Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1394
10
1
gregorian
2016
1
1
10
1
online
1
fulltext
fa
Comparison of the Antimicrobial Effects of Silver Nanoparticles Alone and In Combination with Zataria Multiflora Extract On Some Gram-Positive and Gram-Negative Bacteria
تحقيقي
Original Paper
<div>
<p><strong>Abstract</strong></p>
<p><strong> Background and Objective: </strong>The spread of drug resistance in bacteria have prompted researchers to seek suitable alternative for antimicrobial drugs among various medicinal plants and nanoparticles. The aim of this study was to evaluate the effect of silver nanoparticles alone and in combination with methanol extract of <em>Zataria multiflora</em> on five Gram-positive and Gram-negative bacteria.</p>
<p><strong> Methods</strong>: Different concentrations of the nanoparticles and extract alone or in combination with each other were tested against the bacteria, using well diffusion method. Three concentration levels (lowest, average and highest) were prepared form the nanoparticles and the extract for the combination, and finally nine different combinations were prepared.</p>
<p><strong> Results</strong>: The extract and nanoparticles showed inhibitory effects against all the tested bacteria. The maximum diameter of growth inhibition zone in the presence of the extract and nanoparticles were observed in <em>Streptococcus pyogenes</em> (35.6mm) and methicillin-resistant <em>Staphylococcus aureus</em> (20.6mm), respectively. The maximum diameter of growth inhibition zone for the combination was measured in <em>S. pyogenes</em> (31mm).</p>
<p><strong> Conclusion</strong>: The combination of low concentrations of the plant extract and nanoparticles are more effective against bacteria, but the combination of their high concentrations reduce the antibacterial effects in some cases.</p>
<p><strong> </strong></p>
</div>
<p></p>
Silver Nanoparticles, Zataria Multiflora, Antibacterial Effect, Gram-Positive Bacteria, Gram-Negative Bacteria.
24
30
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-380&slc_lang=fa&sid=1
Shirin
Sheikholeslami
100319475328460011098
100319475328460011098
Yes
Young Researchers and Elite Club
Seyed Mahdi
Rezayat
100319475328460011099
100319475328460011099
No
Department of Toxicology & Pharmacology
Reza
Hosseini Doust
100319475328460011100
100319475328460011100
No
Department of Microbiology
Hamid Reza
Ahmadi Ashtiani
100319475328460011101
100319475328460011101
No
Department of Toxicology & Pharmacology