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Effect of resistance exercise on protein content and mRNA expression of NT 4/5 in rat slow and fast muscles
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Eslami R1   , Gharakhanlou R 2, Mowla J3 , Rajabi H4 , Mohammadkhani R5 |
1- Assistant Professor, Faculty of Physical Education, Allameh Tabatabai University, Tehran, Iran
2- Associate Professor, Department of Physical Education, Faculty of Humanity, Tarbiat Modares University, Tehran, Iran , ghara_re@modares.ac.ir
3- Associate Professor, Department of Genetics, Faculty of Science, Tarbiat Modares University, Tehran, Iran
4- Associate Professor, Department of Physiology, Faculty of Physical Education, Kharazmi University, Tehran, Iran
5- MSc in Exercise Physiology, Department of Physical Education, Humanity Faculty, Tarbiat Modares University, Tehran, Iran |
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Abstract: (9827 Views) |
| Background and Objective: Trophic factor family plays a key role for neuromuscular system healthy. This study was carried out to determine the effect of one session of resistance exercise on protein content and mRNA expression of NT4/5 in rat slow and fast muscles. Methods: In this experimental study, sixteen adult male rats randomly were allocated into resistance exercise (T) and control groups. The resistance training protocol consisted of climbing a 1-meter–long ladder, with a weight attached to a tail sleeve. Quantitative Real time RT-PCR for NT-4/5 expression and ELISA Kit for protein assay were used. Results: Resistance training significantly decreased mRNA expression and increased protein of NT4/5 in soleus muscle (P<0.05). Significant alteration was not detected in flexor hallucis longus muscle. Conclusion: One session of resistance training can alter protein and mRNA of NT-4/5 in skeletal muscle and this alteration was dependent on muscle type. |
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| Keywords: Resistance Training, Neurotrophin-4/5, Protein, Muscle |
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Full-Text [PDF 295 kb]
[English Abstract]
(11377 Downloads)
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Type of Study: Original Articles |
Subject:
Physiology
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