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Effect of exercise program and Curcumin supplementation on serum level of immunoglobulin A in rats exposed to lead Acetate
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Mirdar Sh   1, Ramezannezhad AA2 , Arzani A2 , Alinezhad M2 , Hajizade A3 |
1- Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran , s-mirdar@umz.ac.ir
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
3- Assistant Professor, Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran |
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Abstract: (11929 Views) |
| Background and Objective: Lead as an environmental pollutant can damage the immune system. This study was done to determine the effect of moderate-intensity exercise and Curcumin supplement on serum level of immunoglobulin A in rats exposed to lead acetate. Methods: In this experimental study, 46 male rats were allocated into six groups including Control (C), vehicle (V), lead (L), lead and exercise (LE), lead and curcumin (LC), Lead+exercise+curcumin (LEC). Animals in training groups ran on treadmill for 8 weeks (25- 64 minutes per daily, 15-22 meter/minute and 0% grade). Animals in Lead, LE, LC and LEC groups were received lead acetate (20 mg/kg/bw) and vehicle animals were received ethyl oleat (30 mg/kg/bw) Intraperitoneally for 3 days per week for 8 weeks. Rats in curcumin and LEC groups were received Curcumin (30mg/kg/bw), for 3 day per week for 8 weeks. IgA level were measured by single radial immuno diffusion method. Results: Lead acetate significantly increased MDA levels at P<0.05 in animals. IgA level was 0.2, 0.41 and 0.47 mg/dL in Lead, LE and LEC groups (P<0.05). Conclusion: The simultaneous use of endurance exercise training and curcumin due to increased IgA activity has beneficial effects against lead poisoning. |
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| Keywords: Lead acetate, Immunoglobulin A, Endurance training, Curcumin |
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Full-Text [PDF 261 kb]
[English Abstract]
(13674 Downloads)
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Type of Study: Original Articles |
Subject:
Physiology - Pharmacology
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