Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1393
10
1
gregorian
2015
1
1
8
4
online
1
fulltext
fa
الگوی مقاومت پنومونی پنوموکوکی نسبت به سفتریاکسون، آزیترومایسین و کوآموکسیکلاو در بالین و آزمایشگاه
Resistance Pattern of Enterococci Isolated from Nosocomial Infections in the Hospitals Located in Gonbad and Gorgan Cities, Iran
تحقيقي
Original Paper
<p>Abstract Background and Objective: Streptococcus pneumoniae is the most common cause of acquired bacterial infections in the respiratory system. In recent years, a high incidence of pneumococcal resistance to different antibiotics has also been appeared. This study was conducted to evaluate the in vivo and in vitro resistance of pneumococcal pneumonia to ceftriaxone, azithromycin and co-amoxiclave in clinical setting and laboratory. Material and Methods: In this single-blind clinical trial study, the participants were the patients with the diagnosis of pneumonia referred to infectious diseases clinic in Vali-e-Asr hospital of Birjand university of Medical Sciences, October 2012 - April 2014. The patients were randomly allocated to one of the three therapeutic regimes including azithromycin, ceftriaxone, and co-amoxiclave. After 48-72 hours that the infection was confirmed by paraclinical findings, the patients with pneumococcal pneumonia remained in the study and their in vivo and in vitro resistance to the above mentioned antibiotics were compared. Results: The most in vitro drug resistance was to co-amoxiclave (41.5%) and the least to ceftriaxone (20.8%) (P>0.05). For In vivo, the most resistance was to azithromycin (47.4%) and the least one to ceftriaxone (6.7%) (p<0.05). The agreement coefficient between the laboratory antibiogram test and the clinical responses to therapeutic regimes of azithromycin, co-amoxiclave and ceftriaxone was 0.25 (p=0.26), 0.46 (p=0.02) and 0.44 (p=0.04), respectively. Conclusion: With regard to the demographic characteristics of the patients in this study, the resistance of Streptococcus pneumoniae to ceftriaxone is less than that of co-amoxiclave and azithromycin in both clinical setting and laboratory. Keywords: Drug Resistance, Streptococcus Pneumonia, Azithromycin, Ceftriaxone, Co-Amoxiclave</p>
Drug Resistance, Streptococcus Pneumonia, Azithromycin, Ceftriaxone, Co-Amoxiclave
66
74
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-259&slc_lang=fa&sid=1
Ebrahim Zade, A
آزاده ابراهیم زاده
100319475328460010940
100319475328460010940
No
School of Paramedicine, Birjand University of Medical Sciences, Birjand, Iran
دانشگاه علوم پزشکی بیرجند
Zare Bidaki, M
مجید زارع بیدکی
m.zare@live.co.uk
100319475328460010941
100319475328460010941
Yes
School of Paramedicine, Birjand University of Medical Sciences, Birjand, Iran
دانشگاه علوم پزشکی بیرجند
Saber Hosseini, SN
سیده نعیمه صابرحسینی
100319475328460010942
100319475328460010942
No
Birjand University of Medical Sciences, Birjand, Iran
دانشگاه علوم پزشکی بیرجند
Gh
shariatzadeh
غلامرضا شریف زاده
100319475328460010943
100319475328460010943
No
مرکزتحقیقات عوامل موثر بر سلامت، دانشکده پزشکی، دانشگاه علوم پزشکی بیرجند، ایران
Derayati, Z
زهره درایتی
100319475328460010944
100319475328460010944
No
Birjand University of Medical Sciences, Birjand, Iran
دانشگاه علوم پزشکی بیرجند