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Concordance of Empirical Antibiotic Therapy with Definitive Prescriptions and Antibiogram Results
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Roghieh Golsha1    , Hesamaddin Shirzad-Aski2 , Erfan Rezaieshirazi3 , Helia Borujerdi Karimi4 , Samira Eshghinia *5 |
1- Professor of Infectious Diseases Research Center, Jorjani Clinical Sciences Research Institute, Golestan University of Medical Sciences, Gorgan, Iran.
2- Assistant Professor of Infectious Diseases Research Center, Jorjani Clinical Sciences Research Institute, Golestan University of Medical Sciences, Gorgan, Iran.
3- Genral Physician, Infectious Diseases Research Center, Jorjani Clinical Sciences Research Institute, Golestan University of Medical Sciences, Gorgan, Iran.
4- Medical Student, Infectious Diseases Research Center, Jorjani Clinical sciences Research Institute, Golestan University of Medical Sciences, Gorgan, Iran.
5- Associate Professor of Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran. Ischemic Disorders Research Center, Jorjani Clinical Sciences Research Institute, Golestan University of Medical Sciences, Gorgan, Iran. , dreshghinia@yahoo.com |
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Abstract: (5051 Views) |
Background and Objective: Early antibiotic administration is a cornerstone of infection control and treatment. Empirical treatment based on clinical signs and available guidelines reduces mortality and accelerates recovery; however, a lack of information about bacterial species and antibiotic susceptibility may lead to unfavorable outcomes. This study aimed to assess the concordance of empirical antibiotic therapy with definitive prescriptions and antibiogram results.
Methods: This descriptive study included 152 hospitalized patients receiving antibiotics (80 men and 72 women; mean age, 54.41±20.91 years), enrolled by census sampling from the infectious diseases and surgical wards of Shahid Sayyad Shirazi Teaching Hospital in Gorgan, Iran during 2021. Demographic characteristics and data on the initial diagnosis, empirical antibiotic type, microbial culture and antibiogram results, definitive treatment, and treatment duration were extracted from patient records and evaluated.
Results: The most common clinical manifestations were fever (77%) and weakness and fatigue (39%), while the leading reasons for hospitalization were sepsis (31.58%) and urinary tract infection (25.66%). Blood (45.39%) and urine (32.24%) were the most frequently cultured clinical specimens. Escherichia coli (38.8%) and Staphylococcus epidermidis (23.7%) were the most commonly isolated bacteria. Empirical antibiotics were prescribed on 454 occasions, but antibiograms were performed in only one-quarter of cases. The commonly used antibiotics for which antibiograms were performed included ciprofloxacin (14.5%), clindamycin (42%), and ceftriaxone (66.2%). Amikacin (68.4%), ceftriaxone (64.5%), and gentamicin (56.6%) were the antibiotics most frequently included in antibiogram testing. Empirical and definitive therapy were concordant in 75% of cases. The most frequently prescribed antibiotics in definitive therapy were ciprofloxacin (14.04%), clindamycin (13.2%), and ceftriaxone (12.9%). The highest concordance rates in definitive therapy were observed for doxycycline (90%), Tavanex (89.4%), and ciprofloxacin (87.3%), whereas gentamicin (83.3%) and ceftriaxone (40.2%) showed the highest discordance rates.
Conclusion: Empirical antibiotic prescriptions were concordant with definitive prescriptions in most patients. Nevertheless, the antibiotics included in antibiogram testing were not fully aligned with those prescribed in clinical practice. |
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Keywords: Infections [MeSH], Bacteria [MeSH], Microbial Sensitivity Tests [MeSH], Sepsis [MeSH], Urinary Tract Infections [MeSH]
Article ID: Vol28-19 |
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Full-Text [PDF 998 kb]
(1065 Downloads)
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Type of Study: Original Articles |
Subject:
Infectious Medicine
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Golsha R, Shirzad-Aski H, Rezaieshirazi E, Borujerdi Karimi H, Eshghinia S. Concordance of Empirical Antibiotic Therapy with Definitive Prescriptions and Antibiogram Results. J Gorgan Univ Med Sci 2026; 28 (2) :80-88 URL: http://goums.ac.ir/journal/article-1-4682-en.html
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