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Showing 4 results for Royani

Z Rahmani, S Royani, Ar Ahmadi,
Volume 7, Issue 1 (spring[PERSIAN] 2013)

Abstract Background and Objective: Every organization requires ongoing evaluation of existing conditions. The purpose of this study is to assess and analyze the standards and criteria that each Laboratory system is required to observe and upgrade them, to determine the gap between the ideal and the current status and finally to present the strategy and executive plan in order to achieve the desirable status. Material and Methods: This study was performed in a medical diagnostic laboratory in Gorgan by using the quality system checklist related to medical diagnostic laboratories, which was revised in 2009. Internal evaluation matrix (Internal Factor Evaluation) was used to examine the main factors in the context of establishing a quality management system in a clinical laboratory.After examining the factors, determining the laboratory status, recording the results of monitoring (in terms of strengths and weaknesses) and determining the gap between existing and desirable status, we provided the appropriate and effective solutions in line with defined standard. Results: of 164 items thatshould have been done in the first assessment, 111 (67.7%) items are in performed group and 53 (32.3%) are not in. After compiling and running a plan, 147 (89.6%) are performed, 15 (9.2%) needed to be modified and 2 (1.2%) still not performed. It is evident that a significant difference (p< 0.05) and a tangible improvement in current problems are seen after establishing the qualitysystem in the laboratory. The lab equipment, lab space and facilities, pre-examination process, testing process and post-examination process are considered .Regarding the health and safety in the laboratory, lab equipment, lab space and facilities, pre-examination process, testing process and post-examination process, no significant difference is observed between before and after the implementation of the program. Conclusion:after establishing the quality system in laboratory, a significant difference and tangible improvement in the current problems are observed. It is implied the importance of pre-planned responses to problems and the performance of strategic planning. Keywords: Strategic Planning, Medical Diagnostic Laboratory, Quality Control
S Royani, S Alijanpor, Z Shirbaghaei, R Khorasaninejad, Gh Roshandel, Aa Ayatollahi, Hr Joshaghani,
Volume 7, Issue 3 (Autumn 2013)

Abstract Background and Objective: Of the most common hypochromic microcytic anemia are iron deficiency anemia and minor thalassemia, which are common in Iran and their differential diagnosis is extremely important. The level of 25-hydroxy vitamin D is the indication of vitamin D blood status. The aim of this study was to compare serum levels of vitamin D in people with minor thalassemia and iron deficiency anemia with healthy subjects in order to investigate the relationship between vitamin D deficiency and iron absorption. Material and Methods: In this case-control study, 24 patients with minor thalassemia, 20 patients with iron deficiency anemia and 24 healthy individuals participated. Groups were matched for age and sex. Testing of Vitamin D level by ELISA, ferritin by quantitative luminescence method and HbA2 by column chromatography was carried out. Results: The number of individuals with low level of vitamin D in iron deficiency group is 15 (75%), in minor thalassemia group is 8 (33/3%) and in the control group 11 (45.8%). Conclusion: In this study, the highest percentage of vitamin D deficiency is observed in cases with iron deficiency anemia. Because of association between vitamin D and anemia, iron and vitamin D supplementation is recommended to enrich the diet. Keywords: Anemia Minor Thalassemia Iron Deficiency Anemia Vitamin D
Royani, S, Ravaghi, H, Ahmadi, Ar, Vafaeian, Z. ,
Volume 9, Issue 3 (Jul,Aug2015[PERSIAN] 2015)


Background and Objective: One of the organizations that have proceeded for very high standard quality management programs, ISO 9001-2008, is medical diagnostic laboratories. One of the important goals of most laboratories in the implementation of this standard is to reduce the current costs of repeated tests.

Material and Methods: The number of repeated tests was evaluated in biochemistry section (Glucose, Urea, Creatinine, Cholesterol, Triglycerides, AST and ALT) and hormones (T3, T4, and TSH) in three stages (pre-standard implementation, three and nine months after performing program).  We analyze the data by Stat data software (version 8) using Pearson chi square test.

Results: The percentages of repeated tests for glucose, urea, creatinine, cholesterol, triglycerides, AST, ALT, T3, T4, TSH were 16.5, 2.57, 2.88, 12.7, 14.9, 10.38, 12.6, 3.55, 4.69, 1.85 for the first time  and 20.5, 5.56, 5.41, 7.25, 20.0, 27.2, 30.1, 0.3, 6.04, 3.08 for the second time and 8, 8.3, 9.2, 7.1, 12.8, 17.4, 19.5, 0.0, 5.81,1.01 for the third time, respectively. The changes in statistical analysis of urea, creatinine, cholesterol, AST, ALT, and TSH were significant. The percentage trend of repeated tests for urea and creatinine was increased while for TSH, it was decreased.

Conclusion: Due to the nature of the experiments and the principles governing repeated tests, the acceptance and implementation of the ISO 9001-2008 only to reduce costs by reducing the percentage of repeated tests cannot be  justified. To implement this process, all aspects of the effectiveness should be considered together.

Keywords: ISO 9001-2008, Medical Diagnostic Laboratory, Effectiveness, Cost Reduction.

Hamidreza Yazdi, Fatemeh Piran , Sanaz Royani, Mojgan Nejabat, Gholamreza Roshandel, Mahsa Taherizadeh, Hamid Reza Joshaghani,
Volume 9, Issue 4 (sep,Oct 2015 2015)


         Background and Objectives: Concentration low-density lipoprotein (LDL) is one of the strongest indicators of atherosclerosis and predicts the diagnosis of cardiovascular diseases. LDL measurement accuracy is very important. LDL can be measured directly, such as enzymatic and nephelometry methods or can be calculated using Friedewald's formula. Despite the development of enzymatic methods and LDL nephelometry still in most laboratories is calculated using Friedewald's formula. The aim of this study was an investigation of correlation coefficient between two methods of measuring LDL- cholesterol levels.

         Methods: This descriptive cross-sectional study, performed on the 1141 patients. Cholesterol, triglycerides, HDL, LDL all patients assayed by enzymatic method. For patients with triglyceride levels of less than 400 mg/dl had LDL levels were calculated by Friedewald's formula. Normal levels of LDL/HDL ratio of less than 3.5 were considered.

          Results: Of the 1141 patients participating in this study, 38.3 % men and 61.7 % women. The mean patient age was 46.3 ± 16.1 years. Mean serum cholesterol, triglycerides and HDL were 177.9 ± 41.1, 132.9 ± 73.2 and 45.8 ± 13.2 mg/dl, respectively. Average direct and calculated LDL concentration was 82.1 ± 23.1 and 105.5 ± 35.8, respectively. The direct measurement of LDL, LDL/HDL levels in 97.1% of cases was normal, while 85.1 % of the calculation of LDL were normal. Pearson correlation coefficients were obtained by two methods: 0.869 (p <0.001).

         Conclusion: Despite the favorable correlation between two methods of measurements of LDL, the results of a calculation method is more than direct method. This can have a negative impact on the judgment of the treating physician.

           Key words: LDL, Enzymatic Method, Friedewald's Formula.

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