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:: Volume 16, Issue 1 (3-2014) ::
J Gorgan Univ Med Sci 2014, 16(1): 55-61 Back to browse issues page
Biomechanical evaluation of root extracts of Onosma dichroanthum Boiss. on skin wound healing in rat
Amirkhani Z1 , Norouzian M *2 , Piryaei A3 , Ayatollahi SA4 , Saremi S5 , Dadpay M6
1- MSc in Anatomy, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Associate Professor, Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran , norozian398@yahoo.com
3- Assistant Professor, Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Professor, Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- BSc in Biology, Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- General Physician, Department of Pathology, AJA University of Medical Sciences, Tehran, Iran
Abstract:   (17445 Views)
Background and Objective: Onosma dichroanthum Boiss. is one of the most important mountainous medicinal plants in Iran. This study was done to determine the biomechanical evaluation of root extract ointment of Onosma dichroanthum Boiss. on wound healing in rats. Materials and Methods: In this experimental study, 18 male adult Wistar rats were randomly allocated into control (I), vehicle (II) and treated group with ointment containing of extract 1% of root of Onosma dichroanthum Boiss., (III). 20 mm vertical skin incision wound were made on rats back side. The assessment of the wound healing was carried out at day 14. At the end of study, rats were sacrificed, skin sample were extracted and evaluated by biomechanical method (maximum force, elastic stiffness, energy absorption). Results: There was no significant difference in biomechanical parameters among the treated, vehicle and control groups. Conclusion: Topical application of Onosma dichroanthum Boiss. root have no effect on healing of skin wound in animal model.
Keywords: Onosma dichroanthum Boiss., Wound healing, Biomechanical method, Rat
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Type of Study: Original Articles | Subject: Pharmacology
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Amirkhani Z, Norouzian M, Piryaei A, Ayatollahi SA, Saremi S, Dadpay M. Biomechanical evaluation of root extracts of Onosma dichroanthum Boiss. on skin wound healing in rat. J Gorgan Univ Med Sci 2014; 16 (1) :55-61
URL: http://goums.ac.ir/journal/article-1-1974-en.html
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Volume 16, Issue 1 (3-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)