Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1397
10
1
gregorian
2019
1
1
13
1
online
1
fulltext
fa
Evaluation of Bcl-2 and Bax Expression in the Heart of Diabetic Rats after Four Weeks of High Intensity Interval Training
ژنتیک انسانی
Human Genetics
تحقيقي
Original Paper
<div><strong>ABSTRACT</strong><br>
<strong> Background and Objectives: </strong>Diabetes is one of the most common diseases and a major risk factor for cardiovascular disease. Studies have shown that regular exercise can affect apoptosis in cardiomyocytes. The purpose of this study was to investigate the effect of high-intensity interval training on the expression of Bcl-2 and Bax as important apoptosis factors in diabetic rats.<span dir="RTL"></span><br>
<strong>Methods</strong>: After inducing diabetes in 20 male Wistar rats (weighing 250 ± 1.15 g), the rats were randomly divided into a control group and a training group. The training group performed high-intensity interval training five days a week for four weeks, and the control group did not perform any training. After the intervention, RNA was extracted and TCF mRNA was subjected to real time RT-PCR for measuring Bax and Bcl-2 expression in the heart tissue of diabetic rats. Data were analyzed by IBM SPSS Statistics V22 using independent t-test. P-values less than 0.05 were considered as statistically significant.<br>
<strong>Results</strong>: The expression of Bcl-2 increased significantly and the expression of Bax decreased significantly after the four-week training intervention.<br>
<strong>Conclusion:</strong> The high-intensity interval training can have beneficial effects on the expression of apoptotic genes in rats with type 2 diabetes.<br>
<strong>Keywords:</strong> Bax, Bcl-2, High intensity interval training, Heart, Type 2 diabetes.</div>
Bax, Bcl-2, High intensity interval training, Heart, Type 2 diabetes.
15
20
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-555&slc_lang=fa&sid=1
Nasrin
Ramezani
100319475328460014962
100319475328460014962
Yes
Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Tehran University, Tehran, Iran
Behnaz
Vanaky
Bv73ir@yahoo.com
100319475328460014963
100319475328460014963
No
Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
Nader
Shakeri
100319475328460014964
100319475328460014964
No
Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
Zahra
Soltanian
100319475328460014965
100319475328460014965
No
Department of Sport Physiology, Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
Fatemeh
Fakhari Rad
100319475328460014966
100319475328460014966
No
Department of Sport Physiology, Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
Zahra
Shams
100319475328460014967
100319475328460014967
No
Department of Sport Physiology, Faculty of Physical Education and Sports science, Central Tehran Branch, Islamic Azad University, Tehran, Iran