduced brain’s volume ratio to volume of the adrenal gland and brain’s weight ratio to weight of the adrenal gland. Memantine administration within amygdala inhibited stress effect. Memantine administration in low and medium doses within right and left amygdala significantly increased brain’s volume and weight ratio to volume and weight of the adrenal gland (P<0.05).

Conclusion: Memantine dose and side dependently inhibits the effect of induced stress in male mice. Also, unilateral memantine administration within the left and right amygdala was more effective.

Keywords: Adrenal Gland, Brain, Amygdala, Memantine, Volume, Weight
Full-Text [PDF 263 kb] [English Abstract]   (10625 Downloads) |   |   Abstract (HTML)  (520 Views)  
Type of Study: Original Articles | Subject: Neurosciences
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Sadeghi B, Zardooz H, Sahraei H, Sarahian N. Effect of chronic stress and intra-amygdal memantine administration on alterations of brain’s volume and weight to volume and weight ratio of the adrenal gland in male mice. J Gorgan Univ Med Sci 2016; 18 (2) :35-40
URL: http://goums.ac.ir/journal/article-1-2759-en.html


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Volume 18, Issue 2 (6-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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